{"id":"neupogen-5-g-kg-day","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Bone pain"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Fatigue"},{"rate":"5-10","effect":"Injection site reactions"},{"rate":"5-10","effect":"Splenomegaly"},{"rate":"5-10","effect":"Elevated uric acid"}]},"_chembl":{"chemblId":"CHEMBL3932957","moleculeType":"Small molecule","molecularWeight":"459.46"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Filgrastim is a recombinant human granulocyte colony-stimulating factor (G-CSF) that binds to G-CSF receptors on hematopoietic progenitor cells in the bone marrow. This binding promotes proliferation, differentiation, and activation of neutrophil precursors, leading to increased production and mobilization of mature neutrophils into the bloodstream. It is used to mitigate chemotherapy-induced neutropenia and mobilize peripheral blood progenitor cells for transplantation.","oneSentence":"Neupogen (filgrastim) stimulates the bone marrow to produce and release neutrophils, increasing white blood cell counts to prevent or treat infections in immunocompromised patients.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:52.752Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced neutropenia (CIN) in cancer patients"},{"name":"Severe chronic neutropenia"},{"name":"Peripheral blood progenitor cell (PBPC) mobilization for autologous transplantation"}]},"trialDetails":[{"nctId":"NCT03263936","phase":"PHASE1","title":"Epigenetic Reprogramming in Relapse/Refractory AML","status":"COMPLETED","sponsor":"Therapeutic Advances in Childhood Leukemia Consortium","startDate":"2017-07-11","conditions":"Acute Myelogenous Leukemia","enrollment":37},{"nctId":"NCT03504410","phase":"PHASE3","title":"Efficacy/Safety of CPI-613 in Combination With HD Cyt. and Mito. vs HD Cyt. and Mito. in Older Patients With R/R AML","status":"TERMINATED","sponsor":"Cornerstone Pharmaceuticals","startDate":"2018-11-12","conditions":"Relapsed/Refractory Acute Myeloid Leukemia","enrollment":200},{"nctId":"NCT03343145","phase":"PHASE3","title":"A Study to Evaluate the Efficacy, Safety and Immunogenicity of Leucostim® Versus Neupogen® in Breast Cancer Patients","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2017-01-12","conditions":"Breast Cancer","enrollment":143},{"nctId":"NCT01541072","phase":"NA","title":"Lymphocyte Reconstitution After Administration of Pegfilgrastim Versus Filgrastim After Peripheral Stem Cell Transplantation","status":"TERMINATED","sponsor":"Centre Leon Berard","startDate":"2012-02","conditions":"Non Hodgkin Lymphoma","enrollment":34},{"nctId":"NCT00682383","phase":"PHASE2","title":"Combined Modality Therapy With Growth Factor Support in Locally Advanced Non-small Cell Lung Cancer (NSCLC)","status":"COMPLETED","sponsor":"Mt. Sinai Medical Center, Miami","startDate":"2003-09","conditions":"Unresectable Locally Advanced NSCLC","enrollment":26}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Neupogen 5µg/kg/day","genericName":"Neupogen 5µg/kg/day","companyName":"Dong-A ST Co., Ltd.","companyId":"dong-a-st-co-ltd","modality":"Biologic","firstApprovalDate":"","aiSummary":"Neupogen (filgrastim) stimulates the bone marrow to produce and release neutrophils, increasing white blood cell counts to prevent or treat infections in immunocompromised patients. Used for Chemotherapy-induced neutropenia (CIN) in cancer patients, Severe chronic neutropenia, Peripheral blood progenitor cell (PBPC) mobilization for autologous transplantation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}