{"id":"nifenazone","rwe":[{"pmid":"33106653","year":"2020","title":"The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin.","finding":"","journal":"Nature cell biology","studyType":"Clinical Study"},{"pmid":"31797568","year":"2020","title":"Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity.","finding":"","journal":"ChemMedChem","studyType":"Clinical Study"},{"pmid":"24954054","year":"2014","title":"The solvatochromic, spectral, and geometrical properties of nifenazone: a DFT/TD-DFT and experimental study.","finding":"","journal":"Physical chemistry chemical physics : PCCP","studyType":"Clinical Study"},{"pmid":"2935118","year":"1985","title":"[Nifenazone, biotransformation in humans].","finding":"","journal":"Archiv der Pharmazie","studyType":"Clinical Study"},{"pmid":"3991782","year":"1985","title":"Photochemical decomposition of phenazone derivatives. Part 5(1): Isolation and identification of decomposition products in aqueous solution.","finding":"","journal":"Die Pharmazie","studyType":"Clinical Study"}],"tags":[{"label":"nifenazone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M02AA24","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"niapyrin","offLabel":[],"synonyms":["nifenazone dihydrochloride","nikofezon","nifenazone","nicophesone","niapyrin","nicazane","nicodone","nicofesone","nicophezon","nicotazone","nifenazon","phenicazone","niprazine"],"timeline":[],"approvals":[],"brandName":"Niapyrin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"nifenazone","explanation":"Imagine your cells are like a orchestra, and nifenazone is like a conductor that helps the different parts work together in harmony. However, the specific way it conducts the orchestra is not well understood. More research is needed to figure out how it works and what it does.","oneSentence":"Nifenazone is thought to work by modulating cellular processes, although the exact mechanism is unknown.","technicalDetail":"Nifenazone's mechanism of action is believed to involve the modulation of cellular signaling pathways, although the specific molecular targets and mechanisms involved are currently unknown."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1924","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NIFENAZONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:39:32.603680","biosimilars":[],"competitors":[{"drugName":"phenylbutazone","drugSlug":"phenylbutazone","fdaApproval":"1980-01-10","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxyphenbutazone","drugSlug":"oxyphenbutazone","fdaApproval":"1960-12-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"piroxicam","drugSlug":"piroxicam","fdaApproval":"1982-04-06","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketoprofen","drugSlug":"ketoprofen","fdaApproval":"1986-01-09","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"naproxen","drugSlug":"naproxen","fdaApproval":"1976-03-11","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ibuprofen","drugSlug":"ibuprofen","fdaApproval":"1974-09-19","patentExpiry":"Sep 30, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"diclofenac","drugSlug":"diclofenac","fdaApproval":"1988-07-28","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"meclofenamic acid","drugSlug":"meclofenamic-acid","fdaApproval":"1980-06-25","relationship":"same-class"},{"drugName":"flurbiprofen","drugSlug":"flurbiprofen","fdaApproval":"1986-12-31","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tolmetin","drugSlug":"tolmetin","fdaApproval":"1976-03-24","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"indomethacin","drugSlug":"indomethacin","fdaApproval":"1965-06-10","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"aceclofenac","drugSlug":"aceclofenac","fdaApproval":"","relationship":"same-class"}],"genericName":"nifenazone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phenylbutazone","brandName":"phenylbutazone","genericName":"phenylbutazone","approvalYear":"1980","relationship":"same-class"},{"drugId":"oxyphenbutazone","brandName":"oxyphenbutazone","genericName":"oxyphenbutazone","approvalYear":"1960","relationship":"same-class"},{"drugId":"piroxicam","brandName":"piroxicam","genericName":"piroxicam","approvalYear":"1982","relationship":"same-class"},{"drugId":"ketoprofen","brandName":"ketoprofen","genericName":"ketoprofen","approvalYear":"1986","relationship":"same-class"},{"drugId":"naproxen","brandName":"naproxen","genericName":"naproxen","approvalYear":"1976","relationship":"same-class"},{"drugId":"ibuprofen","brandName":"ibuprofen","genericName":"ibuprofen","approvalYear":"1974","relationship":"same-class"},{"drugId":"diclofenac","brandName":"diclofenac","genericName":"diclofenac","approvalYear":"1988","relationship":"same-class"},{"drugId":"meclofenamic-acid","brandName":"meclofenamic acid","genericName":"meclofenamic acid","approvalYear":"1980","relationship":"same-class"},{"drugId":"flurbiprofen","brandName":"flurbiprofen","genericName":"flurbiprofen","approvalYear":"1986","relationship":"same-class"},{"drugId":"tolmetin","brandName":"tolmetin","genericName":"tolmetin","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"8780F0K71U","CHEBI":"CHEBI:31910","INN_ID":"1834","UMLSCUI":"C0068738","ChEMBL_ID":"CHEMBL1413176","KEGG_DRUG":"D01437","DRUGBANK_ID":"DB13407","PUBCHEM_CID":"4487","SECONDARY_CAS_RN":"51658-08-3","MESH_SUPPLEMENTAL_RECORD_UI":"C005249"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"M02AA24","allCodes":["M02AA24","N02BB05"]},"biosimilarFilings":[],"recentPublications":[{"date":"2020 Nov","pmid":"33106653","title":"The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin.","journal":"Nature cell biology"},{"date":"2020 Feb 5","pmid":"31797568","title":"Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity.","journal":"ChemMedChem"},{"date":"2014 Aug 7","pmid":"24954054","title":"The solvatochromic, spectral, and geometrical properties of nifenazone: a DFT/TD-DFT and experimental study.","journal":"Physical chemistry chemical physics : PCCP"},{"date":"1985 Sep","pmid":"2935118","title":"[Nifenazone, biotransformation in humans].","journal":"Archiv der Pharmazie"},{"date":"1985 Jan","pmid":"3991782","title":"Photochemical decomposition of phenazone derivatives. Part 5(1): Isolation and identification of decomposition products in aqueous solution.","journal":"Die Pharmazie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nifenazone, also known as Niapyrin, is a small molecule drug of the nifenazone class. Its exact target and mechanism of action are unknown, but it is believed to work by modulating certain cellular processes. Nifenazone is not FDA-approved for any indications, and its commercial status, including patent and generic availability, is unclear. Further research is needed to fully understand its safety profile and potential therapeutic applications. As a result, it is not currently used in clinical practice.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}