{"id":"nicomorphine","rwe":[{"pmid":"38543161","year":"2024","title":"Small-Angle X-ray Scattering (SAXS) Used for the Identification of Nicomorphine Polymorphic Changes at the Early Stage to Avoid Varied Stability and Possible Side Effects.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"34528849","year":"2021","title":"Towards identifying nicomorphine administration in doping control: synthesis of metabolites.","finding":"","journal":"Bioanalysis","studyType":"Clinical Study"},{"pmid":"30153698","year":"2019","title":"Fast-Track Management in Off-Pump Coronary Artery Bypass Grafting: Dexmedetomidine Provides Rapid Extubation and Effective Pain Modulation.","finding":"","journal":"The Thoracic and cardiovascular surgeon","studyType":"Clinical Study"},{"pmid":"18585338","year":"2008","title":"A screening test for heroin based on sequential injection analysis with dual-reagent chemiluminescence detection.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"17072916","year":"2007","title":"In-hospital use of opioids increases rate of coded postoperative paralytic ileus.","finding":"","journal":"Pharmacoepidemiology and drug safety","studyType":"Clinical Study"}],"tags":[{"label":"Opioid Agonist","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N02AA04","category":"atc"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Opioid","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Narcotics","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":90.901,"date":"","count":21,"signal":"Macular degeneration","source":"DrugCentral FAERS","actionTaken":"Reported 21 times (LLR=91)"},{"llr":79.584,"date":"","count":17,"signal":"Chronic sinusitis","source":"DrugCentral FAERS","actionTaken":"Reported 17 times (LLR=80)"},{"llr":78.282,"date":"","count":18,"signal":"Paraesthesia oral","source":"DrugCentral FAERS","actionTaken":"Reported 18 times (LLR=78)"},{"llr":71.264,"date":"","count":17,"signal":"Procedural pain","source":"DrugCentral FAERS","actionTaken":"Reported 17 times (LLR=71)"}],"commonSideEffects":[{"effect":"Macular degeneration","drugRate":"LLR 91","severity":"common"},{"effect":"Chronic sinusitis","drugRate":"LLR 80","severity":"common"},{"effect":"Paraesthesia oral","drugRate":"LLR 78","severity":"common"},{"effect":"Procedural pain","drugRate":"LLR 71","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"morphine dinicotinate","offLabel":[],"synonyms":["nicomorphine","morphine dinicotinate"],"timeline":[],"approvals":[],"brandName":"Morphine Dinicotinate","ecosystem":[],"mechanism":{"moaClass":"Full Opioid Agonists","modality":"Small Molecule","drugClass":"Opioid Agonist","explanation":"Imagine your brain has special locks called opioid receptors. NICOMORPHINE is a key that fits into these locks, which helps to block pain signals and produce feelings of relaxation and pain relief. This is how it helps to manage pain, but it can also have other effects on the body.","oneSentence":"NICOMORPHINE works by binding to opioid receptors in the brain, producing feelings of pain relief and potentially other effects.","technicalDetail":"NICOMORPHINE is a morphinan derivative that acts as a potent agonist at mu-opioid receptors (MOR), kappa-opioid receptors (KOR), and delta-opioid receptors (DOR), producing analgesia and potentially other effects through activation of these receptors."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1918","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NICOMORPHINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:56:52.605493","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:25.795637+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"morphine","drugSlug":"morphine","fdaApproval":"","patentExpiry":"Mar 12, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"hydromorphone","drugSlug":"hydromorphone","fdaApproval":"1984-01-11","patentExpiry":"Mar 12, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"oxycodone","drugSlug":"oxycodone","fdaApproval":"1950-04-12","patentExpiry":"Sep 2, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"dihydrocodeine","drugSlug":"dihydrocodeine","fdaApproval":"1958-07-07","relationship":"same-class"},{"drugName":"oxymorphone","drugSlug":"oxymorphone","fdaApproval":"1959-04-02","patentExpiry":"Nov 22, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"naloxone","drugSlug":"naloxone","fdaApproval":"1971-04-13","patentExpiry":"Oct 30, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"naltrexone","drugSlug":"naltrexone","fdaApproval":"1984-11-20","patentExpiry":"Oct 15, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"codeine","drugSlug":"codeine","fdaApproval":"1952-01-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"nicomorphine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"morphine","brandName":"morphine","genericName":"morphine","approvalYear":"","relationship":"same-class"},{"drugId":"hydromorphone","brandName":"hydromorphone","genericName":"hydromorphone","approvalYear":"1984","relationship":"same-class"},{"drugId":"oxycodone","brandName":"oxycodone","genericName":"oxycodone","approvalYear":"1950","relationship":"same-class"},{"drugId":"dihydrocodeine","brandName":"dihydrocodeine","genericName":"dihydrocodeine","approvalYear":"1958","relationship":"same-class"},{"drugId":"oxymorphone","brandName":"oxymorphone","genericName":"oxymorphone","approvalYear":"1959","relationship":"same-class"},{"drugId":"naloxone","brandName":"naloxone","genericName":"naloxone","approvalYear":"1971","relationship":"same-class"},{"drugId":"naltrexone","brandName":"naltrexone","genericName":"naltrexone","approvalYear":"1984","relationship":"same-class"},{"drugId":"codeine","brandName":"codeine","genericName":"codeine","approvalYear":"1952","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"d00308","NDDF":"001545","UNII":"Y95FRL95FW","CHEBI":"CHEBI:135797","VANDF":"4017530","INN_ID":"789","RXNORM":"7052","UMLSCUI":"C0068699","ChEMBL_ID":"CHEMBL2106851","KEGG_DRUG":"D07285","DRUGBANK_ID":"DB13454","PDB_CHEM_ID":" MOI","PUBCHEM_CID":"5362460","SNOMEDCT_US":"373529000","MESH_DESCRIPTOR_UI":"D009020","MESH_SUPPLEMENTAL_RECORD_UI":"C008549"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":46,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"N02AA04","allCodes":["N02AA04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Mar 15","pmid":"38543161","title":"Small-Angle X-ray Scattering (SAXS) Used for the Identification of Nicomorphine Polymorphic Changes at the Early Stage to Avoid Varied Stability and Possible Side Effects.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2021 Sep","pmid":"34528849","title":"Towards identifying nicomorphine administration in doping control: synthesis of metabolites.","journal":"Bioanalysis"},{"date":"2019 Sep","pmid":"30153698","title":"Fast-Track Management in Off-Pump Coronary Artery Bypass Grafting: Dexmedetomidine Provides Rapid Extubation and Effective Pain Modulation.","journal":"The Thoracic and cardiovascular surgeon"},{"date":"2008 Jul 30","pmid":"18585338","title":"A screening test for heroin based on sequential injection analysis with dual-reagent chemiluminescence detection.","journal":"Talanta"},{"date":"2007 Jun","pmid":"17072916","title":"In-hospital use of opioids increases rate of coded postoperative paralytic ileus.","journal":"Pharmacoepidemiology and drug safety"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine dinicotinate is a small molecule. It is also known by various synonyms, including 3,6-DINICOTINOYLMORPHINE, DEA NO. 9312, IDS-NN-003, MORPHINE DINICOTINATE, MORPHINE DINICOTINATE (ESTER), and MORPHINE DINICOTINATE ESTER.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:25.795637+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":false,"score":2}}