{"id":"nicotinamide-treatment","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hepatotoxicity (at high doses)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nicotinamide (vitamin B3) is a precursor to nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in energy production, DNA repair, and cellular stress responses. By increasing intracellular NAD+ levels, nicotinamide treatment may enhance mitochondrial function and activate sirtuins and PARPs, proteins involved in genomic stability and cellular resilience. This mechanism has been explored in conditions characterized by impaired cellular energy metabolism or DNA damage.","oneSentence":"Nicotinamide replenishes NAD+ cofactor pools to support cellular energy metabolism and DNA repair pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:23:08.443Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Phase 3 indication not publicly specified; likely dermatologic or metabolic condition based on nicotinamide's known clinical applications"}]},"trialDetails":[{"nctId":"NCT01303341","phase":"PHASE1","title":"Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2011-02-18","conditions":"Advanced Malignant Solid Neoplasm, Recurrent Melanoma, Refractory Malignant Solid Neoplasm","enrollment":35},{"nctId":"NCT06044935","phase":"NA","title":"Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate","status":"RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2024-01-08","conditions":"Overweight, Obesity","enrollment":100},{"nctId":"NCT01861314","phase":"PHASE1","title":"Bortezomib, Sorafenib Tosylate, and Decitabine in Treating Patients With Acute Myeloid Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2013-07-03","conditions":"Acute Myeloid Leukemia, Acute Myeloid Leukemia Post Cytotoxic Therapy, Recurrent Adult Acute Myeloid Leukemia","enrollment":15},{"nctId":"NCT07463651","phase":"PHASE3","title":"MRD-guided Maintenance Post-HCT: Gilteritini vs Sorafenib","status":"RECRUITING","sponsor":"The First Affiliated Hospital of Soochow University","startDate":"2026-05-01","conditions":"Acute Myeloid Leukemia (AML), FLT3-ITD Mutation, Allogeneic Hematopoietic Cell Transplantation (HCT)","enrollment":594},{"nctId":"NCT03298451","phase":"PHASE3","title":"Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"AstraZeneca","startDate":"2017-10-11","conditions":"Hepatocellular Carcinoma","enrollment":1324},{"nctId":"NCT06309485","phase":"PHASE2","title":"Phase 2 Study of WGI-0301 for Advanced HCC","status":"RECRUITING","sponsor":"Zhejiang Haichang Biotech Co., Ltd.","startDate":"2024-07-31","conditions":"Advanced Hepatocellular Carcinoma (HCC)","enrollment":60},{"nctId":"NCT04720716","phase":"PHASE3","title":"A Study to Compare the Effectiveness and Safety of IBI310 Combined With Sintilimab Versus Sorafenib in the First-line Treatment of Advanced HCC","status":"COMPLETED","sponsor":"Innovent Biologics (Suzhou) Co. Ltd.","startDate":"2021-02-07","conditions":"Hepatocellular Carcinoma","enrollment":344},{"nctId":"NCT07475546","phase":"PHASE3","title":"Combination Gerotherapeutic Interventions for Healthspan Improvement","status":"ACTIVE_NOT_RECRUITING","sponsor":"AgelessRx","startDate":"2025-07-23","conditions":"Healthspan Improvement, Aging, Longevity","enrollment":30},{"nctId":"NCT05468359","phase":"PHASE1, PHASE2","title":"Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients","status":"RECRUITING","sponsor":"St. Jude Children's Research Hospital","startDate":"2022-11-07","conditions":"Refractory Solid Tumor, Hepatocellular Carcinoma, Malignant Solid Tumor","enrollment":64},{"nctId":"NCT06579209","phase":"NA","title":"NAD+ Oral Supplement Pilot Intervention in Adult Females","status":"COMPLETED","sponsor":"University of Rhode Island","startDate":"2024-12-01","conditions":"Cognitive Change, Inflammation, Neurodegenerative Diseases","enrollment":53},{"nctId":"NCT07468175","phase":"NA","title":"A 16-week Clinical Study Investigating a Dark Spot Corrector Serum in Women With Moderate Discrete Hyperpigmentation","status":"COMPLETED","sponsor":"Revision Skincare","startDate":"2024-10-21","conditions":"Hyperpigmentation, Dark Spots","enrollment":48},{"nctId":"NCT04571008","phase":"NA","title":"Effect of NMN Supplementation on Organ System Biology","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2020-10-01","conditions":"Glucose Metabolism Disorders","enrollment":56},{"nctId":"NCT06760533","phase":"EARLY_PHASE1","title":"Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)","status":"NOT_YET_RECRUITING","sponsor":"NYU Langone Health","startDate":"2026-08","conditions":"IBS - Irritable Bowel Syndrome","enrollment":10},{"nctId":"NCT06582706","phase":"PHASE1, PHASE2","title":"Nicotinic Acid for the Treatment of Alzheimer's Disease","status":"RECRUITING","sponsor":"Indiana University","startDate":"2024-12-19","conditions":"Alzheimer Disease","enrollment":30},{"nctId":"NCT06200155","phase":"PHASE2","title":"Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2024-04-16","conditions":"Depression, Anxiety, Psilocybin-Assisted Psychotherapy, Advanced Cancer","enrollment":30},{"nctId":"NCT02185560","phase":"","title":"Prospective, Non-interventional, Post-authorization Safety Study That Includes All Patients Diagnosed as Unresectable Differentiated Thyroid Carcinoma and Treated With Sorafenib","status":"ACTIVE_NOT_RECRUITING","sponsor":"Bayer","startDate":"2014-06-27","conditions":"Thyroid Carcinoma","enrollment":453},{"nctId":"NCT02184416","phase":"","title":"Study Of The Impact Of Inlyta In 2nd Line On The Treatment Outcomes Of mRCC Patients Treated With Sutent In 1st Line In The Real Life Setting","status":"COMPLETED","sponsor":"Pfizer","startDate":"2014-10-31","conditions":"Metastatic Renal Cell Carcinoma (mRCC)","enrollment":554},{"nctId":"NCT01946529","phase":"PHASE2","title":"Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Jude Children's Research Hospital","startDate":"2013-12-27","conditions":"Desmoplastic Small Round Cell Tumor, Ewing Sarcoma of Bone or Soft Tissue, Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor","enrollment":24},{"nctId":"NCT02559778","phase":"PHASE2","title":"Pediatric Precision Laboratory Advanced Neuroblastoma Therapy","status":"RECRUITING","sponsor":"Giselle Sholler","startDate":"2015-09","conditions":"Neuroblastoma","enrollment":500},{"nctId":"NCT07286318","phase":"EARLY_PHASE1","title":"A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients","status":"NOT_YET_RECRUITING","sponsor":"Marissa Lobl","startDate":"2026-03-01","conditions":"Skin Cancer, Cutaneous Squamous Cell Carcinoma (CSCC), Actinic Keratosis (AK)","enrollment":20},{"nctId":"NCT04039607","phase":"PHASE3","title":"A Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Hepatocellular Carcinoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Bristol-Myers Squibb","startDate":"2019-09-30","conditions":"Hepatocellular Carcinoma","enrollment":732},{"nctId":"NCT07414212","phase":"PHASE1, PHASE2","title":"Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS)","status":"RECRUITING","sponsor":"Biogipuzkoa Health Research Institute","startDate":"2025-11-25","conditions":"Amyotrophic Lateral Sclerosis","enrollment":90},{"nctId":"NCT04770896","phase":"PHASE3","title":"A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hoffmann-La Roche","startDate":"2021-04-26","conditions":"Unresectable Hepatocellular Carcinoma","enrollment":557},{"nctId":"NCT06227221","phase":"PHASE2","title":"Efficacy and Safety of Sorafenib in New-Onset Type 1 Diabetes Mellitus","status":"NOT_YET_RECRUITING","sponsor":"Second Xiangya Hospital of Central South University","startDate":"2026-02","conditions":"Type 1 Diabetes","enrollment":10},{"nctId":"NCT02143726","phase":"PHASE2","title":"Sorafenib Tosylate With or Without Everolimus in Treating Patients With Advanced, Radioactive Iodine Refractory Hurthle Cell Thyroid Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Alliance for Clinical Trials in Oncology","startDate":"2014-10-09","conditions":"Refractory Hurthle Cell Thyroid Cancer","enrollment":35},{"nctId":"NCT05934409","phase":"NA","title":"Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery","status":"RECRUITING","sponsor":"Université de Sherbrooke","startDate":"2023-11-01","conditions":"Diabetes Mellitus Type 2","enrollment":40},{"nctId":"NCT06843148","phase":"NA","title":"Stimulating Fat Tissue Storage With Niacin to Reduce Fat Accumulation in the Liver.","status":"RECRUITING","sponsor":"Université de Sherbrooke","startDate":"2026-04","conditions":"Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Liver Fibrosis/NASH, Non-Alcoholic Steato-Hepatitis (NASH)","enrollment":36},{"nctId":"NCT01903694","phase":"PHASE3","title":"Randomized Trial Sorafenib-Pravastatin Versus Sorafenib Alone for the Palliative Treatment of Child-Pugh A Hepatocellular Carcinoma","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2010-03","conditions":"Child-Pugh A Hepatocellular Carcinoma","enrollment":474},{"nctId":"NCT01275300","phase":"NA","title":"Biosynthesis of PGD2 in Vivo","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2007-07","conditions":"Hyperlipidemia","enrollment":9},{"nctId":"NCT00989469","phase":"PHASE1, PHASE2","title":"Sorafenib With Irinotecan in Metastatic Colorectal Cancer (mCRC) and K-RAS Mutation","status":"COMPLETED","sponsor":"Institut du Cancer de Montpellier - Val d'Aurelle","startDate":"2009-02","conditions":"Metastatic Colorectal Cancer","enrollment":64},{"nctId":"NCT03211416","phase":"PHASE1, PHASE2","title":"Sorafenib Tosylate and Pembrolizumab in Treating Patients With Advanced or Metastatic Liver Cancer","status":"COMPLETED","sponsor":"Roswell Park Cancer Institute","startDate":"2017-12-07","conditions":"Advanced Adult Hepatocellular Carcinoma, Child-Pugh Class A, Stage III Hepatocellular Carcinoma","enrollment":37},{"nctId":"NCT06018467","phase":"PHASE2","title":"Senolytics to Improve Osteoporosis Therapy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Odense University Hospital","startDate":"2023-09-06","conditions":"Osteopenia, Osteoporosis, Age-related Bone Loss","enrollment":120},{"nctId":"NCT01730937","phase":"PHASE3","title":"Sorafenib Tosylate With or Without Stereotactic Body Radiation Therapy in Treating Patients With Liver Cancer","status":"COMPLETED","sponsor":"Radiation Therapy Oncology Group","startDate":"2013-04","conditions":"Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer","enrollment":193},{"nctId":"NCT03164057","phase":"PHASE2","title":"A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Jude Children's Research Hospital","startDate":"2017-06-15","conditions":"Acute Myeloid Leukemia, Myelodysplastic Syndromes","enrollment":206},{"nctId":"NCT04914845","phase":"PHASE1","title":"KPT-9274 in Patients With Relapsed and Refractory Acute Myeloid Leukemia","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2021-08-27","conditions":"Acute Myeloid Leukemia, Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory","enrollment":16},{"nctId":"NCT05590468","phase":"PHASE2","title":"A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ralitza Gavrilova","startDate":"2023-05-26","conditions":"Mitochondrial Myopathy","enrollment":34},{"nctId":"NCT05878119","phase":"PHASE2","title":"Effects of MIB-626 With and Without A High-Intensity Multi-Dimensional Exercise Training Program","status":"COMPLETED","sponsor":"Metro International Biotech, LLC","startDate":"2023-10-25","conditions":"Healthy","enrollment":124},{"nctId":"NCT00826540","phase":"PHASE2","title":"Sorafenib and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer","status":"COMPLETED","sponsor":"Alliance for Clinical Trials in Oncology","startDate":"2009-09","conditions":"Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV Colon Cancer","enrollment":83},{"nctId":"NCT05561738","phase":"NA","title":"Nicotinamide Riboside in Ulcerative Colitis","status":"RECRUITING","sponsor":"University of Pittsburgh","startDate":"2024-02-28","conditions":"Ulcerative Colitis","enrollment":40},{"nctId":"NCT07341217","phase":"NA","title":"Chemo Brain Prehab Project","status":"NOT_YET_RECRUITING","sponsor":"Dr. Chris Gaffney","startDate":"2026-01-30","conditions":"Colorectal Cancer, Older Adults (60 - 85 Years Old), Physically Inactive","enrollment":86},{"nctId":"NCT07337486","phase":"NA","title":"\"Evaluation of a Non-Pharmacological Skin Care Intervention for the Prevention and Treatment of Skin Toxicities Caused by Immunotherapy in Cancer Patients\"","status":"COMPLETED","sponsor":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","startDate":"2022-05-30","conditions":"Skin Toxicity in Patients on Checkpoint Inhibitors","enrollment":130},{"nctId":"NCT05224336","phase":"PHASE1","title":"Psilocybin-assisted Therapy for Phantom Limb Pain","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2022-10-03","conditions":"Phantom Limb Pain","enrollment":10},{"nctId":"NCT03685253","phase":"PHASE1, PHASE2","title":"Nicotinamide Riboside for Diabetic Neuropathy","status":"TERMINATED","sponsor":"University of Maryland, Baltimore","startDate":"2019-01-24","conditions":"Diabetic Neuropathy Peripheral","enrollment":10},{"nctId":"NCT04677049","phase":"PHASE1, PHASE2","title":"Study of Niacin in Glioblastoma","status":"SUSPENDED","sponsor":"AHS Cancer Control Alberta","startDate":"2021-03-18","conditions":"Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype","enrollment":59},{"nctId":"NCT05117957","phase":"PHASE2","title":"Efficacy and Safety of Sorafenib in Previously Treated Advanced Hepatocellular Carcinoma: SOPT Study","status":"COMPLETED","sponsor":"Bo Hyun Kim","startDate":"2022-03-08","conditions":"Advanced Hepatocellular Carcinoma","enrollment":50},{"nctId":"NCT07306364","phase":"PHASE2","title":"Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain","status":"NOT_YET_RECRUITING","sponsor":"Yale University","startDate":"2026-06","conditions":"Chronic Low Back Pain (CLBP), Physical Therapy, Psilocybin","enrollment":45},{"nctId":"NCT07022938","phase":"PHASE4","title":"Nutritional Supplement for Treating Chemotherapy Induced Neuropathy","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2021-11-01","conditions":"Cancer, Neuropathy, Chemotherapy Induced Pain Neuropathy","enrollment":71},{"nctId":"NCT01658878","phase":"PHASE1, PHASE2","title":"An Immuno-therapy Study to Evaluate the Effectiveness, Safety and Tolerability of Nivolumab or Nivolumab in Combination With Other Agents in Patients With Advanced Liver Cancer","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"2012-10-30","conditions":"Hepatocellular Carcinoma","enrollment":657},{"nctId":"NCT03533582","phase":"PHASE3","title":"Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's Oncology Group","startDate":"2018-05-24","conditions":"Childhood Hepatocellular Carcinoma, Childhood Malignant Liver Neoplasm, Fibrolamellar Carcinoma","enrollment":537},{"nctId":"NCT07280637","phase":"NA","title":"Regenarative Treatment of Periocular Wrinkles With PDRN","status":"RECRUITING","sponsor":"University of Taubate","startDate":"2025-11-30","conditions":"Skin Wrinklings","enrollment":25},{"nctId":"NCT07258667","phase":"PHASE1","title":"Pilot Study of the Efficacy of Nicotinamide (Vitamin B3) in Leber's Hereditary Optic Neuropathy","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Angers","startDate":"2026-04","conditions":"Leber Hereditary Optic Neuropathy (LHON), Leber's Hereditary Optic Neuropathy (LHON), Mitochondrial Disease","enrollment":13},{"nctId":"NCT00494182","phase":"PHASE2","title":"Sorafenib in Combination With Carboplatin and Paclitaxel in Treating Participants With Metastatic or Recurrent Head and Neck Squamous Cell Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2007-04-25","conditions":"Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Squamous Cell Carcinoma of the Hypopharynx, Metastatic Squamous Cell Carcinoma of the Larynx","enrollment":48},{"nctId":"NCT01871766","phase":"PHASE2","title":"Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Jude Children's Research Hospital","startDate":"2013-12-04","conditions":"Rhabdomyosarcoma","enrollment":115},{"nctId":"NCT04120766","phase":"PHASE2","title":"Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging","status":"ACTIVE_NOT_RECRUITING","sponsor":"Gregory Jicha, MD, PhD","startDate":"2021-12-01","conditions":"Dementia, Mild Cognitive Impairment","enrollment":64},{"nctId":"NCT03247088","phase":"PHASE1, PHASE2","title":"Sorafenib, Busulfan and Fludarabine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2017-07-30","conditions":"Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia","enrollment":74},{"nctId":"NCT03755791","phase":"PHASE3","title":"Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Exelixis","startDate":"2018-06-10","conditions":"Hepatocellular Carcinoma","enrollment":837},{"nctId":"NCT07268339","phase":"PHASE3","title":"A Phase III Randomised Control Clinical Trial of Radiotherapy With Radiosensitisation Versus Intravesical Bacillus Calmette-Guerin Therapy for High-risk Non-muscle Invasive Bladder Cancer.","status":"NOT_YET_RECRUITING","sponsor":"The Christie NHS Foundation Trust","startDate":"2025-12-01","conditions":"High-Risk Non-Muscle Invasive Bladder Cancer","enrollment":328},{"nctId":"NCT07264010","phase":"PHASE2, PHASE3","title":"Sorafenib Combined With Venetoclax as Pre-emptive Therapy Strategy for MRD+ AML: a Prospective, Single-arm, Multicenter Clinical Study","status":"NOT_YET_RECRUITING","sponsor":"Nanfang Hospital, Southern Medical University","startDate":"2025-12-01","conditions":"Acute Myeloid Leukaemia (AML), Measurable Residual Disease (MRD)","enrollment":87},{"nctId":"NCT05398484","phase":"PHASE2, PHASE3","title":"Psilocybin Therapy in Advanced Cancer","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2023-05-24","conditions":"Advanced Cancer","enrollment":200},{"nctId":"NCT04844528","phase":"PHASE2","title":"Effects of Nicotinamide in Patients With Chronic Lymphocytic Leukemia With History of Non-melanoma Skin Cancers","status":"RECRUITING","sponsor":"University of Utah","startDate":"2022-02-25","conditions":"Chronic Lymphocytic Leukemia, Non-melanoma Skin Cancer (NMSC)","enrollment":86},{"nctId":"NCT04004000","phase":"PHASE2","title":"Evaluation of Safety, Tolerability, and Changes in Biomarker and Clinical Outcome Assessments of Losmapimod for FSHD1 With Extension","status":"TERMINATED","sponsor":"Fulcrum Therapeutics","startDate":"2019-08-23","conditions":"Facioscapulohumeral Muscular Dystrophy 1","enrollment":14},{"nctId":"NCT07251608","phase":"PHASE1","title":"Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus","status":"RECRUITING","sponsor":"ChromaDex, Inc.","startDate":"2025-10-01","conditions":"Healthy Volunteer, Fatigue","enrollment":40},{"nctId":"NCT01371981","phase":"PHASE3","title":"Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2011-06-20","conditions":"Acute Myeloid Leukemia, Leukemia Cutis, Myeloid Neoplasm","enrollment":1645},{"nctId":"NCT05947383","phase":"PHASE2","title":"Two Doses of Psilocybin for the Treatment of MDD in Adults With Cancer","status":"RECRUITING","sponsor":"Sunstone Medical","startDate":"2023-10-23","conditions":"Cancer, Major Depressive Disorder","enrollment":56},{"nctId":"NCT05846373","phase":"PHASE2","title":"Effect of Nicotinic Acid as Add on Therapy in Patients Receiving β Blocker for Prophylaxis of Moderate to Severe Migraine","status":"COMPLETED","sponsor":"Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","startDate":"2022-11-25","conditions":"Migraine Prophylaxis","enrollment":58},{"nctId":"NCT06599918","phase":"PHASE2","title":"Study of the Efficacy and Safety of Nicotinamide in Patients With Liver Fibrosis (NICOFIB)","status":"RECRUITING","sponsor":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","startDate":"2024-04-23","conditions":"Fatty Liver, Obesity, Hepatic Fibrosis","enrollment":30},{"nctId":"NCT04234217","phase":"NA","title":"Mechanisms of Prediabetic States in Sleep Apnea","status":"RECRUITING","sponsor":"University of Chicago","startDate":"2019-11-26","conditions":"Sleep Apnea, Pre-diabetes","enrollment":300},{"nctId":"NCT05397470","phase":"PHASE3","title":"Efficacy and Safety of Losmapimod in Treating Participants With Facioscapulohumeral Muscular Dystrophy (FSHD) (REACH)","status":"TERMINATED","sponsor":"Fulcrum Therapeutics","startDate":"2022-06-16","conditions":"Facioscapulohumeral Muscular Dystrophy (FSHD)","enrollment":260},{"nctId":"NCT06567717","phase":"PHASE2","title":"Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis","status":"RECRUITING","sponsor":"Cedars-Sinai Medical Center","startDate":"2025-11-03","conditions":"Idiopathic Pulmonary Fibrosis","enrollment":60},{"nctId":"NCT03132454","phase":"PHASE1","title":"Palbociclib and Sorafenib, Decitabine, or Dexamethasone in Treating Patients With Recurrent or Refractory Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2017-07-25","conditions":"Recurrent Acute Lymphoblastic Leukemia, Recurrent Acute Myeloid Leukemia, Refractory Acute Lymphoblastic Leukemia","enrollment":32},{"nctId":"NCT01187199","phase":"PHASE1","title":"Phase I Trial of Bevacizumab and Temsirolimus in Combination With 1) Carboplatin, 2) Paclitaxel, 3) Sorafenib for the Treatment of Advanced Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2010-08-19","conditions":"Advanced Cancer","enrollment":278},{"nctId":"NCT05033522","phase":"PHASE2, PHASE3","title":"Immunotherapy for Advanced Liver Cancer","status":"SUSPENDED","sponsor":"Mirror Biologics, Inc.","startDate":"2023-08-01","conditions":"Hepatocellular Carcinoma","enrollment":150},{"nctId":"NCT03412773","phase":"PHASE3","title":"A Study of Tislelizumab Versus Sorafenib in Participants With Unresectable Hepatocellular Carcinoma (HCC)","status":"COMPLETED","sponsor":"BeiGene","startDate":"2017-12-18","conditions":"Hepatocellular Carcinoma (HCC)","enrollment":684},{"nctId":"NCT06137833","phase":"NA","title":"Wide Spectrum Micronutrients Supplementation in Patients With Cancer Related Fatigue During Neoadjuvant and Adjuvant Chemotherapy","status":"RECRUITING","sponsor":"Pharmanutra S.p.a.","startDate":"2023-11-27","conditions":"Fatigue, Breast Cancer","enrollment":92},{"nctId":"NCT04264442","phase":"PHASE2","title":"Efficacy and Safety of Losmapimod in Treating Subjects With Facioscapulohumeral Muscular Dystrophy (FSHD) With Open-Label Extension (OLE)","status":"TERMINATED","sponsor":"Fulcrum Therapeutics","startDate":"2020-02-13","conditions":"Facioscapulohumeral Muscular Dystrophy (FSHD)","enrollment":76},{"nctId":"NCT05067998","phase":"","title":"The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature","status":"RECRUITING","sponsor":"Faith A. Richardson","startDate":"2025-12-21","conditions":"Anxiety Disorders and Symptoms, Fibromyalgia, Arthritis","enrollment":25},{"nctId":"NCT06333236","phase":"NA","title":"Effect of Kron (Citicoline and Nicotinamide Oral Solution) on Patients With Open-angle Glaucoma","status":"COMPLETED","sponsor":"ASST Santi Paolo e Carlo","startDate":"2025-04-10","conditions":"Glaucoma","enrollment":30},{"nctId":"NCT01475123","phase":"PHASE4","title":"Prospective Study of End Stage Renal Disease Patients With Coronary Artery Disease Treated by Oral Nicorandil","status":"ACTIVE_NOT_RECRUITING","sponsor":"Kumamoto University","startDate":"2008-06","conditions":"Coronary Artery Disease, End Stage Renal Disease","enrollment":268},{"nctId":"NCT07049068","phase":"PHASE1","title":"Comparison of Nicotinamide Treatments for Actinic Keratosis","status":"COMPLETED","sponsor":"Federal University of Rio Grande do Sul","startDate":"2022-02-01","conditions":"Actinic Keratoses","enrollment":74},{"nctId":"NCT06280482","phase":"PHASE1","title":"Nicotinamide Riboside (NR) to Treat Moyamoya-like Cerebrovascular Disease in Smooth Muscle Dysfunction Syndrome (SMDS)","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2024-03-06","conditions":"Smooth Muscle Dysfunction Syndrome (SMDS)","enrollment":15},{"nctId":"NCT03037437","phase":"PHASE2","title":"Sorafenib Induced Autophagy Using Hydroxychloroquine in Hepatocellular Cancer","status":"COMPLETED","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2017-02-16","conditions":"Hepatocellular Cancer","enrollment":64},{"nctId":"NCT07024966","phase":"NA","title":"Effect of the Combination of Pterostilbene Cocrystal With Silybin and Nicotinamide Riboside on Exercise-Induced Oxidative Stress","status":"RECRUITING","sponsor":"Fundació Eurecat","startDate":"2025-08-01","conditions":"Oxidative Stress, Physical Activity, Antioxidant Effect","enrollment":14},{"nctId":"NCT04589546","phase":"PHASE3","title":"Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?","status":"ACTIVE_NOT_RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2020-10-01","conditions":"Acute Kidney Injury, Septic Shock, Nicotinamide","enrollment":310},{"nctId":"NCT07138508","phase":"PHASE1, PHASE2","title":"Oral Nicorandil for Prevention of No Reflow Phenomenon in Anterior STEMI Patients Undergoing PPCI","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-03-10","conditions":"No Reflow Phenomenon, Anterior STEMI","enrollment":300},{"nctId":"NCT04959864","phase":"NA","title":"Efficacy Study of a Food Supplement With Myo-inositol, N-Acetyl-Cystein, Zinc and Vitamins on Sperm DNA Fragmentation","status":"RECRUITING","sponsor":"GYNOV","startDate":"2021-07-07","conditions":"Male Infertility","enrollment":72},{"nctId":"NCT00265798","phase":"PHASE2","title":"Sorafenib in Treating Patients With Malignant Gastrointestinal Stromal Tumor That Progressed During or After Previous Treatment With Imatinib Mesylate and Sunitinib Malate","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2005-09-14","conditions":"Gastrointestinal Stromal Tumor","enrollment":38},{"nctId":"NCT05935787","phase":"PHASE3","title":"Cytoflavin in the Complex Rehabilitation of Stroke Patients","status":"COMPLETED","sponsor":"POLYSAN Scientific & Technological Pharmaceutical Company","startDate":"2023-06-09","conditions":"Stroke","enrollment":240},{"nctId":"NCT05822752","phase":"PHASE2","title":"Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC)","status":"ACTIVE_NOT_RECRUITING","sponsor":"AbbVie","startDate":"2023-09-21","conditions":"Hepatocellular Carcinoma","enrollment":130},{"nctId":"NCT07121439","phase":"NA","title":"Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES","status":"NOT_YET_RECRUITING","sponsor":"Dr.dr.Irma Bernadette, SpKK (K)","startDate":"2025-09-15","conditions":"Melasma, Post-acne Hyperpigmentation","enrollment":68},{"nctId":"NCT07119996","phase":"PHASE1","title":"Clinical Trial on the Protective Role of Vitamin B3 in Enhancing Immunotherapy for Bladder Cancer Patients","status":"NOT_YET_RECRUITING","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","startDate":"2025-10-01","conditions":"Bladder (Urothelial, Transitional Cell) Cancer","enrollment":12},{"nctId":"NCT06805656","phase":"PHASE2","title":"Multi Interventional Approaches to Mitigate HIV Reservoirs Aiming the Sustained HIV Remission Without Antiretrovirals","status":"NOT_YET_RECRUITING","sponsor":"Federal University of São Paulo","startDate":"2025-09-01","conditions":"Hiv, HIV I Infection","enrollment":70},{"nctId":"NCT02029001","phase":"PHASE2","title":"Adapting Treatment to the Tumor Molecular Alterations for Patients With Advanced Solid Tumors: MyOwnSpecificTreatment","status":"RECRUITING","sponsor":"Centre Leon Berard","startDate":"2014-03","conditions":"Malignant Solid Neoplasms","enrollment":900},{"nctId":"NCT06776510","phase":"PHASE1, PHASE2","title":"A Clinical Study of NAD in the Treatment of Immune Thrombocytopenia","status":"RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2025-01-15","conditions":"Immune Thrombocytopenia, Treatment","enrollment":20},{"nctId":"NCT05452772","phase":"PHASE2","title":"5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2023-11-01","conditions":"Tobacco Use Disorder","enrollment":66},{"nctId":"NCT01141309","phase":"PHASE2","title":"Evaluating the Combination of Everolimus and Sorafenib in the Treatment of Thyroid Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2010-06","conditions":"Thyroid Cancer","enrollment":41},{"nctId":"NCT07062120","phase":"NA","title":"Efficacy and Safety of 30% Salicylic Acid and 10% Nicotinamide Combined Therapy in Melasma","status":"COMPLETED","sponsor":"Second Affiliated Hospital of Xi'an Jiaotong University","startDate":"2021-01-01","conditions":"Melasma","enrollment":56},{"nctId":"NCT04464070","phase":"EARLY_PHASE1","title":"Pathways of Eicosanoid Metabolism","status":"ENROLLING_BY_INVITATION","sponsor":"Vanderbilt University","startDate":"2020-08-15","conditions":"Metabolism of Prostaglandin D2","enrollment":10},{"nctId":"NCT07006194","phase":"NA","title":"Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)","status":"NOT_YET_RECRUITING","sponsor":"Università degli Studi 'G. d'Annunzio' Chieti e Pescara","startDate":"2025-10-01","conditions":"Glaucoma","enrollment":360},{"nctId":"NCT07004725","phase":"PHASE2","title":"Therapy of Niacin for Rheumatoid Arthritis","status":"NOT_YET_RECRUITING","sponsor":"Peking University People's Hospital","startDate":"2025-05-28","conditions":"Rheumatoid Arthritis (RA)","enrollment":60},{"nctId":"NCT04055818","phase":"PHASE1","title":"A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease","status":"RECRUITING","sponsor":"EpiDestiny, Inc.","startDate":"2020-01-24","conditions":"Sickle Cell Disease","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":159,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NICOBION"],"phase":"phase_3","status":"active","brandName":"Nicotinamide treatment","genericName":"Nicotinamide treatment","companyName":"Assistance Publique - Hôpitaux de Paris","companyId":"assistance-publique-h-pitaux-de-paris","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nicotinamide replenishes NAD+ cofactor pools to support cellular energy metabolism and DNA repair pathways. Used for Phase 3 indication not publicly specified; likely dermatologic or metabolic condition based on nicotinamide's known clinical applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}