{"id":"nifedipine-cream-topical-application","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or erythema"},{"rate":null,"effect":"Headache (from systemic absorption)"},{"rate":null,"effect":"Flushing"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nifedipine inhibits L-type calcium channels in vascular smooth muscle cells, reducing intracellular calcium and causing vasodilation. When formulated as a topical cream, it is applied locally to increase blood perfusion and reduce ischemic pain, particularly in conditions affecting peripheral blood vessels. The topical route allows direct local action while minimizing systemic exposure.","oneSentence":"Nifedipine is a calcium channel blocker that relaxes vascular smooth muscle and improves blood flow when applied topically to affected tissues.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:23:11.533Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anal fissures (chronic pain and healing promotion)"},{"name":"Raynaud's phenomenon (topical vasodilation)"}]},"trialDetails":[{"nctId":"NCT07295886","phase":"","title":"Topical Nifedipine 0.3% Plus Lidocaine 1.5% for Uncomplicated Hemorrhoidal Disease","status":"RECRUITING","sponsor":"Cardarelli Hospital","startDate":"2025-09-02","conditions":"Hemorrhoid Bleeding, Hemorrhoids Prolapse, Hemorrhoid Pain","enrollment":80},{"nctId":"NCT03027674","phase":"EARLY_PHASE1","title":"Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud","status":"COMPLETED","sponsor":"Pontificia Universidad Catolica de Chile","startDate":"2016-08","conditions":"Raynaud Phenomenon Due to Trauma, Raynaud Disease, System; Sclerosis","enrollment":10},{"nctId":"NCT00496184","phase":"PHASE3","title":"Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis","status":"COMPLETED","sponsor":"Western Galilee Hospital-Nahariya","startDate":"2006-04","conditions":"Vulvar Diseases, Vulvar Pain, Vestibulitis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Nifedipine cream topical application","genericName":"Nifedipine cream topical application","companyName":"Western Galilee Hospital-Nahariya","companyId":"western-galilee-hospital-nahariya","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nifedipine is a calcium channel blocker that relaxes vascular smooth muscle and improves blood flow when applied topically to affected tissues. Used for Anal fissures (chronic pain and healing promotion), Raynaud's phenomenon (topical vasodilation).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}