{"id":"nicardipine-verapamil-nitroglycerin","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Reflex tachycardia"},{"rate":null,"effect":"Edema"},{"rate":null,"effect":"Constipation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nicardipine and verapamil are calcium channel blockers that reduce cardiac contractility and peripheral vascular resistance, lowering blood pressure and heart rate. Nitroglycerin is a nitrate vasodilator that preferentially dilates coronary arteries and reduces preload on the heart. Together, these agents work synergistically to decrease myocardial oxygen demand and improve coronary perfusion.","oneSentence":"This combination reduces cardiac workload and improves coronary blood flow by blocking calcium channels (nicardipine and verapamil) and dilating blood vessels (nitroglycerin).","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:57:15.185Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"},{"name":"Coronary artery disease"}]},"trialDetails":[{"nctId":"NCT01996436","phase":"PHASE4","title":"The Intra-arterial Vasospasm Trial","status":"TERMINATED","sponsor":"Peng Roc Chen, MD","startDate":"2016-08-29","conditions":"Cerebral Vasospasm","enrollment":92}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Nicardipine + Verapamil + Nitroglycerin","genericName":"Nicardipine + Verapamil + Nitroglycerin","companyName":"Peng Roc Chen, MD","companyId":"peng-roc-chen-md","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination reduces cardiac workload and improves coronary blood flow by blocking calcium channels (nicardipine and verapamil) and dilating blood vessels (nitroglycerin). Used for Angina pectoris, Hypertension, Coronary artery disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}