{"id":"nicotine-patch-nicotine-gum","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Skin irritation at patch application site"},{"rate":"5-15","effect":"Mouth irritation from gum"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Insomnia"},{"rate":"5","effect":"Hiccups"}]},"_chembl":{"chemblId":"CHEMBL3989563","moleculeType":"Small molecule","molecularWeight":"498.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nicotine is a psychoactive alkaloid that activates nicotinic acetylcholine receptors, particularly in the ventral tegmental area and nucleus accumbens, which are involved in reward and addiction pathways. By providing nicotine through transdermal (patch) and oral (gum) routes, the combination therapy delivers the drug at different rates to manage both acute cravings and sustained withdrawal symptoms. This dual-delivery approach helps smokers transition away from cigarette smoking by satisfying nicotine dependence while avoiding the harmful combustion byproducts of tobacco.","oneSentence":"Nicotine binds to nicotinic acetylcholine receptors in the brain to reduce cravings and withdrawal symptoms during smoking cessation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:10.064Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation in adults"}]},"trialDetails":[{"nctId":"NCT05515354","phase":"PHASE4","title":"Smoking Cessation and Menstrual Cycle Phase","status":"RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2022-11-30","conditions":"Nicotine Dependence, Tobacco Smoking, Smoking Cessation","enrollment":1200},{"nctId":"NCT03249428","phase":"NA","title":"Cytisine vs Nicotine Replacement Therapy","status":"ENROLLING_BY_INVITATION","sponsor":"Ottawa Hospital Research Institute","startDate":"2025-11-04","conditions":"Tobacco Dependence, COPD Asthma, Mental Illness","enrollment":200},{"nctId":"NCT06945120","phase":"NA","title":"ACT Lung Health Intervention: Phase Two","status":"RECRUITING","sponsor":"Dana-Farber Cancer Institute","startDate":"2025-11-04","conditions":"Smoking Cessation, Smoking Behaviors, Smoking, Tobacco","enrollment":50},{"nctId":"NCT06811038","phase":"PHASE3","title":"iCanQuit Smoking Cessation Among Hispanic Adults","status":"NOT_YET_RECRUITING","sponsor":"Fred Hutchinson Cancer Center","startDate":"2026-04-01","conditions":"Cigarette Smoking-Related Carcinoma","enrollment":854},{"nctId":"NCT06966362","phase":"PHASE4","title":"Varenicline for Smoking Reduction in Veterans Not Ready To Quit","status":"NOT_YET_RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2026-07-01","conditions":"Veterans, Tobacco Use Disorder, Cigarette Smoking","enrollment":400},{"nctId":"NCT07466875","phase":"NA","title":"Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients","status":"NOT_YET_RECRUITING","sponsor":"Chiao-Chiao Liao","startDate":"2026-04-01","conditions":"Nicotine Dependence, Nicotine Withdrawal, Tobacco Use Disorder","enrollment":60},{"nctId":"NCT04881630","phase":"NA","title":"Mobile Contingency Management for Smoking Cessation","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Oklahoma","startDate":"2022-11-08","conditions":"Smoking Cessation","enrollment":532},{"nctId":"NCT06832085","phase":"PHASE4","title":"Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation","status":"RECRUITING","sponsor":"Ottawa Heart Institute Research Corporation","startDate":"2025-04-30","conditions":"Tobacco","enrollment":150},{"nctId":"NCT07447635","phase":"NA","title":"Testing an MBI for Smoking Cessation and Alcohol Use Among Cancer Survivors","status":"NOT_YET_RECRUITING","sponsor":"H. 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