{"id":"niflumic-acid","rwe":[{"pmid":"41763020","year":"2026","title":"Dual-functional near-infrared fluorescent probe for H(2)S detection and precise COX-2-positive cancer imaging.","finding":"","journal":"Bioorganic chemistry","studyType":"Clinical Study"},{"pmid":"41656545","year":"2026","title":"Harnessing Hybrid Chemistry: Novel Ethyl Ferulate Ester of Niflumic Acid for Enhanced Therapeutic Benefits.","finding":"","journal":"Archiv der Pharmazie","studyType":"Clinical Study"},{"pmid":"41518180","year":"2025","title":"Design, docking study, synthesis and preliminary cytotoxic study of novel Isatin-Niflumic acid derivatives as possible VEGFR tyrosine kinase inhibitors.","finding":"","journal":"Wiadomosci lekarskie (Warsaw, Poland : 1960)","studyType":"Clinical Study"},{"pmid":"41488820","year":"2025","title":"Metabolic Regulatory Mechanism of Gastric Motility by Acetylcholine.","finding":"","journal":"Gastroenterology research","studyType":"Clinical Study"},{"pmid":"41302422","year":"2025","title":"Duality of Simplicity and Accuracy in QSPR: A Machine Learning Framework for Predicting Solubility of Selected Pharmaceutical Acids in Deep Eutectic Solvents.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"}],"tags":[{"label":"niflumic acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Potassium channel subfamily T member 2","category":"target"},{"label":"KCNT2","category":"gene"},{"label":"TTR","category":"gene"},{"label":"PTGS2","category":"gene"},{"label":"M01AX02","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Cyclooxygenase Inhibitors","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":67.813,"date":"","count":9,"signal":"Aspirin-exacerbated respiratory disease","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=68)"}],"commonSideEffects":[{"effect":"Aspirin-exacerbated respiratory disease","drugRate":"LLR 68","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"niflamol","offLabel":[],"synonyms":["niflumic acid","niflamol","nifluminic acid"],"timeline":[],"approvals":[],"brandName":"Niflamol","ecosystem":[],"mechanism":{"target":"Chloride channel protein ClC-Ka, Chloride channel protein ClC-Kb, Potassium channel subfamily T member 2","targets":[{"gene":"KCNT2","source":"DrugCentral","target":"Potassium channel subfamily T member 2","protein":"Potassium channel subfamily T member 2"},{"gene":"TTR","source":"DrugCentral","target":"Transthyretin","protein":"Transthyretin"},{"gene":"PTGS2","source":"DrugCentral","target":"Prostaglandin G/H synthase 2","protein":"Prostaglandin G/H synthase 2"},{"gene":"PTGS1","source":"DrugCentral","target":"Prostaglandin G/H synthase 1","protein":"Prostaglandin G/H synthase 1"},{"gene":"GPR35","source":"DrugCentral","target":"G-protein coupled receptor 35","protein":"G-protein coupled receptor 35"},{"gene":"CLCNKA","source":"DrugCentral","target":"Chloride channel protein ClC-Ka","protein":"Chloride channel protein ClC-Ka"},{"gene":"CLCNKB","source":"DrugCentral","target":"Chloride channel protein ClC-Kb","protein":"Chloride channel protein ClC-Kb"},{"gene":"DHODH","source":"DrugCentral","target":"Dihydroorotate dehydrogenase (quinone), mitochondrial","protein":"Dihydroorotate dehydrogenase (quinone), mitochondrial"},{"gene":"TEAD4","source":"DrugCentral","target":"Transcriptional enhancer factor TEF-3","protein":"Transcriptional enhancer factor TEF-3"}],"modality":"Small Molecule","drugClass":"niflumic acid","explanation":"Imagine your body's cells are like a fire station, and inflammation is like a fire. Potassium channels help control the flow of information between cells, but when they're overactive, it's like the fire alarm is going off too much. Niflumic acid helps calm down the potassium channels, reducing the inflammation and 'fire' in the body.","oneSentence":"Niflumic acid works by blocking potassium channels to reduce inflammation.","technicalDetail":"Niflumic acid acts as a selective blocker of the KCNT2 potassium channel, inhibiting its activity and reducing the flow of potassium ions, which in turn decreases the excitability of neurons and reduces inflammation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1925","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=NIFLUMIC%20ACID","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NIFLUMIC ACID","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:57:41.111284","biosimilars":[],"competitors":[{"drugName":"nabumetone","drugSlug":"nabumetone","fdaApproval":"1991-12-24","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"glucosamine","drugSlug":"glucosamine","fdaApproval":"","relationship":"same-class"},{"drugName":"orgotein","drugSlug":"orgotein","fdaApproval":"","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"niflumic acid","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nabumetone","brandName":"nabumetone","genericName":"nabumetone","approvalYear":"1991","relationship":"same-class"},{"drugId":"glucosamine","brandName":"glucosamine","genericName":"glucosamine","approvalYear":"","relationship":"same-class"},{"drugId":"orgotein","brandName":"orgotein","genericName":"orgotein","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05761015","phase":"PHASE4","title":"Helping Osteoarthritis Patients to Walk With NSAID","status":"RECRUITING","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2023-12-14","conditions":["Osteoarthritis, Knee","Osteoarthritis, Hip","Chronic Pain"],"enrollment":55,"completionDate":"2028-04"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000167326","NDDF":"005830","UNII":"4U5MP5IUD8","CHEBI":"CHEBI:34888","INN_ID":"2194","RXNORM":"7418","UMLSCUI":"C0028067","ChEMBL_ID":"CHEMBL63323","KEGG_DRUG":"D08275","DRUGBANK_ID":"DB04552","PDB_CHEM_ID":"NFL","PUBCHEM_CID":"4488","IUPHAR_LIGAND_ID":"2439","MESH_DESCRIPTOR_UI":"D009544"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1157,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AX02","allCodes":["M01AX02","M02AA17"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jun 5","pmid":"41763020","title":"Dual-functional near-infrared fluorescent probe for H(2)S detection and precise COX-2-positive cancer imaging.","journal":"Bioorganic chemistry"},{"date":"2026 Feb","pmid":"41656545","title":"Harnessing Hybrid Chemistry: Novel Ethyl Ferulate Ester of Niflumic Acid for Enhanced Therapeutic Benefits.","journal":"Archiv der Pharmazie"},{"date":"2025","pmid":"41518180","title":"Design, docking study, synthesis and preliminary cytotoxic study of novel Isatin-Niflumic acid derivatives as possible VEGFR tyrosine kinase inhibitors.","journal":"Wiadomosci lekarskie (Warsaw, Poland : 1960)"},{"date":"2025 Dec","pmid":"41488820","title":"Metabolic Regulatory Mechanism of Gastric Motility by Acetylcholine.","journal":"Gastroenterology research"},{"date":"2025 Nov 11","pmid":"41302422","title":"Duality of Simplicity and Accuracy in QSPR: A Machine Learning Framework for Predicting Solubility of Selected Pharmaceutical Acids in Deep Eutectic Solvents.","journal":"Molecules (Basel, Switzerland)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Niflamol is a small molecule medication. It is also known by other names, including Niflumic acid, Niflumatic acid, and Niflumatico.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}