{"id":"neuronox-r","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or bruising"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Muscle weakness in adjacent muscles"},{"rate":null,"effect":"Ptosis (eyelid drooping)"},{"rate":null,"effect":"Dry mouth"}]},"_chembl":{"chemblId":"CHEMBL89731","moleculeType":"Small molecule","molecularWeight":"159.14"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Neuronox works by cleaving SNARE proteins required for acetylcholine vesicle fusion and release at the neuromuscular junction. This results in temporary paralysis of targeted muscles, reducing involuntary contractions and muscle hyperactivity. The effect is localized to injected muscles and gradually reverses over 3-4 months as new neuromuscular junctions form.","oneSentence":"Neuronox is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:21.784Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Wrinkle reduction (cosmetic use)"}]},"trialDetails":[{"nctId":"NCT03805152","phase":"PHASE3","title":"Abobotulinum Toxin and Neubotulinum Toxin Injection in Cerivical Dystonia","status":"COMPLETED","sponsor":"Department of Medical Services Ministry of Public Health of Thailand","startDate":"2019-10-25","conditions":"Cervical Dystonia","enrollment":52}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Intramuscular injection"],"phase":"phase_3","status":"active","brandName":"Neuronox(R)","genericName":"Neuronox(R)","companyName":"Department of Medical Services Ministry of Public Health of Thailand","companyId":"department-of-medical-services-ministry-of-public-health-of-thailand","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Neuronox is a botulinum toxin type A preparation that blocks acetylcholine release at the neuromuscular junction to reduce muscle contractions. Used for Cervical dystonia, Blepharospasm, Hemifacial spasm.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}