{"id":"nicotine-polacrilex-lozenge","safety":{"commonSideEffects":[{"rate":null,"effect":"Mouth irritation"},{"rate":null,"effect":"Hiccups"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Jaw soreness"},{"rate":null,"effect":"Heartburn"}]},"_chembl":null,"_dailymed":{"setId":"e0234492-d92d-ee93-493f-1099d4544722","title":"NICOTINE POLACRILEX LOZENGE MINT (NICOTINE POLACRILEX LOZENGE 2 MG) LOZENGE NICOTINE POLACRILEX LOZENGE MINT (NICOTINE POLACRILEX LOZENGE 4 MG) LOZENGE [CHAIN DRUG MARKETING ASSOCIATION INC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nicotine acts as an agonist at nicotinic acetylcholine receptors in the central and peripheral nervous system. The polacrilex formulation is an ion-exchange resin complex that slowly releases nicotine in the mouth, allowing transmucosal absorption. This sustained delivery helps maintain adequate nicotine levels to suppress withdrawal symptoms and reduce the reinforcing effects of smoking.","oneSentence":"Nicotine polacrilex lozenge delivers nicotine through the oral mucosa by binding to nicotinic acetylcholine receptors, providing nicotine replacement to reduce withdrawal symptoms and cravings during smoking cessation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T06:40:37.319Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation aid"},{"name":"Reduction of nicotine withdrawal symptoms"}]},"trialDetails":[{"nctId":"NCT05004662","phase":"NA","title":"Partnering With Food Bank to Provide Tobacco Treatment to Underserved Smokers","status":"COMPLETED","sponsor":"H. 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