{"id":"niclofolan","rwe":[{"pmid":"39802747","year":"2025","title":"Acute Niclofolan Intoxication Led to Stillbirth: A Case Report.","finding":"","journal":"Drug, healthcare and patient safety","studyType":"Clinical Study"},{"pmid":"39047132","year":"2024","title":"OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN PRESUMED VETERINARY ANTHELMINTIC DRUG-INDUCED RETINAL TOXICITY: A Glimpse into Underlying Mechanism.","finding":"","journal":"Retina (Philadelphia, Pa.)","studyType":"Clinical Study"},{"pmid":"32927551","year":"2020","title":"Target and suspect screening analysis reveals persistent emerging organic contaminants in soils and sediments.","finding":"","journal":"The Science of the total environment","studyType":"Clinical Study"},{"pmid":"2133425","year":"1990","title":"Paragonimus and paragonimiasis in Korea.","finding":"","journal":"Kisaengch'unghak chapchi. The Korean journal of parasitology","studyType":"Clinical Study"},{"pmid":"2384912","year":"1990","title":"Pharmacokinetics of niclofolan in desert sheep.","finding":"","journal":"Journal of veterinary pharmacology and therapeutics","studyType":"Clinical Study"}],"tags":[{"label":"niclofolan","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bilevon","offLabel":[],"synonyms":["menichlopholan","menichlofolan","niclofolan","bilevon"],"timeline":[],"approvals":[],"brandName":"Bilevon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"niclofolan","explanation":"Think of it like a lock and key. Bilevon is a key that fits into a specific lock on the surface of certain cells, preventing them from pumping out calcium ions. This can affect how these cells function and communicate with each other.","oneSentence":"Bilevon works by inhibiting the ATPase activity of the calcium pump in the plasma membrane of certain cells.","technicalDetail":"Bilevon specifically inhibits the Ca2+-ATPase pump, a type of P-type ATPase, which is responsible for maintaining calcium homeostasis in various cell types."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1686","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NICLOFOLAN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:56:39.442822","biosimilars":[],"competitors":[],"genericName":"niclofolan","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"82KFT81F6W","CHEBI":"CHEBI:135460","INN_ID":"2566","UMLSCUI":"C0028016","ChEMBL_ID":"CHEMBL2107116","PUBCHEM_CID":"5284586","MESH_DESCRIPTOR_UI":"D009533"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":29,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"39802747","title":"Acute Niclofolan Intoxication Led to Stillbirth: A Case Report.","journal":"Drug, healthcare and patient safety"},{"date":"2024 Aug 1","pmid":"39047132","title":"OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN PRESUMED VETERINARY ANTHELMINTIC DRUG-INDUCED RETINAL TOXICITY: A Glimpse into Underlying Mechanism.","journal":"Retina (Philadelphia, Pa.)"},{"date":"2020 Oct 20","pmid":"32927551","title":"Target and suspect screening analysis reveals persistent emerging organic contaminants in soils and sediments.","journal":"The Science of the total environment"},{"date":"1990 Dec","pmid":"2133425","title":"Paragonimus and paragonimiasis in Korea.","journal":"Kisaengch'unghak chapchi. The Korean journal of parasitology"},{"date":"1990 Jun","pmid":"2384912","title":"Pharmacokinetics of niclofolan in desert sheep.","journal":"Journal of veterinary pharmacology and therapeutics"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bilevon, also known as NICLOFOLAN, is a small molecule niclofolan drug. It is a compound originally developed by, but its current owner is unknown. Bilevon's target and exact mechanism of action are also unknown. It is not FDA-approved for any indications, and its commercial status, including patent status and generic availability, is unclear. Key safety considerations for Bilevon are also unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}