{"id":"nicotine-transdermal-patch","safety":{"commonSideEffects":[{"rate":"15-20","effect":"Skin irritation at patch application site"},{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Sleep disturbances"},{"rate":"5-10","effect":"Vivid dreams"}]},"_chembl":{"chemblId":"CHEMBL3989563","moleculeType":"Small molecule","molecularWeight":"498.44"},"_dailymed":{"setId":"457c860b-091d-8350-e063-6294a90a2f98","title":"AROAMAS COT NICOTINE TRANSDERMAL PATCHES STEP 1 (NICOTINE TRANSDERMAL PATCHES) PATCH [PCHEERY LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The transdermal patch delivers nicotine through the skin at a controlled rate, maintaining steady-state plasma levels throughout the day. This activation of nicotinic acetylcholine receptors mimics the effects of smoked tobacco, reducing the severity of withdrawal symptoms such as irritability, anxiety, difficulty concentrating, and cravings. The patch formulation allows for gradual dose reduction over time to facilitate smoking cessation.","oneSentence":"Nicotine binds to nicotinic acetylcholine receptors in the central and peripheral nervous system, providing nicotine replacement to reduce withdrawal symptoms and cravings in tobacco users.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:12.413Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation as an aid to quit smoking"},{"name":"Reduction of nicotine withdrawal symptoms in tobacco-dependent individuals"}]},"trialDetails":[{"nctId":"NCT05004662","phase":"NA","title":"Partnering With Food Bank to Provide Tobacco Treatment to Underserved Smokers","status":"COMPLETED","sponsor":"H. 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