{"id":"ngx-4010","safety":{"commonSideEffects":[{"rate":"~50","effect":"Application site erythema"},{"rate":"~40","effect":"Application site pain/burning"},{"rate":"~20","effect":"Application site pruritus"},{"rate":"~30","effect":"Transient increase in local pain"}]},"_chembl":{"chemblId":"CHEMBL4297408","moleculeType":"Small molecule","molecularWeight":"214.33"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The patch delivers high-concentration capsaicin (8%) directly to affected skin, causing initial activation followed by prolonged desensitization of TRPV1-expressing C-fibers. This leads to depletion of the neuropeptide substance P, which is critical for pain signal transmission, resulting in sustained analgesia in the treated area. The mechanism is particularly effective for neuropathic pain conditions where localized nerve damage causes chronic pain.","oneSentence":"NGX-4010 is a topical capsaicin patch that desensitizes nociceptors (pain-sensing nerve fibers) by depleting substance P, reducing localized pain transmission.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:57.469Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postherpetic neuralgia (PHN)"},{"name":"Peripheral neuropathic pain"}]},"trialDetails":[{"nctId":"NCT01713426","phase":"PHASE4","title":"A Study to Compare QUTENZA With Pregabalin for the Treatment of Peripheral Neuropathic Pain (PNP) After 8 Weeks of Treatment","status":"COMPLETED","sponsor":"Astellas Pharma Europe Ltd.","startDate":"2012-07-11","conditions":"Non-diabetic Painful Peripheral Polyneuropathy, Postherpetic Neuralgia (PHN), Peripheral Nerve Injury (PNI)","enrollment":568},{"nctId":"NCT02171182","phase":"","title":"A Study of Efficacy and Safety of Qutenza in Patients With Post-operative Peripheral Neuropathic Pain","status":"COMPLETED","sponsor":"Astellas Pharma s.r.o.","startDate":"2014-01","conditions":"Post-operative Peripheral Neuropathic Pain","enrollment":319},{"nctId":"NCT00321672","phase":"PHASE3","title":"Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy","status":"COMPLETED","sponsor":"NeurogesX","startDate":"2006-06","conditions":"Pain, HIV Infections, Peripheral Nervous System Diseases","enrollment":494},{"nctId":"NCT00916942","phase":"PHASE2","title":"Study of NGX-4010 With the Use of Open Label Lidocaine (2.5%)/Prilocaine (2.5%) Cream for the Treatment of Postherpetic Neuralgia (PHN)","status":"COMPLETED","sponsor":"NeurogesX","startDate":"2009-06","conditions":"Postherpetic Neuralgia","enrollment":20},{"nctId":"NCT00254449","phase":"PHASE1","title":"Effect of NGX-4010 on ENFD and Sensory Function","status":"COMPLETED","sponsor":"NeurogesX","startDate":"2005-11","conditions":"Human Volunteers","enrollment":36},{"nctId":"NCT00300222","phase":"PHASE3","title":"Study of NGX-4010 for the Treatment of Postherpetic Neuralgia","status":"COMPLETED","sponsor":"NeurogesX","startDate":"2006-03","conditions":"Peripheral Nervous System Diseases, Pain, Neuralgia","enrollment":400},{"nctId":"NCT00115310","phase":"PHASE3","title":"Study of NGX-4010 for the Treatment of Postherpetic Neuralgia","status":"COMPLETED","sponsor":"NeurogesX","startDate":"2005-06","conditions":"Peripheral Nervous System Diseases, Pain, Neuralgia","enrollment":400},{"nctId":"NCT00064623","phase":"PHASE3","title":"Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy","status":"COMPLETED","sponsor":"NeurogesX","startDate":"2003-08","conditions":"HIV Infections, Peripheral Nervous System Diseases, Pain","enrollment":300},{"nctId":"NCT00061776","phase":"PHASE2, PHASE3","title":"NGX-4010 for the Treatment of Postherpetic Neuralgia","status":"COMPLETED","sponsor":"NeurogesX","startDate":"","conditions":"Herpes Zoster, Neuralgia, Pain","enrollment":300},{"nctId":"NCT00068081","phase":"PHASE3","title":"Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia","status":"COMPLETED","sponsor":"NeurogesX","startDate":"","conditions":"Herpes Zoster, Neuralgia, Pain","enrollment":150},{"nctId":"NCT00085761","phase":"PHASE3","title":"Study of NGX-4010 for Treatment of Painful HIV-Associated Neuropathy","status":"TERMINATED","sponsor":"NeurogesX","startDate":"","conditions":"HIV Infections, Peripheral Nervous System Diseases, Pain","enrollment":""},{"nctId":"NCT00233155","phase":"PHASE2","title":"Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy (HIV-AN) or Postherpetic Neuralgia (PHN)","status":"COMPLETED","sponsor":"NeurogesX","startDate":"2005-08","conditions":"Herpes Zoster, Neuralgia, Pain","enrollment":100},{"nctId":"NCT00082316","phase":"PHASE2","title":"Tolerability of Three Local Anesthetic Formulations in Conjunction With NGX-4010 for the Treatment of Neuropathic Pain","status":"COMPLETED","sponsor":"NeurogesX","startDate":"","conditions":"Herpes Zoster, Neuralgia, Pain","enrollment":""},{"nctId":"NCT00089557","phase":"PHASE2","title":"An Open-Label Extension Study of NGX-4010 for the Treatment of Neuropathic Pain","status":"TERMINATED","sponsor":"NeurogesX","startDate":"","conditions":"Herpes Zoster, Neuralgia, Pain","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":24,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"NGX-4010","genericName":"NGX-4010","companyName":"NeurogesX","companyId":"neurogesx","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NGX-4010 is a topical capsaicin patch that desensitizes nociceptors (pain-sensing nerve fibers) by depleting substance P, reducing localized pain transmission. Used for Postherpetic neuralgia (PHN), Peripheral neuropathic pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}