{"id":"nicotine-2-mg","safety":{"commonSideEffects":[{"rate":null,"effect":"Mouth and throat irritation"},{"rate":null,"effect":"Hiccups"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Jaw soreness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":{"setId":"6874a9f1-d180-4073-8226-df6e21bcf0b7","title":"HABITROL NICOTINE POLACRILEX 2 MG COATED CINNAMON (NICOTINE POLACRILEX) GUM, CHEWING [DR. REDDY'S LABORATORIES INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nicotine is an alkaloid that acts as an agonist at nicotinic acetylcholine receptors, mimicking the effects of acetylcholine. By delivering controlled doses of nicotine without the harmful combustion products of tobacco, it reduces the reinforcing effects of smoking and alleviates withdrawal symptoms such as irritability, anxiety, and difficulty concentrating. The 2 mg formulation is typically delivered via chewing gum and is designed for gradual dose reduction as part of a smoking cessation program.","oneSentence":"Nicotine binds to nicotinic acetylcholine receptors in the brain and peripheral nervous system, providing nicotine replacement to reduce cravings and withdrawal symptoms during smoking cessation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T05:18:34.061Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Smoking cessation aid"},{"name":"Reduction of nicotine withdrawal symptoms"}]},"trialDetails":[{"nctId":"NCT06356610","phase":"NA","title":"Pharmacokinetic and Subjective Effects of Heated Tobacco Products","status":"COMPLETED","sponsor":"Altria Client Services LLC","startDate":"2024-02-06","conditions":"Tobacco Use","enrollment":80},{"nctId":"NCT05630781","phase":"NA","title":"Orexin s Role in the Neurobiology of Substance Use Disorder","status":"RECRUITING","sponsor":"National Institute on Drug Abuse (NIDA)","startDate":"2023-02-15","conditions":"Nicotine Dependence","enrollment":140},{"nctId":"NCT05538910","phase":"NA","title":"Defining Neurobiological Links Between Substance Use and Mental Illness","status":"RECRUITING","sponsor":"National Institute on Drug Abuse (NIDA)","startDate":"2023-02-02","conditions":"Major Depressive Disorder, Substance Use Disorder, Normal Physiology","enrollment":620},{"nctId":"NCT05610800","phase":"PHASE2","title":"Exenatide for Smoking Cessation and Prevention of Weight Gain","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2022-12-07","conditions":"Smoking Cessation, Weight Gain","enrollment":140},{"nctId":"NCT07487818","phase":"PHASE2, PHASE3","title":"A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation","status":"NOT_YET_RECRUITING","sponsor":"Mayo Clinic","startDate":"2026-04-15","conditions":"Smoking Cessation","enrollment":150},{"nctId":"NCT07487051","phase":"","title":"THRIVE in Sedated Gastrointestinal Endoscopy","status":"COMPLETED","sponsor":"Fatih Sultan Mehmet Training and Research Hospital","startDate":"2025-07-01","conditions":"Hypoxemia, Gastrointestinal Endoscopy","enrollment":222},{"nctId":"NCT05515354","phase":"PHASE4","title":"Smoking Cessation and Menstrual Cycle Phase","status":"RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2022-11-30","conditions":"Nicotine Dependence, Tobacco Smoking, Smoking Cessation","enrollment":1200},{"nctId":"NCT06966362","phase":"PHASE4","title":"Varenicline for Smoking Reduction in Veterans Not Ready To Quit","status":"NOT_YET_RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2026-07-01","conditions":"Veterans, Tobacco Use Disorder, Cigarette Smoking","enrollment":400},{"nctId":"NCT06720909","phase":"NA","title":"Mindfulness And Placebo for Pain (MAPP) Study","status":"RECRUITING","sponsor":"Arizona State University","startDate":"2025-01-27","conditions":"Chronic Pain","enrollment":45},{"nctId":"NCT06584929","phase":"NA","title":"Rural Smoking Cessation","status":"NOT_YET_RECRUITING","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2026-05-01","conditions":"Smoking Cessation","enrollment":272},{"nctId":"NCT05452278","phase":"NA","title":"A Relative Bioavailability Study of Nicotine Delivery From Selected Oral Nicotine Products","status":"COMPLETED","sponsor":"Imperial Brands PLC","startDate":"2021-10-21","conditions":"Healthy Volunteers","enrollment":27},{"nctId":"NCT04965181","phase":"NA","title":"Mindfulness-based Smoking Cessation Enhanced With Mobile Technology","status":"COMPLETED","sponsor":"Georgia State University","startDate":"2021-07-01","conditions":"Cigarette Smoking","enrollment":504},{"nctId":"NCT07165808","phase":"NA","title":"Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches","status":"RECRUITING","sponsor":"Emory University","startDate":"2026-02-13","conditions":"Nicotine Addiction","enrollment":84},{"nctId":"NCT07099638","phase":"PHASE2","title":"Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation","status":"NOT_YET_RECRUITING","sponsor":"University of Oklahoma","startDate":"2026-03","conditions":"Smoking Cessation","enrollment":496},{"nctId":"NCT04525755","phase":"PHASE1, PHASE2","title":"STARS (Smoking Treatment And Remote Sampling) Study","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2021-02-08","conditions":"Smoking, Smoking Cessation, Tobacco Smoking","enrollment":652},{"nctId":"NCT03461874","phase":"NA","title":"ACT Therapy for HF Migraine","status":"COMPLETED","sponsor":"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta","startDate":"2018-03-15","conditions":"Migraine Without Aura","enrollment":64},{"nctId":"NCT02162849","phase":"PHASE4","title":"Reward Sensitivity and Pharmacotherapy for Smoking Cessation","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2015-12-14","conditions":"Tobacco Use Cessation","enrollment":204},{"nctId":"NCT06554873","phase":"PHASE3","title":"Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders","status":"COMPLETED","sponsor":"Rose Research Center, LLC","startDate":"2024-08-29","conditions":"Smoking Cessation, Harm Reduction","enrollment":150},{"nctId":"NCT05587504","phase":"NA","title":"Determination of Liquid Flavor and Nicotine Form Outcomes","status":"COMPLETED","sponsor":"Virginia Commonwealth University","startDate":"2023-07-21","conditions":"Electronic Cigarettes","enrollment":13},{"nctId":"NCT05205811","phase":"PHASE3","title":"The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette","status":"COMPLETED","sponsor":"Rose Research Center, LLC","startDate":"2021-12-14","conditions":"Smoking Cessation","enrollment":180},{"nctId":"NCT04634071","phase":"PHASE2","title":"Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment","status":"COMPLETED","sponsor":"Joseph Valentino, MD","startDate":"2021-01-12","conditions":"Smoking Cessation, Cancer, Treatment-Related","enrollment":126},{"nctId":"NCT07145866","phase":"PHASE4","title":"Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)","status":"NOT_YET_RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2026-03-15","conditions":"Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping","enrollment":30},{"nctId":"NCT05431387","phase":"PHASE2","title":"A Study of Cytisinicline for Vaping Cessation in Adult Smokers","status":"COMPLETED","sponsor":"Achieve Life Sciences","startDate":"2022-07-13","conditions":"Vaping, E-Cig Use","enrollment":160},{"nctId":"NCT07132814","phase":"NA","title":"Abuse Liability for Five Modern Oral Nicotine Products","status":"RECRUITING","sponsor":"RAI Services Company","startDate":"2025-12-15","conditions":"Smoking, Smoking Behaviors, Tobacco Use","enrollment":40},{"nctId":"NCT05703672","phase":"PHASE3","title":"Switching to E-cigarettes in Smokers Not Interested in Quitting","status":"RECRUITING","sponsor":"University of Kansas Medical Center","startDate":"2023-07-17","conditions":"Smoking Reduction","enrollment":500},{"nctId":"NCT07306702","phase":"PHASE4","title":"Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients","status":"COMPLETED","sponsor":"Shenyang Sixth People's Hospital","startDate":"2023-07-01","conditions":"Postoperative Pain Management","enrollment":102},{"nctId":"NCT03630614","phase":"PHASE3","title":"Randomized Trial of Electronic Cigarettes With or Without Nicotine in Smoking Cessation.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2018-10-17","conditions":"Smoking Cessation, Smoking, Cigarette, Electronic Cigarette","enrollment":650},{"nctId":"NCT06678789","phase":"NA","title":"Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2025-02-14","conditions":"Cigarette Smoking, Nicotine Dependence, Smoking Cessation","enrollment":50},{"nctId":"NCT07267195","phase":"NA","title":"Abuse Liability for Four Heated Tobacco Product (HTP) Consumables and Two HTP Devices","status":"NOT_YET_RECRUITING","sponsor":"RAI Services Company","startDate":"2026-01","conditions":"Smoking, Smoking Behaviors, Tobacco Use","enrollment":40},{"nctId":"NCT07254832","phase":"NA","title":"Effects of Caffeine and Nicotine Gum on Balance Performance in Athletes","status":"COMPLETED","sponsor":"Gülbin Rudarlı","startDate":"2024-01-08","conditions":"Athletic Performance, Postural Stability, Healhty","enrollment":20},{"nctId":"NCT04033237","phase":"PHASE1, PHASE2","title":"Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women","status":"COMPLETED","sponsor":"University of Vermont","startDate":"2019-08-21","conditions":"Tobacco Use Disorder","enrollment":30},{"nctId":"NCT06474299","phase":"PHASE4","title":"The Avenues Study: Dual Use Cessation","status":"RECRUITING","sponsor":"University of Wisconsin, Madison","startDate":"2024-09-24","conditions":"Smoking Cessation, Electronic Cigarette Use","enrollment":500},{"nctId":"NCT00494728","phase":"PHASE1, PHASE2","title":"Smoking Cessation for Depressed Smokers","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2007-06-28","conditions":"Smoking, Depression","enrollment":91},{"nctId":"NCT07075575","phase":"NA","title":"Quit-Smoking Study for Native Hawaiians","status":"RECRUITING","sponsor":"University of Hawaii","startDate":"2025-11-01","conditions":"Tobacco Use Disorder, Smoking Cessation","enrollment":75},{"nctId":"NCT06218823","phase":"PHASE4","title":"Tobacco Treatment Comparison for Cancer Care","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2024-03-01","conditions":"Smoking Cessation, Cancer","enrollment":52},{"nctId":"NCT05362318","phase":"NA","title":"Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free","status":"COMPLETED","sponsor":"H. Lee Moffitt Cancer Center and Research Institute","startDate":"2021-06-07","conditions":"Smoking, Tobacco Use, Lung Cancer","enrollment":21},{"nctId":"NCT04199117","phase":"PHASE4","title":"Health Systems Reach Interventions Project","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2020-03-11","conditions":"Smoking, Cigarette, Smoking Cessation","enrollment":210},{"nctId":"NCT05370313","phase":"NA","title":"The Impact of Innovative Tax Proposals on Purchase Patterns","status":"COMPLETED","sponsor":"Virginia Polytechnic Institute and State University","startDate":"2023-04-11","conditions":"Cigarette Smoking","enrollment":285},{"nctId":"NCT02032212","phase":"NA","title":"A Bioavailability Study of Nicotine Delivered by an Electronic Vapour Product","status":"COMPLETED","sponsor":"Imperial Brands PLC","startDate":"2013-12","conditions":"Healthy Volunteers","enrollment":12},{"nctId":"NCT07142668","phase":"NA","title":"Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing","status":"RECRUITING","sponsor":"Virginia Polytechnic Institute and State University","startDate":"2025-08-15","conditions":"Cigarette Smoking","enrollment":316},{"nctId":"NCT06098144","phase":"PHASE4","title":"Smoking Cessation Program in the Construction Sector","status":"RECRUITING","sponsor":"University of Miami","startDate":"2024-04-10","conditions":"Smoking Cessation, Tobacco Use Cessation, Tobacco Smoking","enrollment":608},{"nctId":"NCT07095205","phase":"PHASE4","title":"PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine.","status":"RECRUITING","sponsor":"Stony Brook University","startDate":"2024-10-03","conditions":"Major Depressive Disorder (MDD)","enrollment":14},{"nctId":"NCT04236791","phase":"NA","title":"The ESTxENDS Trial- Electronic Nicotine Delivery Systems as an Aid for Smoking Cessation-extension of Follow-up","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Bern","startDate":"2018-07-16","conditions":"Smoking Cessation","enrollment":1246},{"nctId":"NCT04188873","phase":"PHASE4","title":"Cessation Screening Project","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2020-12-10","conditions":"Nicotine Dependence","enrollment":529},{"nctId":"NCT05396014","phase":"PHASE4","title":"The BEST Trial: Biomarkers for Evaluating Spine Treatments","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2022-09-12","conditions":"Chronic Low-back Pain","enrollment":1014},{"nctId":"NCT05430334","phase":"NA","title":"Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency","status":"COMPLETED","sponsor":"American University of Beirut Medical Center","startDate":"2022-07-13","conditions":"Nicotine Vaping, Nicotine Dependence, Nicotine Addiction","enrollment":130},{"nctId":"NCT05154669","phase":"PHASE3","title":"Integrating Financial Coaching and Smoking Cessation Coaching","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2022-12-08","conditions":"Smoking","enrollment":488},{"nctId":"NCT05683821","phase":"NA","title":"BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2023-07-24","conditions":"Quitting Smoking, Smoking Cessation, Smoking, Cigarette","enrollment":12376},{"nctId":"NCT06598397","phase":"PHASE4","title":"Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care","status":"RECRUITING","sponsor":"New York University","startDate":"2024-10-18","conditions":"Human Immunodeficiency Virus (HIV), Smoking Cessation","enrollment":500},{"nctId":"NCT06448351","phase":"NA","title":"Manipulating E-Cigarette Nicotine to Promote Public Health","status":"RECRUITING","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2024-05-20","conditions":"Tobacco-Related Carcinoma","enrollment":350},{"nctId":"NCT06931054","phase":"NA","title":"Combination of Acupuncture, Auricular Acupressure and Nicotine Replacement Therapy for Smoking Cessation","status":"RECRUITING","sponsor":"The University of Hong Kong","startDate":"2025-05-05","conditions":"Smoking","enrollment":270},{"nctId":"NCT04969198","phase":"PHASE2","title":"UW Withdraw From Tobacco Study","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2021-07-13","conditions":"Tobacco Dependence","enrollment":232},{"nctId":"NCT00943618","phase":"PHASE3","title":"Combining Varenicline and Bupropion for Smoking Cessation","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2010-05-17","conditions":"Smoking Cessation","enrollment":641},{"nctId":"NCT05257629","phase":"PHASE3","title":"Aggressive Smoking Cessation Trial (ASAP)","status":"RECRUITING","sponsor":"Sir Mortimer B. Davis - Jewish General Hospital","startDate":"2023-02-02","conditions":"Acute Coronary Syndrome, Cardiovascular Diseases","enrollment":798},{"nctId":"NCT05665465","phase":"EARLY_PHASE1","title":"Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking","status":"RECRUITING","sponsor":"Duke University","startDate":"2024-01-19","conditions":"Adverse Childhood Experiences, Nicotine Dependence, Cigarettes","enrollment":150},{"nctId":"NCT03720899","phase":"PHASE2, PHASE3","title":"Comparing NicoBloc to Nicotine Lozenges","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2019-03-21","conditions":"Smoking Cessation, Nicotine Dependence","enrollment":45},{"nctId":"NCT04332926","phase":"NA","title":"Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)","status":"COMPLETED","sponsor":"Virginia Commonwealth University","startDate":"2021-01-05","conditions":"Electronic Cigarette Use","enrollment":44},{"nctId":"NCT06691386","phase":"NA","title":"Nicotine Pharmacokinetics and Subjective Effects of Oral Nicotine Products Relative to Smokeless Tobacco in Adult Users","status":"COMPLETED","sponsor":"Altria Client Services LLC","startDate":"2023-02-06","conditions":"Tobacco Use","enrollment":64},{"nctId":"NCT01959607","phase":"NA","title":"Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 (THS 2.2)","status":"COMPLETED","sponsor":"Philip Morris Products S.A.","startDate":"2013-07","conditions":"Smoking","enrollment":65},{"nctId":"NCT04170907","phase":"NA","title":"Pharmacokinetics and Pharmacodynamics of Different Nicotine Salt Concentration Vape System Pods and Free-base Nicotine","status":"COMPLETED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2022-04-19","conditions":"Nicotine Dependence","enrollment":20},{"nctId":"NCT06350175","phase":"PHASE4","title":"Emergency Department Management of Tobacco Use Disorder","status":"WITHDRAWN","sponsor":"West Virginia University","startDate":"2024-08","conditions":"Tobacco Use Disorder, Tobacco Use Cessation","enrollment":""},{"nctId":"NCT05275725","phase":"PHASE1","title":"Finding Solutions to Thrive After Birth Asphyxia in Africa","status":"ACTIVE_NOT_RECRUITING","sponsor":"Pia Wintermark","startDate":"2022-07-01","conditions":"Birth Asphyxia","enrollment":18},{"nctId":"NCT04045964","phase":"PHASE4","title":"Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2017-10-29","conditions":"Environmental Tobacco Smoke, Smoking Cessation","enrollment":32},{"nctId":"NCT05664672","phase":"NA","title":"Study to Evaluate Changes in Smokers Using on!® Nicotine Pouches","status":"COMPLETED","sponsor":"Altria Client Services LLC","startDate":"2021-05-11","conditions":"Tobacco Use","enrollment":149},{"nctId":"NCT05136690","phase":"PHASE1","title":"Evoked Responses as Pharmacodynamic Biomarkers in Healthy and Schizophrenic Participants (MK-4334-007)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2022-04-27","conditions":"Cognitive Impairment Associated With Schizophrenia","enrollment":38},{"nctId":"NCT03611881","phase":"PHASE4","title":"Assessing the Integration of Tobacco Cessation Treatment Into Lung Cancer Screening (LCS)","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2019-04-01","conditions":"Smoking, Tobacco","enrollment":642},{"nctId":"NCT03384784","phase":"PHASE2","title":"Effect of Galantamine on Inflammation and Cognition","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2017-10-30","conditions":"HIV Associated Cognitive Motor Complex","enrollment":63},{"nctId":"NCT05280769","phase":"NA","title":"Effects of an Oral Nicotine Product in Smokeless Tobacco Users","status":"COMPLETED","sponsor":"Virginia Commonwealth University","startDate":"2022-08-23","conditions":"Tobacco Use","enrollment":31},{"nctId":"NCT04535362","phase":"EARLY_PHASE1","title":"Nicotine's Potential Abuse With Menthol","status":"COMPLETED","sponsor":"Yale University","startDate":"2021-06-28","conditions":"Nicotine Dependence","enrollment":16},{"nctId":"NCT06171490","phase":"NA","title":"Pharmacokinetics and Comparative Bioavailability of Nicotine From Two Variants of NP2, NP2-4mg and NP2-6mg, Compared to Nicotine Lozenge 4mg (Loz-4mg) and Nicotine Gum 4mg (Gum-4mg)","status":"COMPLETED","sponsor":"Philip Morris Products S.A.","startDate":"2023-10-20","conditions":"Tobacco Use","enrollment":56},{"nctId":"NCT04038515","phase":"PHASE2","title":"Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes","status":"COMPLETED","sponsor":"Yale University","startDate":"2022-10-27","conditions":"Nicotine, E-liquid Flavors","enrollment":54},{"nctId":"NCT03538938","phase":"PHASE4","title":"Improving Quitline Support Study","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2018-06-07","conditions":"Tobacco Use Cessation","enrollment":1316},{"nctId":"NCT05290025","phase":"NA","title":"Easy Access to Smoking Cessation for People Receiving Opioid Agonist Therapy Who Are Smoking Tobacco","status":"ACTIVE_NOT_RECRUITING","sponsor":"Haukeland University Hospital","startDate":"2022-04-07","conditions":"Smoking Cessation, Substance-Related Disorders","enrollment":266},{"nctId":"NCT05627596","phase":"PHASE2","title":"Free Samples for Health","status":"ENROLLING_BY_INVITATION","sponsor":"Hennepin Healthcare Research Institute","startDate":"2023-06-12","conditions":"Cigarette Smoking","enrollment":1200},{"nctId":"NCT03169101","phase":"","title":"Cognition and Smoking Relapse (HCS)","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2016-07-01","conditions":"Smoking Cessation","enrollment":274},{"nctId":"NCT04384562","phase":"NA","title":"Studying the Role of Brain Molecules for Decision Making","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2020-12-17","conditions":"Decision Making, Healthy","enrollment":160},{"nctId":"NCT04602494","phase":"PHASE4","title":"Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents","status":"TERMINATED","sponsor":"Massachusetts General Hospital","startDate":"2020-12-18","conditions":"Vaping, Nicotine Dependence","enrollment":5},{"nctId":"NCT06063421","phase":"NA","title":"Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan","status":"NOT_YET_RECRUITING","sponsor":"Strategic Health Research Limited","startDate":"2024-06-01","conditions":"Smoking Cessation, Electronic Cigarette Use","enrollment":438},{"nctId":"NCT05024747","phase":"PHASE1","title":"A Bioequivalence Study of 21 Milligram (mg) Nicotine Transdermal Patches (NicoDerm CQ, GlaxoSmithKline [GSK] Dungarvan) Compared to the Current Marketed 21 mg Nicotine Transdermal Patches (NicoDerm CQ, Alza) in Healthy Adult Smokers","status":"COMPLETED","sponsor":"HALEON","startDate":"2021-09-01","conditions":"Tobacco Use Disorder","enrollment":22},{"nctId":"NCT01935713","phase":"NA","title":"Preliminary Investigation of Novel Methods to Reduce Children's Secondhand Smoke Exposure","status":"COMPLETED","sponsor":"University of Oklahoma","startDate":"2012-04","conditions":"Secondhand Smoke","enrollment":89},{"nctId":"NCT04591743","phase":"NA","title":"Effectiveness of Transcranial Magnetic Stimulation (TMS) in Smoking Cessation, Combining Withdrawal Stimulation Followed by Maintenance Stimulation to Prevent Relapse.","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2020-06-29","conditions":"Smoking Cessation","enrollment":79},{"nctId":"NCT00727103","phase":"PHASE4","title":"Varenicline Treatment in Alcohol and Nicotine Dependent Patients With Schizophrenia","status":"COMPLETED","sponsor":"State University of New York - Upstate Medical University","startDate":"2008-07","conditions":"Schizophrenia, Schizoaffective Disorder, Alcohol Dependence","enrollment":10},{"nctId":"NCT03000387","phase":"PHASE4","title":"Personalized Dosing of Nicotine Replacement (NRT to Effect)","status":"COMPLETED","sponsor":"Centre for Addiction and Mental Health","startDate":"2018-01-23","conditions":"Tobacco Use Disorder, Nicotine Dependence","enrollment":211},{"nctId":"NCT01589081","phase":"NA","title":"Effects of Progesterone on IV Nicotine-Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effect","status":"WITHDRAWN","sponsor":"Mclean Hospital","startDate":"2008-09","conditions":"Nicotine Dependence","enrollment":""},{"nctId":"NCT01589068","phase":"NA","title":"Effects of Progesterone on IV Nicotine Induced Changes on BOLD fMRI Signal, Hormones and Subjective Ratings of Stimulant Drugs","status":"WITHDRAWN","sponsor":"Mclean Hospital","startDate":"2007-01","conditions":"Nicotine Dependence","enrollment":""},{"nctId":"NCT06170138","phase":"NA","title":"Study to Assess PK, PD, Nicotine Extraction, Palatability, Subjective Effects of Nicotine Pouches - Daily Nicotine Users","status":"UNKNOWN","sponsor":"Amplicon AB","startDate":"2023-11-24","conditions":"Nicotine Use Disorder","enrollment":12},{"nctId":"NCT05159934","phase":"PHASE1","title":"Nicotine Differences in Smokers","status":"COMPLETED","sponsor":"Yale University","startDate":"2022-02-16","conditions":"Nicotine Dependence","enrollment":11},{"nctId":"NCT04286295","phase":"NA","title":"Cytisine Compared to Combination NRT in Relapsed Smokers","status":"TERMINATED","sponsor":"Ottawa Heart Institute Research Corporation","startDate":"2022-03-14","conditions":"Smoking Cessation, Coronary Artery Disease","enrollment":13},{"nctId":"NCT05157672","phase":"EARLY_PHASE1","title":"Evaluating the Pharmacokinetics and Drug Interaction Potential of the Botanical Dietary Supplement Cinnamon","status":"UNKNOWN","sponsor":"Washington State University","startDate":"2021-12-14","conditions":"Interaction Drug Food","enrollment":16},{"nctId":"NCT04433767","phase":"PHASE2","title":"Depressed Mood Improvement Through Nicotine Dosing 2","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2020-12-15","conditions":"Depressive Disorder","enrollment":29},{"nctId":"NCT05825924","phase":"PHASE3","title":"Effectiveness of Different THR Products in Adult Population","status":"UNKNOWN","sponsor":"Foundation for a Smoke Free World INC","startDate":"2024-06","conditions":"Smoking Cessation","enrollment":258},{"nctId":"NCT04468230","phase":"PHASE2","title":"Study of Nicotine for Pain Associated With Chemotherapy-Induced Peripheral Neuropathy","status":"TERMINATED","sponsor":"Virginia Commonwealth University","startDate":"2020-07-31","conditions":"Neuropathy, Peripheral Neuropathy, Neuropathic Pain","enrollment":4},{"nctId":"NCT00888459","phase":"PHASE2","title":"A Pilot Study Evaluating Nicotine Lozenges and Self Help","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2008-04","conditions":"Smokeless Tobacco Use","enrollment":60},{"nctId":"NCT04891406","phase":"NA","title":"A Randomised, Cross-over, Relative Bioavailability Study of Nicotine Delivery and Nicotine Extraction From Oral Products","status":"COMPLETED","sponsor":"Imperial Brands PLC","startDate":"2020-07-01","conditions":"Healthy Volunteers","enrollment":24},{"nctId":"NCT05060965","phase":"EARLY_PHASE1","title":"Inpatient Smoking Cessation Pilot Program","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2019-10-01","conditions":"Tobacco Use Cessation","enrollment":""},{"nctId":"NCT04717544","phase":"NA","title":"Embedding Comprehensive Smoking Cessation Programs Into Community Clinics","status":"COMPLETED","sponsor":"Friends Research Institute, Inc.","startDate":"2019-10-01","conditions":"Smoking Cessation","enrollment":406},{"nctId":"NCT02157610","phase":"NA","title":"Smoking Cessation for Cervical Cancer Survivors","status":"COMPLETED","sponsor":"H. Lee Moffitt Cancer Center and Research Institute","startDate":"2015-01","conditions":"Cervical Cancer, Tobacco Use, Smoking Cessation","enrollment":202},{"nctId":"NCT04011280","phase":"PHASE4","title":"Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2019-08-12","conditions":"Bipolar Disorder, Schizophrenia, Schizoaffective Disorder","enrollment":39},{"nctId":"NCT04084210","phase":"PHASE2","title":"Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2020-09-09","conditions":"Nicotine Dependence","enrollment":209},{"nctId":"NCT00775749","phase":"NA","title":"Transdermal Nicotine in Female Patients at High Risk for Post Operative Nausea and/or Vomiting (PONV)","status":"WITHDRAWN","sponsor":"Ochsner Health System","startDate":"2009-04","conditions":"Postoperative Nausea and Vomiting","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Nicotine (2 mg)","genericName":"Nicotine (2 mg)","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nicotine (2 mg) is used in various interventions, including NRT Gum, to treat conditions such as smoking cessation and nicotine dependence. It is also studied in relation to smoking, vaping, and e-cig use, with its pharmacokinetic profile and safety evaluated in clinical trials like NCT01959607.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}