{"id":"nicofibrate","rwe":[],"tags":[{"label":"nicofibrate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anticholesteremic Agents","category":"pharmacology"},{"label":"Antimetabolites","category":"pharmacology"},{"label":"Hypolipidemic Agents","category":"pharmacology"},{"label":"Lipid Regulating Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"clofenpyride","offLabel":[],"synonyms":["nicofibrate","clofenpyride"],"timeline":[],"approvals":[],"brandName":"Clofenpyride","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"nicofibrate","explanation":"Think of it like a traffic cop: ACAT is like a traffic cop that helps cholesterol get into the liver and get stored. By blocking ACAT, Clofenpyride helps reduce the amount of cholesterol that gets stored in the liver, which can help lower cholesterol levels in the blood.","oneSentence":"Clofenpyride works by inhibiting the enzyme acyl-CoA:cholesterol acyltransferase (ACAT), which plays a key role in the formation of cholesterol esters in the liver.","technicalDetail":"Clofenpyride acts as a competitive inhibitor of ACAT, specifically targeting the enzyme's active site and preventing the transfer of fatty acids to cholesterol, thereby reducing the formation of cholesterol esters and increasing the clearance of cholesterol from the bloodstream."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1915","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NICOFIBRATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:09:00.660725","biosimilars":[],"competitors":[],"genericName":"nicofibrate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"4839MB71E7","CHEBI":"CHEBI:135299","INN_ID":"3388","UMLSCUI":"C2698461","ChEMBL_ID":"CHEMBL2106799","PUBCHEM_CID":"65778","MESH_DESCRIPTOR_UI":"D002995"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clofenpyride is a small molecule with synonyms NICOFIBRATE and NICOFIBRATO. Its exact mechanism and indications are not specified in the provided information, but it is classified as a small molecule.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}