{"id":"nicocodine","rwe":[{"pmid":"115478","year":"1979","title":"Reinforcing properties of nicocodine in the rhesus monkey.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"6040366","year":"1967","title":"[Comparative actions of morphine, codeine and nicocodine on respiration and external pancreatic and biliary secretions in the rat].","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"}],"tags":[{"label":"nicocodine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"lyopect","offLabel":[],"synonyms":["nicocodine","codeine nicotinate","lyopect","nicocodine hydrochloride","nicocodine HCl"],"timeline":[],"approvals":[],"brandName":"Lyopect","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"nicocodine","explanation":"Imagine your brain has special locks that control how you feel pain. Lyopect is a key that fits into these locks, changing the way pain signals are sent and received. This can help reduce the sensation of pain, but it can also have other effects on the body.","oneSentence":"Lyopect works by binding to opioid receptors in the brain, altering the perception of pain.","technicalDetail":"Lyopect exerts its effects by interacting with mu-opioid receptors, kappa-opioid receptors, and possibly other targets, leading to analgesia and potential side effects such as respiratory depression and dependence."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1914","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NICOCODINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:38:48.463903","biosimilars":[],"competitors":[],"genericName":"nicocodine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"DYX391P13E","CHEBI":"CHEBI:135650","INN_ID":"1249","UMLSCUI":"C0068697","ChEMBL_ID":"CHEMBL2105136","KEGG_DRUG":"D08272","PUBCHEM_CID":"5463872","SECONDARY_CAS_RN":"58263-01-7","MESH_SUPPLEMENTAL_RECORD_UI":"C021063"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"1979","pmid":"115478","title":"Reinforcing properties of nicocodine in the rhesus monkey.","journal":"Arzneimittel-Forschung"},{"date":"1967 May","pmid":"6040366","title":"[Comparative actions of morphine, codeine and nicocodine on respiration and external pancreatic and biliary secretions in the rat].","journal":"Archives internationales de pharmacodynamie et de therapie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lyopect (NICOCODINE) is a small molecule drug in the nicocodine class, but specific details about its development, commercial status, and approved indications are not available. As a nicocodine, it is likely a centrally acting opioid analgesic, but its exact mechanism and target are unknown. Further research is needed to understand its pharmacological properties and clinical applications. Lyopect's commercial status, including patent status and generic availability, is also unclear. As a result, its safety profile and potential side effects are not well established.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}