{"id":"nifuratel","rwe":[{"pmid":"41586307","year":"2025","title":"Drug repurposing of Nifuratel against methicillin-resistant Staphylococcus aureus through proton motive force disruption.","finding":"","journal":"Frontiers in cellular and infection microbiology","studyType":"Clinical Study"},{"pmid":"40400645","year":"2025","title":"Cutaneous Granuloma Resulting from Mixed Infection with Mycobacterium marinum and Candida metapsilosis: A Case Report of Successful Treatment.","finding":"","journal":"Clinical, cosmetic and investigational dermatology","studyType":"Clinical Study"},{"pmid":"39837228","year":"2025","title":"Nitrogen-doped carbon quantum dots from pumpkin for the sensing of nifuratel and temperature.","finding":"","journal":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","studyType":"Clinical Study"},{"pmid":"39458909","year":"2024","title":"Nifuratel Induces Triple-Negative Breast Cancer Cell G2/M Phase Block and Apoptosis by Regulating GADD45A.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"38488848","year":"2024","title":"Selective Anticervical Cancer Injectable and Self-Healable Hydrogel Platforms Constructed of Drug-Loaded Cross-Linkable Unimolecular Micelles in a Single and Combination Therapy.","finding":"","journal":"ACS applied materials & interfaces","studyType":"Clinical Study"}],"tags":[{"label":"nifuratel","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"G01AX05","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antifungal Agents","category":"pharmacology"},{"label":"Antiparasitic Agents","category":"pharmacology"},{"label":"Antiprotozoal Agents","category":"pharmacology"},{"label":"Antitrichomonal Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"metilmercadon","offLabel":[],"synonyms":["metilmercadon","nifuratel","methylmercadone"],"timeline":[],"approvals":[],"brandName":"Metilmercadon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"nifuratel","explanation":"Imagine your body is a city, and microorganisms are like unwanted visitors. Nifuratel helps keep them from multiplying and taking over by blocking their ability to grow and divide. This helps your body's natural defenses to keep you healthy.","oneSentence":"Nifuratel works by inhibiting the growth of microorganisms.","technicalDetail":"Nifuratel exerts its antimicrobial effects through a mechanism that is not fully understood, but it is thought to interfere with the synthesis of essential biomolecules in microorganisms, ultimately leading to their death or inhibition of growth."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1926","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NIFURATEL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:57:44.848022","biosimilars":[],"competitors":[{"drugName":"inosine","drugSlug":"inosine","fdaApproval":"","relationship":"same-class"},{"drugName":"furazolidone","drugSlug":"furazolidone","fdaApproval":"1958-01-20","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"povidone-iodine","drugSlug":"povidone-iodine","fdaApproval":"1985-11-29","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"ciclopirox","drugSlug":"ciclopirox","fdaApproval":"1982-12-30","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"nifuratel","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"inosine","brandName":"inosine","genericName":"inosine","approvalYear":"","relationship":"same-class"},{"drugId":"furazolidone","brandName":"furazolidone","genericName":"furazolidone","approvalYear":"1958","relationship":"same-class"},{"drugId":"povidone-iodine","brandName":"povidone-iodine","genericName":"povidone-iodine","approvalYear":"1985","relationship":"same-class"},{"drugId":"ciclopirox","brandName":"ciclopirox","genericName":"ciclopirox","approvalYear":"1982","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000167137","NDDF":"005304","UNII":"U60U6P08SP","CHEBI":"CHEBI:135180","INN_ID":"2314","RXNORM":"7419","UMLSCUI":"C0028070","ChEMBL_ID":"CHEMBL514315","KEGG_DRUG":"D01050","DRUGBANK_ID":"DB13724","PUBCHEM_CID":"6433427","SNOMEDCT_US":"703418002","IUPHAR_LIGAND_ID":"12348","MESH_DESCRIPTOR_UI":"D009545"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":94,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G01AX05","allCodes":["G01AX05"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"41586307","title":"Drug repurposing of Nifuratel against methicillin-resistant Staphylococcus aureus through proton motive force disruption.","journal":"Frontiers in cellular and infection microbiology"},{"date":"2025","pmid":"40400645","title":"Cutaneous Granuloma Resulting from Mixed Infection with Mycobacterium marinum and Candida metapsilosis: A Case Report of Successful Treatment.","journal":"Clinical, cosmetic and investigational dermatology"},{"date":"2025 Apr 5","pmid":"39837228","title":"Nitrogen-doped carbon quantum dots from pumpkin for the sensing of nifuratel and temperature.","journal":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy"},{"date":"2024 Sep 26","pmid":"39458909","title":"Nifuratel Induces Triple-Negative Breast Cancer Cell G2/M Phase Block and Apoptosis by Regulating GADD45A.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2024 Mar 27","pmid":"38488848","title":"Selective Anticervical Cancer Injectable and Self-Healable Hydrogel Platforms Constructed of Drug-Loaded Cross-Linkable Unimolecular Micelles in a Single and Combination Therapy.","journal":"ACS applied materials & interfaces"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metilmercadon is a small molecule with synonyms including INIMUR, MACMIROR, MAGMILOR, METHYLMERCADONE, NF-113, and NIFURATEL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}