{"id":"nicotine-replacement-therapy-nicotine-gum","safety":{"commonSideEffects":[{"rate":null,"effect":"Mouth and throat irritation"},{"rate":null,"effect":"Hiccups"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Jaw soreness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL3989563","moleculeType":"Small molecule","molecularWeight":"498.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nicotine acts as an agonist at nicotinic acetylcholine receptors, particularly in the mesolimbic dopamine pathway, which mediates reward and addiction. By providing exogenous nicotine without the harmful combustion byproducts of cigarettes, the gum reduces the severity of withdrawal symptoms and cravings, facilitating abstinence. The gradual tapering of nicotine dose allows patients to progressively reduce dependence.","oneSentence":"Nicotine gum delivers nicotine through the oral mucosa to bind nicotinic acetylcholine receptors in the brain, reducing cravings and withdrawal symptoms during smoking cessation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:23:00.548Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nicotine dependence / smoking cessation"}]},"trialDetails":[{"nctId":"NCT05515354","phase":"PHASE4","title":"Smoking Cessation and Menstrual Cycle Phase","status":"RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2022-11-30","conditions":"Nicotine Dependence, Tobacco Smoking, Smoking Cessation","enrollment":1200},{"nctId":"NCT03249428","phase":"NA","title":"Cytisine vs Nicotine Replacement Therapy","status":"ENROLLING_BY_INVITATION","sponsor":"Ottawa Hospital Research Institute","startDate":"2025-11-04","conditions":"Tobacco Dependence, COPD Asthma, Mental Illness","enrollment":200},{"nctId":"NCT06945120","phase":"NA","title":"ACT Lung Health Intervention: Phase Two","status":"RECRUITING","sponsor":"Dana-Farber Cancer Institute","startDate":"2025-11-04","conditions":"Smoking Cessation, Smoking Behaviors, Smoking, Tobacco","enrollment":50},{"nctId":"NCT06811038","phase":"PHASE3","title":"iCanQuit Smoking Cessation Among Hispanic Adults","status":"NOT_YET_RECRUITING","sponsor":"Fred Hutchinson Cancer Center","startDate":"2026-04-01","conditions":"Cigarette Smoking-Related Carcinoma","enrollment":854},{"nctId":"NCT06966362","phase":"PHASE4","title":"Varenicline for Smoking Reduction in Veterans Not Ready To Quit","status":"NOT_YET_RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2026-07-01","conditions":"Veterans, Tobacco Use Disorder, Cigarette Smoking","enrollment":400},{"nctId":"NCT07466875","phase":"NA","title":"Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients","status":"NOT_YET_RECRUITING","sponsor":"Chiao-Chiao Liao","startDate":"2026-04-01","conditions":"Nicotine Dependence, Nicotine Withdrawal, Tobacco Use Disorder","enrollment":60},{"nctId":"NCT04881630","phase":"NA","title":"Mobile Contingency Management for Smoking Cessation","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Oklahoma","startDate":"2022-11-08","conditions":"Smoking Cessation","enrollment":532},{"nctId":"NCT06832085","phase":"PHASE4","title":"Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation","status":"RECRUITING","sponsor":"Ottawa Heart Institute Research Corporation","startDate":"2025-04-30","conditions":"Tobacco","enrollment":150},{"nctId":"NCT07447635","phase":"NA","title":"Testing an MBI for Smoking Cessation and Alcohol Use Among Cancer Survivors","status":"NOT_YET_RECRUITING","sponsor":"H. Lee Moffitt Cancer Center and Research Institute","startDate":"2026-02","conditions":"Smoking Cessation, Alcohol Use","enrollment":600},{"nctId":"NCT05030272","phase":"NA","title":"Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2021-09-21","conditions":"Tobacco Use Disorder, Mental Illness, Recurring Major Depressive Disorder","enrollment":343},{"nctId":"NCT05723588","phase":"PHASE2","title":"Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2023-10-31","conditions":"Tobacco Use Disorder","enrollment":50},{"nctId":"NCT07412717","phase":"NA","title":"The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit.","status":"NOT_YET_RECRUITING","sponsor":"Poitiers University Hospital","startDate":"2026-03-01","conditions":"Nicotine Replacement Therapy, Healthcare Professionals, Tobacco Craving","enrollment":80},{"nctId":"NCT04634071","phase":"PHASE2","title":"Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment","status":"COMPLETED","sponsor":"Joseph Valentino, MD","startDate":"2021-01-12","conditions":"Smoking Cessation, Cancer, Treatment-Related","enrollment":126},{"nctId":"NCT07220356","phase":"PHASE4","title":"C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2025-12-10","conditions":"Tobacco Dependence","enrollment":30},{"nctId":"NCT06545669","phase":"PHASE4","title":"C-Raven, a Virtual Tobacco Cessation Intervention in the Community","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2024-10-30","conditions":"Tobacco Dependence","enrollment":10},{"nctId":"NCT06943287","phase":"NA","title":"Pharmacist Intervention to Improve Smoking Cessation","status":"ENROLLING_BY_INVITATION","sponsor":"University of Iowa","startDate":"2025-08-11","conditions":"Smoking Cessation","enrollment":100},{"nctId":"NCT04889638","phase":"NA","title":"Tobacco Cessation in Public Housing","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2024-04-03","conditions":"Smoking Cessation, Smoking Reduction, Smoking, Tobacco","enrollment":18},{"nctId":"NCT04490057","phase":"PHASE4","title":"A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV","status":"COMPLETED","sponsor":"Yale University","startDate":"2020-07-27","conditions":"Tobacco Use Cessation","enrollment":323},{"nctId":"NCT05589220","phase":"NA","title":"Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Students","status":"RECRUITING","sponsor":"Poitiers University Hospital","startDate":"2022-12-13","conditions":"Smoking Cessation","enrollment":120},{"nctId":"NCT06534047","phase":"PHASE4","title":"Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial","status":"RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2024-09-01","conditions":"Tobacco Use Disorder, Psychiatric Disorder, Nicotine Dependence","enrollment":40},{"nctId":"NCT07148232","phase":"PHASE4","title":"Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2025-11-14","conditions":"Tobacco Cessation, Tobacco Abstinence, Tobacco Use","enrollment":150},{"nctId":"NCT07075575","phase":"NA","title":"Quit-Smoking Study for Native Hawaiians","status":"RECRUITING","sponsor":"University of Hawaii","startDate":"2025-11-01","conditions":"Tobacco Use Disorder, Smoking Cessation","enrollment":75},{"nctId":"NCT04604509","phase":"PHASE4","title":"Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2020-08-04","conditions":"Cigarette Smoking-Related Carcinoma","enrollment":2010},{"nctId":"NCT05815199","phase":"NA","title":"E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2023-11-13","conditions":"Cigarette Smoking","enrollment":60},{"nctId":"NCT02020005","phase":"NA","title":"Evaluation of Cessation Preferences of Menthol Smoker","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2013-09","conditions":"Smoking Cessation","enrollment":60},{"nctId":"NCT04199117","phase":"PHASE4","title":"Health Systems Reach Interventions Project","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2020-03-11","conditions":"Smoking, Cigarette, Smoking Cessation","enrollment":210},{"nctId":"NCT06289192","phase":"PHASE4","title":"Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2024-04-30","conditions":"Tobacco Dependence","enrollment":5},{"nctId":"NCT04694846","phase":"NA","title":"Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2020-08-19","conditions":"Lung Non-Small Cell Carcinoma, Head and Neck Squamous Cell Carcinoma","enrollment":19},{"nctId":"NCT06098144","phase":"PHASE4","title":"Smoking Cessation Program in the Construction Sector","status":"RECRUITING","sponsor":"University of Miami","startDate":"2024-04-10","conditions":"Smoking Cessation, Tobacco Use Cessation, Tobacco Smoking","enrollment":608},{"nctId":"NCT07059377","phase":"PHASE3","title":"Semaglutide for Smoking Cessation in Patients With Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Ottawa Heart Institute Research Corporation","startDate":"2025-09","conditions":"Diabetes Mellitus, Type 2, Nicotine Addiction, Tobacco Dependence","enrollment":100},{"nctId":"NCT06820034","phase":"PHASE1, PHASE2","title":"Empowering Cessation ACS South Region","status":"NOT_YET_RECRUITING","sponsor":"University of Oklahoma","startDate":"2025-09","conditions":"Smoking Cessation","enrollment":400},{"nctId":"NCT07097194","phase":"NA","title":"Be A Quitter: Illinois Small Business EX Program Dissemination","status":"COMPLETED","sponsor":"University of Illinois at Urbana-Champaign","startDate":"2021-11-19","conditions":"Tobacco Use","enrollment":28},{"nctId":"NCT05162911","phase":"NA","title":"Implementing Tobacco Use Treatment in HIV Clinics Vietnam","status":"ACTIVE_NOT_RECRUITING","sponsor":"New York University","startDate":"2021-11-23","conditions":"Tobacco Use","enrollment":672},{"nctId":"NCT05413122","phase":"PHASE2, PHASE3","title":"Evaluating Smoking Cessation Interventions for PWH in South Africa","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2023-11-27","conditions":"Smoking Cessation, HIV, Comorbidities and Coexisting Conditions","enrollment":660},{"nctId":"NCT05154669","phase":"PHASE3","title":"Integrating Financial Coaching and Smoking Cessation Coaching","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2022-12-08","conditions":"Smoking","enrollment":488},{"nctId":"NCT07014124","phase":"NA","title":"Smoking Cessation for Fathers of Sick Children","status":"RECRUITING","sponsor":"The University of Hong Kong","startDate":"2025-03-18","conditions":"Cigarette Smoking, mHealth Intervention","enrollment":160},{"nctId":"NCT05683821","phase":"NA","title":"BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2023-07-24","conditions":"Quitting Smoking, Smoking Cessation, Smoking, Cigarette","enrollment":12376},{"nctId":"NCT06931054","phase":"NA","title":"Combination of Acupuncture, Auricular Acupressure and Nicotine Replacement Therapy for Smoking Cessation","status":"RECRUITING","sponsor":"The University of Hong Kong","startDate":"2025-05-05","conditions":"Smoking","enrollment":270},{"nctId":"NCT05130788","phase":"NA","title":"WeChat Quit Coach Pilot Study","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2022-02-10","conditions":"Smoking Cessation","enrollment":150},{"nctId":"NCT04994444","phase":"PHASE2, PHASE3","title":"Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts","status":"COMPLETED","sponsor":"Brown University","startDate":"2021-09-01","conditions":"Tobacco Use Cessation","enrollment":49},{"nctId":"NCT06088862","phase":"PHASE3","title":"Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT","status":"TERMINATED","sponsor":"Rose Research Center, LLC","startDate":"2023-12-27","conditions":"Smoking Cessation, Harm Reduction","enrollment":4},{"nctId":"NCT04839198","phase":"NA","title":"Using Machine Learning to Develop Just-in-Time Adaptive Interventions for Smoking Cessation","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2024-02-06","conditions":"Smoking Cessation","enrollment":60},{"nctId":"NCT03398876","phase":"PHASE1","title":"A Study to Assess the Nicotine Pharmacokinetics, Tolerability and Safety With a New Oral Nicotine Replacement Product in Healthy Japanese Smokers","status":"COMPLETED","sponsor":"Janssen Pharmaceutical K.K.","startDate":"2017-12-22","conditions":"Healthy","enrollment":24},{"nctId":"NCT01959607","phase":"NA","title":"Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 (THS 2.2)","status":"COMPLETED","sponsor":"Philip Morris Products S.A.","startDate":"2013-07","conditions":"Smoking","enrollment":65},{"nctId":"NCT04218708","phase":"NA","title":"Electronic Cigarettes as a Harm Reduction Strategy Among People Living With HIV/AIDS","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2021-06-17","conditions":"Nicotine Addiction","enrollment":64},{"nctId":"NCT04063267","phase":"PHASE2","title":"Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2020-10-27","conditions":"Cigarette Smoking, Addiction, E Cig Use","enrollment":48},{"nctId":"NCT06745154","phase":"NA","title":"Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in Homeless Young Adult Smokers","status":"COMPLETED","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2023-06-26","conditions":"Cigarette Smoking-Related Carcinoma","enrollment":27},{"nctId":"NCT04654585","phase":"NA","title":"Preference-based Tools for Smoking Cessation Among Disadvantaged Smokers, a Pragmatic Randomised Controlled Trial","status":"COMPLETED","sponsor":"Société de Formation Thérapeutique du Généraliste - Recherche","startDate":"2021-02-26","conditions":"Smoking, Smoking Cessation","enrollment":167},{"nctId":"NCT05020899","phase":"NA","title":"Quit For Life (QFL): Smoking Cessation Among Chinese Smokers Living With HIV","status":"COMPLETED","sponsor":"Boston Medical Center","startDate":"2022-02-24","conditions":"Smoking Cessation, HIV Infections","enrollment":109},{"nctId":"NCT02823028","phase":"PHASE2","title":"Twitter-enabled Mobile Messaging for Smoking Relapse Prevention (Tweet2Quit)","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2016-10","conditions":"Smoking Cessation","enrollment":980},{"nctId":"NCT04974580","phase":"PHASE4","title":"Research and Innovation to Stop E-cigarette/Vaping in Young Adults","status":"COMPLETED","sponsor":"Ohio State University","startDate":"2021-07-28","conditions":"Nicotine Dependence, E-Cig Use","enrollment":508},{"nctId":"NCT05290025","phase":"NA","title":"Easy Access to Smoking Cessation for People Receiving Opioid Agonist Therapy Who Are Smoking Tobacco","status":"ACTIVE_NOT_RECRUITING","sponsor":"Haukeland University Hospital","startDate":"2022-04-07","conditions":"Smoking Cessation, Substance-Related Disorders","enrollment":266},{"nctId":"NCT03717051","phase":"NA","title":"Use of Nicotine Replacement Therapy (NRT) Sample and Brief Smoking Cessation Advice for Recruiting Smokers","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2018-10-13","conditions":"Smoking Cessation","enrollment":834},{"nctId":"NCT06063421","phase":"NA","title":"Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan","status":"NOT_YET_RECRUITING","sponsor":"Strategic Health Research Limited","startDate":"2024-06-01","conditions":"Smoking Cessation, Electronic Cigarette Use","enrollment":438},{"nctId":"NCT02478697","phase":"NA","title":"Tobacco Treatment for Employable Californians, Total IMPACT Study","status":"COMPLETED","sponsor":"Stanford University","startDate":"2015-10","conditions":"Tobacco Dependence","enrollment":360},{"nctId":"NCT02905656","phase":"NA","title":"Strategies to Promote Cessation in Smokers Who Are Not Ready To Quit","status":"COMPLETED","sponsor":"University of Virginia","startDate":"2016-09","conditions":"Smoking Cessation","enrollment":903},{"nctId":"NCT06130423","phase":"NA","title":"Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Health Staff","status":"UNKNOWN","sponsor":"Poitiers University Hospital","startDate":"2024-02-28","conditions":"Smoking Cessation","enrollment":50},{"nctId":"NCT05469698","phase":"NA","title":"Onsite Tobacco Cessation Treatment for Patients With PAD","status":"UNKNOWN","sponsor":"University of Oklahoma","startDate":"2022-08-16","conditions":"Tobacco Cessation, Peripheral Artery Disease","enrollment":15},{"nctId":"NCT04297332","phase":"NA","title":"Episodic Future Thinking and Future Thinking Priming for Smoking Cessation","status":"TERMINATED","sponsor":"Roswell Park Cancer Institute","startDate":"2020-01-01","conditions":"Tobacco-Related Carcinoma","enrollment":26},{"nctId":"NCT03722966","phase":"PHASE2","title":"Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy (COMBO)","status":"TERMINATED","sponsor":"University of Oklahoma","startDate":"2020-01-07","conditions":"Smoking Cessation","enrollment":34},{"nctId":"NCT03691350","phase":"EARLY_PHASE1","title":"Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs","status":"UNKNOWN","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2018-09-17","conditions":"Cigarette Smoker, Current Every Day Smoker","enrollment":239},{"nctId":"NCT00482690","phase":"NA","title":"Analysis of Aldehyde Biomarkers of Exposure and Host Response","status":"TERMINATED","sponsor":"University of Nebraska","startDate":"2005-08-23","conditions":"Smoking Cessation","enrollment":35},{"nctId":"NCT05758298","phase":"EARLY_PHASE1","title":"Assessing the Use of Nicotine Gum to Decrease Betel Nut Chewing in Saipan","status":"WITHDRAWN","sponsor":"University of Texas Southwestern Medical Center","startDate":"2023-10-01","conditions":"Betel Nut Cessation","enrollment":""},{"nctId":"NCT05060965","phase":"EARLY_PHASE1","title":"Inpatient Smoking Cessation Pilot Program","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2019-10-01","conditions":"Tobacco Use Cessation","enrollment":""},{"nctId":"NCT04717544","phase":"NA","title":"Embedding Comprehensive Smoking Cessation Programs Into Community Clinics","status":"COMPLETED","sponsor":"Friends Research Institute, Inc.","startDate":"2019-10-01","conditions":"Smoking Cessation","enrollment":406},{"nctId":"NCT05740098","phase":"NA","title":"Financial Incentives for Smoking Cessation Among Mothers","status":"COMPLETED","sponsor":"University of Vermont","startDate":"2015-06","conditions":"Cigarette Smoking","enrollment":198},{"nctId":"NCT04135937","phase":"PHASE4","title":"Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH)","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2019-11-18","conditions":"Human Immunodeficiency Virus, Smoking","enrollment":12},{"nctId":"NCT05881083","phase":"NA","title":"Nicotine Replacement Therapy Sampling for Smokers in the Community","status":"UNKNOWN","sponsor":"The University of Hong Kong","startDate":"2023-06-17","conditions":"Tobacco Smoking","enrollment":1014},{"nctId":"NCT04465318","phase":"NA","title":"Electronic Cigarettes as a Harm Reduction Strategy Among Patients With COPD","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2020-11-09","conditions":"COPD","enrollment":146},{"nctId":"NCT03405129","phase":"NA","title":"Project Phoenix: Pilot Intervention for Smokers Who Are Not Ready to Quit Smoking","status":"COMPLETED","sponsor":"University of Oklahoma","startDate":"2018-10-17","conditions":"Smoking Cessation, Motivation","enrollment":152},{"nctId":"NCT04594109","phase":"NA","title":"Development of a Tailored Smoking Cessation Program for Individuals With HIV Infection in Washington, D.C.","status":"COMPLETED","sponsor":"Colorado State University","startDate":"2017-06-30","conditions":"Tobacco Smoking","enrollment":25},{"nctId":"NCT03626064","phase":"NA","title":"The PROMPT Pilot Study","status":"COMPLETED","sponsor":"Ottawa Hospital Research Institute","startDate":"2014-06","conditions":"Tobacco Use Disorder, Tobacco Dependence, Tobacco Use Cessation","enrollment":80},{"nctId":"NCT05484505","phase":"EARLY_PHASE1","title":"Preloaded Combination Nicotine Replacement Therapy on Smoking Cessation of Adult Population in Kazakhstan","status":"UNKNOWN","sponsor":"Nazarbayev University","startDate":"2023-07-01","conditions":"Smoking Cessation, Smoking, Cigarette, Smoking Behaviors","enrollment":200},{"nctId":"NCT05649241","phase":"NA","title":"QuitAid Pilot Feasibility Trial","status":"COMPLETED","sponsor":"University of Virginia","startDate":"2021-08-31","conditions":"Smoking Cessation","enrollment":24},{"nctId":"NCT02721082","phase":"PHASE4","title":"Changing the Default for Tobacco Treatment","status":"COMPLETED","sponsor":"University of Kansas Medical Center","startDate":"2016-09-01","conditions":"Tobacco Use Cessation","enrollment":1000},{"nctId":"NCT03111537","phase":"NA","title":"Methods Project 4: Clinical Trial - Amended","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2015-05","conditions":"Tobacco Smoking","enrollment":264},{"nctId":"NCT04461288","phase":"NA","title":"Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2020-05-01","conditions":"Smoking Cessation, Nicotine Dependence, Tobacco Use","enrollment":121},{"nctId":"NCT03426423","phase":"NA","title":"Diabetes and Smoking Cessation: a Gender-Oriented Study","status":"TERMINATED","sponsor":"Carole Clair","startDate":"2018-03-01","conditions":"Smoking Cessation, Diabetes Type 2","enrollment":48},{"nctId":"NCT04001972","phase":"NA","title":"Interactive Communication Technologies and Nicotine Replacement Therapy Sampling for Smokers","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2019-08-19","conditions":"Smoking Cessation, Tobacco Use Cessation","enrollment":664},{"nctId":"NCT02602288","phase":"NA","title":"Babies Living Safe and Smokefree","status":"COMPLETED","sponsor":"Temple University","startDate":"2016-02","conditions":"Second Hand Tobacco Smoke, Nicotine Dependence","enrollment":396},{"nctId":"NCT02137902","phase":"NA","title":"Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study","status":"COMPLETED","sponsor":"Stanford University","startDate":"2015-06-01","conditions":"Tobacco Dependence","enrollment":299},{"nctId":"NCT02245308","phase":"PHASE4","title":"Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2014-10-01","conditions":"Tobacco Use Disorder, Homelessness","enrollment":133},{"nctId":"NCT02050308","phase":"PHASE3","title":"Web-based Smoking Cessation Program for Tribal College Students","status":"COMPLETED","sponsor":"Won Choi, PhD, MPH","startDate":"2015-05","conditions":"Smoking Cessation","enrollment":251},{"nctId":"NCT00356993","phase":"NA","title":"Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP)","status":"COMPLETED","sponsor":"Centre for Addiction and Mental Health","startDate":"2005-10","conditions":"Smoking","enrollment":6009},{"nctId":"NCT03982576","phase":"NA","title":"Innovations to Prevent Relapse Among Low-income African American Smokers","status":"COMPLETED","sponsor":"Case Comprehensive Cancer Center","startDate":"2019-01-01","conditions":"Smoking Cessation","enrollment":18},{"nctId":"NCT02982772","phase":"NA","title":"Patch Study - Intervention for HIV Positive Smokers","status":"COMPLETED","sponsor":"dr. maria miguez","startDate":"2016-05","conditions":"Smoking Cessation, HIV","enrollment":488},{"nctId":"NCT03671707","phase":"NA","title":"Brief Advice, Nicotine Replacement Therapy Sampling and Active Referral (BANSAR) for Smoking Fathers","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2018-10-10","conditions":"Smoking Cessation, Tobacco Use Cessation","enrollment":1053},{"nctId":"NCT00064844","phase":"PHASE4","title":"Combination Nicotine Replacement for Alcoholic Smokers","status":"COMPLETED","sponsor":"Yale University","startDate":"2002-08","conditions":"Smoking, Alcoholism","enrollment":96},{"nctId":"NCT02995915","phase":"PHASE4","title":"Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking","status":"COMPLETED","sponsor":"Duke University","startDate":"2016-11","conditions":"Smoking Cessation, Alcohol Drinking","enrollment":45},{"nctId":"NCT00701896","phase":"NA","title":"Smoking Cessation Using Motivational Therapy and Varenicline","status":"COMPLETED","sponsor":"Philip Diaz","startDate":"2008-10-03","conditions":"Smoking, HIV Infections","enrollment":294},{"nctId":"NCT03717662","phase":"NA","title":"Promoting Women's Health: A Gender Specific Smoking Cessation Program for Female Smokers in Hong Kong","status":"UNKNOWN","sponsor":"The University of Hong Kong","startDate":"2006-04-01","conditions":"Smoking Cessation","enrollment":480},{"nctId":"NCT02896400","phase":"PHASE3","title":"Optimizing Tobacco Dependence Treatment in the Emergency Department","status":"COMPLETED","sponsor":"Yale University","startDate":"2017-02-13","conditions":"Tobacco Use Disorder","enrollment":1056},{"nctId":"NCT04114526","phase":"NA","title":"Durham Housing Authority (DHA) Community Health Advisor (CHA) Smoking Cessation Project","status":"COMPLETED","sponsor":"Duke University","startDate":"2019-07-19","conditions":"Smoking Cessation","enrollment":31},{"nctId":"NCT02168855","phase":"NA","title":"Cessation in Non-Daily Smokers","status":"COMPLETED","sponsor":"Brian Primack","startDate":"2015-06","conditions":"Smoking","enrollment":505},{"nctId":"NCT03290430","phase":"EARLY_PHASE1","title":"End Nicotine Dependence Clinic","status":"COMPLETED","sponsor":"Case Comprehensive Cancer Center","startDate":"2018-01-09","conditions":"Smoking Cessation","enrollment":56},{"nctId":"NCT02307045","phase":"PHASE4","title":"Effect of Smoking Reduction on Endothelial Glucocalyx and Vascular Function","status":"UNKNOWN","sponsor":"University of Athens","startDate":"2014-12-03","conditions":"Smoking Cessation","enrollment":600},{"nctId":"NCT01967706","phase":"NA","title":"Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 Menthol (THS 2.2 Menthol).","status":"COMPLETED","sponsor":"Philip Morris Products S.A.","startDate":"2013-08","conditions":"Smoking","enrollment":73},{"nctId":"NCT02081144","phase":"PHASE1","title":"Texting to Promote Tobacco Abstinence in Emergency Department Smokers: A Pilot Study","status":"COMPLETED","sponsor":"Yale University","startDate":"2014-05","conditions":"Smoking, Tobacco Abstinence","enrollment":60},{"nctId":"NCT02513069","phase":"NA","title":"Mobile Contingency Management for Smoking Cessation in Returning US Veterans","status":"COMPLETED","sponsor":"Duke University","startDate":"2015-01","conditions":"Smoking, Veterans","enrollment":291},{"nctId":"NCT02873377","phase":"PHASE4","title":"Smoking Cessation in Hispanic Construction Workers","status":"COMPLETED","sponsor":"University of Miami","startDate":"2017-04-13","conditions":"Smoking Cessation","enrollment":134}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Nicotine polacrilix","Nicotine gum"],"phase":"phase_3","status":"active","brandName":"Nicotine replacement therapy - nicotine gum","genericName":"Nicotine replacement therapy - nicotine gum","companyName":"Iowa City Veterans Affairs Medical Center","companyId":"iowa-city-veterans-affairs-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nicotine gum delivers nicotine through the oral mucosa to bind nicotinic acetylcholine receptors in the brain, reducing cravings and withdrawal symptoms during smoking cessation. Used for Nicotine dependence / smoking cessation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}