{"id":"nifedipine-telmisartan","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Peripheral edema"},{"rate":"5-10","effect":"Headache"},{"rate":"3-7","effect":"Dizziness"},{"rate":"3-5","effect":"Flushing"},{"rate":"2-5","effect":"Fatigue"},{"rate":"1-3","effect":"Hyperkalemia"}]},"_chembl":{"chemblId":"CHEMBL1017","moleculeType":"Small molecule","molecularWeight":"514.63"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nifedipine is a dihydropyridine calcium channel blocker that inhibits L-type calcium channels in vascular smooth muscle, causing vasodilation. Telmisartan is an angiotensin II receptor blocker (ARB) that antagonizes AT1 receptors, preventing angiotensin II-mediated vasoconstriction and sodium retention. Together, they provide complementary antihypertensive effects through different mechanisms.","oneSentence":"This combination reduces blood pressure by blocking calcium channels (nifedipine) to relax blood vessels and blocking angiotensin II receptors (telmisartan) to prevent vasoconstriction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:43.668Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT07262710","phase":"","title":"Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study","status":"NOT_YET_RECRUITING","sponsor":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","startDate":"2025-12-01","conditions":"Post-stroke Pneumonia","enrollment":13656},{"nctId":"NCT04467931","phase":"","title":"ACEI or ARB and COVID-19 Severity and Mortality in US Veterans","status":"COMPLETED","sponsor":"University of Utah","startDate":"2020-01-19","conditions":"Hypertension, COVID","enrollment":22213},{"nctId":"NCT04330300","phase":"PHASE4","title":"Coronavirus (COVID-19) ACEi/ARB Investigation","status":"SUSPENDED","sponsor":"National University of Ireland, Galway, Ireland","startDate":"2020-04-30","conditions":"Hypertension, COVID-19","enrollment":2414},{"nctId":"NCT00750113","phase":"PHASE4","title":"Study Evaluating the Efficacy of Nifedipine GITS - Telmisartan Combination in Blood Pressure Control.","status":"COMPLETED","sponsor":"Bayer","startDate":"2007-10","conditions":"Hypertension","enrollment":405},{"nctId":"NCT01830530","phase":"PHASE4","title":"HIGH Altitude CArdiovascular REsearch in the ANDES","status":"COMPLETED","sponsor":"Istituto Auxologico Italiano","startDate":"2012-05","conditions":"Hypertension, High Altitude","enrollment":100},{"nctId":"NCT01435161","phase":"PHASE4","title":"Nifedipine vs Telmisartan on Prevention of Atrial Fibrillation (AF) Recurrence in Hypertensive Patients With AF","status":"COMPLETED","sponsor":"The Second Affiliated Hospital of Chongqing Medical University","startDate":"2007-05","conditions":"Atrial Fibrillation","enrollment":160},{"nctId":"NCT00684489","phase":"NA","title":"Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2003-09","conditions":"Hypertension","enrollment":52}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Nifedipine/Telmisartan","genericName":"Nifedipine/Telmisartan","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination reduces blood pressure by blocking calcium channels (nifedipine) to relax blood vessels and blocking angiotensin II receptors (telmisartan) to prevent vasoconstriction. Used for Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}