{"id":"nifenalol","rwe":[{"pmid":"31784998","year":"2020","title":"Enantioconvergent hydrolysis of m-nitrostyrene oxide at an elevated concentration by Phaseolus vulgaris epoxide hydrolase in the organic/aqueous two-phase system.","finding":"","journal":"Letters in applied microbiology","studyType":"Clinical Study"},{"pmid":"8896710","year":"1996","title":"Arrhythmogenic effect of beta-adrenoceptor-blocking drugs in Purkinje fibres of guinea-pig hearts.","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"},{"pmid":"2872598","year":"1986","title":"Effects of bucumolol, nadolol and nifenalol on maximum upstroke velocity of action potential in guinea pig papillary muscles.","finding":"","journal":"Naunyn-Schmiedeberg's archives of pharmacology","studyType":"Clinical Study"},{"pmid":"6895689","year":"1981","title":"[Action of propranolol, nifenalol, and pindolol on the lipolytic effect of adrenaline in the rat epididymis].","finding":"","journal":"Archivos de farmacologia y toxicologia","studyType":"Clinical Study"},{"pmid":"196150","year":"1977","title":"Differentiation of beta-adrenoceptors in right atrium, diaphragm and adipose tissue of the rat, using stereoisomers of propranolol, alprenolol, nifenalol and practolol.","finding":"","journal":"Life sciences","studyType":"Clinical Study"}],"tags":[{"label":"nifenalol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"isophenethanol","offLabel":[],"synonyms":["nifenalol","isophenethanol","racemic nifenalol"],"timeline":[],"approvals":[],"brandName":"Isophenethanol","ecosystem":[],"mechanism":{"target":"Beta-2 adrenergic receptor","modality":"Small Molecule","drugClass":"nifenalol","explanation":"Imagine your body's cells as a complex network of roads and intersections. Nifenalol is like a traffic controller that helps regulate the flow of signals between cells, but we don't know exactly how it does this or which roads it affects.","oneSentence":"Nifenalol is thought to work by interacting with cellular pathways, although the exact mechanism is unknown.","technicalDetail":"Nifenalol is a small molecule that binds to and modulates the activity of specific proteins or receptors, potentially influencing downstream signaling pathways and cellular responses."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3380","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NIFENALOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:57:37.147430","biosimilars":[],"competitors":[{"drugName":"betaxolol","drugSlug":"betaxolol","fdaApproval":"1985-08-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"clenbuterol","drugSlug":"clenbuterol","fdaApproval":"","relationship":"same-target"},{"drugName":"isoprenaline","drugSlug":"isoprenaline","fdaApproval":"1956-03-09","relationship":"same-target"},{"drugName":"norepinephrine","drugSlug":"norepinephrine","fdaApproval":"1950-07-13","patentExpiry":"Mar 8, 2041","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"orciprenaline","drugSlug":"orciprenaline","fdaApproval":"1973-07-31","relationship":"same-target"},{"drugName":"propranolol","drugSlug":"propranolol","fdaApproval":"1967-11-13","patentExpiry":"Oct 16, 2028","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"salbutamol","drugSlug":"salbutamol","fdaApproval":"1981-05-01","relationship":"same-target"},{"drugName":"sotalol","drugSlug":"sotalol","fdaApproval":"1992-10-30","patentExpiry":"Nov 19, 2034","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"terbutaline","drugSlug":"terbutaline","fdaApproval":"1974-03-25","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"nifenalol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"betaxolol","brandName":"betaxolol","genericName":"betaxolol","approvalYear":"1985","relationship":"same-target"},{"drugId":"clenbuterol","brandName":"clenbuterol","genericName":"clenbuterol","approvalYear":"","relationship":"same-target"},{"drugId":"isoprenaline","brandName":"isoprenaline","genericName":"isoprenaline","approvalYear":"1956","relationship":"same-target"},{"drugId":"norepinephrine","brandName":"norepinephrine","genericName":"norepinephrine","approvalYear":"1950","relationship":"same-target"},{"drugId":"orciprenaline","brandName":"orciprenaline","genericName":"orciprenaline","approvalYear":"1973","relationship":"same-target"},{"drugId":"propranolol","brandName":"propranolol","genericName":"propranolol","approvalYear":"1967","relationship":"same-target"},{"drugId":"salbutamol","brandName":"salbutamol","genericName":"salbutamol","approvalYear":"1981","relationship":"same-target"},{"drugId":"sotalol","brandName":"sotalol","genericName":"sotalol","approvalYear":"1992","relationship":"same-target"},{"drugId":"terbutaline","brandName":"terbutaline","genericName":"terbutaline","approvalYear":"1974","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"D1DE63830P","CHEBI":"CHEBI:134921","INN_ID":"2734","UMLSCUI":"C0068737","ChEMBL_ID":"CHEMBL127349","PUBCHEM_CID":"6317","MESH_SUPPLEMENTAL_RECORD_UI":"C100250"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":8,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2020 Mar","pmid":"31784998","title":"Enantioconvergent hydrolysis of m-nitrostyrene oxide at an elevated concentration by Phaseolus vulgaris epoxide hydrolase in the organic/aqueous two-phase system.","journal":"Letters in applied microbiology"},{"date":"1996 Jan-Feb","pmid":"8896710","title":"Arrhythmogenic effect of beta-adrenoceptor-blocking drugs in Purkinje fibres of guinea-pig hearts.","journal":"Archives internationales de pharmacodynamie et de therapie"},{"date":"1986 Mar","pmid":"2872598","title":"Effects of bucumolol, nadolol and nifenalol on maximum upstroke velocity of action potential in guinea pig papillary muscles.","journal":"Naunyn-Schmiedeberg's archives of pharmacology"},{"date":"1981 Apr","pmid":"6895689","title":"[Action of propranolol, nifenalol, and pindolol on the lipolytic effect of adrenaline in the rat epididymis].","journal":"Archivos de farmacologia y toxicologia"},{"date":"1977 Jul 1","pmid":"196150","title":"Differentiation of beta-adrenoceptors in right atrium, diaphragm and adipose tissue of the rat, using stereoisomers of propranolol, alprenolol, nifenalol and practolol.","journal":"Life sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Isophenethanol, also known as Nifenalol, is a small molecule drug of the nifenalol class. Its exact target and mechanism of action are unknown, but it is believed to work by interacting with certain cellular pathways. Nifenalol is not FDA-approved for any indications, and its commercial status, including patent and generic availability, is unclear. Further research is needed to determine its safety and efficacy. As a result, there is limited information available on its half-life, bioavailability, and potential side effects.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}