{"id":"nicomol","rwe":[{"pmid":"9513376","year":"1998","title":"[Niceritrol decreases serum phosphate levels in chronic hemodialysis patients].","finding":"","journal":"Nihon Jinzo Gakkai shi","studyType":"Clinical Study"},{"pmid":"8312867","year":"1993","title":"Protective effects of various drugs on adriamycin (doxorubicin)-induced toxicity and microsomal lipid peroxidation in mice and rats.","finding":"","journal":"Biological & pharmaceutical bulletin","studyType":"Clinical Study"},{"pmid":"2257963","year":"1990","title":"Effects of ibudilast on calcium deposition in soft tissues of rabbits with atherosclerosis.","finding":"","journal":"The Journal of international medical research","studyType":"Clinical Study"},{"pmid":"3214474","year":"1988","title":"Hypolipidemic effect of NS-1 and other related drugs in rhesus monkeys.","finding":"","journal":"Atherosclerosis","studyType":"Clinical Study"},{"pmid":"2436440","year":"1987","title":"Protection against adriamycin (doxorubicin)-induced toxicity in mice by several clinically used drugs.","finding":"","journal":"Acta medica Okayama","studyType":"Clinical Study"}],"tags":[{"label":"nicomol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Hyperlipidemia","category":"indication"}],"phase":"phase_2","safety":{"contraindications":["Low blood pressure"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cholexamin","offLabel":[],"synonyms":["nicomol","cholexamine","cholexamin"],"timeline":[],"approvals":[],"brandName":"Cholexamin","ecosystem":[{"indication":"Hyperlipidemia","otherDrugs":[{"name":"cholestyramine","slug":"cholestyramine","company":"Bristol Myers"},{"name":"choline fenofibrate","slug":"choline-fenofibrate","company":"Abbvie"},{"name":"clofibrate","slug":"clofibrate","company":""},{"name":"colestipol","slug":"colestipol","company":"Pharmacia And Upjohn"}],"globalPrevalence":390000000}],"mechanism":{"modality":"Small Molecule","drugClass":"nicomol","explanation":"Think of cholesterol as a building block for your body's cells. Cholexamin helps slow down the production of new cholesterol by blocking the enzyme that makes it. This can help lower the amount of cholesterol in your blood, which can reduce your risk of heart disease.","oneSentence":"Cholexamin works by inhibiting the enzyme responsible for cholesterol synthesis.","technicalDetail":"Cholexamin is a nicomol that inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway, thereby reducing cholesterol synthesis in the liver."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1917","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NICOMOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:38:53.931518","biosimilars":[],"competitors":[],"genericName":"nicomol","indications":{"approved":[{"name":"Hyperlipidemia","source":"DrugCentral","snomedId":55822004,"regulator":"FDA","usPrevalence":null,"globalPrevalence":390000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"215U8X2R44","CHEBI":"CHEBI:31904","INN_ID":"2880","UMLSCUI":"C0068698","ChEMBL_ID":"CHEMBL2103919","KEGG_DRUG":"D01291","PUBCHEM_CID":"34081","MESH_SUPPLEMENTAL_RECORD_UI":"C008612"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":9,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"1998 Jan","pmid":"9513376","title":"[Niceritrol decreases serum phosphate levels in chronic hemodialysis patients].","journal":"Nihon Jinzo Gakkai shi"},{"date":"1993 Nov","pmid":"8312867","title":"Protective effects of various drugs on adriamycin (doxorubicin)-induced toxicity and microsomal lipid peroxidation in mice and rats.","journal":"Biological & pharmaceutical bulletin"},{"date":"1990 Sep-Oct","pmid":"2257963","title":"Effects of ibudilast on calcium deposition in soft tissues of rabbits with atherosclerosis.","journal":"The Journal of international medical research"},{"date":"1988 Nov","pmid":"3214474","title":"Hypolipidemic effect of NS-1 and other related drugs in rhesus monkeys.","journal":"Atherosclerosis"},{"date":"1987 Feb","pmid":"2436440","title":"Protection against adriamycin (doxorubicin)-induced toxicity in mice by several clinically used drugs.","journal":"Acta medica Okayama"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cholexamin (NICOMOL) is a small molecule nicomol drug used to treat Hyperlipidemia. Its exact target is unknown, but it is believed to work by inhibiting the synthesis of cholesterol. Cholexamin is a patented drug, but its commercial status as a generic product is unknown. Key safety considerations include unknown half-life and bioavailability. Further research is needed to fully understand its pharmacokinetics and potential side effects.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}