{"id":"netildex-ophthalmic-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or discomfort"},{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Allergic conjunctivitis"},{"rate":null,"effect":"Increased intraocular pressure (with prolonged corticosteroid use)"}]},"_chembl":{"chemblId":"CHEMBL2109015","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Netilmicin works by inhibiting bacterial protein synthesis, thereby providing broad-spectrum antimicrobial coverage against gram-positive and gram-negative ocular pathogens. Dexamethasone suppresses the inflammatory response by inhibiting phospholipase A2 and reducing prostaglandin and leukotriene production, thereby decreasing ocular inflammation, edema, and discomfort associated with infection or post-operative states.","oneSentence":"NETILDEX is a combination ophthalmic gel containing netilmicin (an aminoglycoside antibiotic) and dexamethasone (a corticosteroid) that reduces bacterial infection and inflammation in the eye.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:22:52.345Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial ocular infections with associated inflammation"},{"name":"Post-operative ocular inflammation and infection prophylaxis"}]},"trialDetails":[{"nctId":"NCT02973880","phase":"PHASE3","title":"Clinical Study to Evaluate the Efficacy and Tolerability of an Anti-inflammatory/Antibiotic Treatment Following Ocular Cataract Extraction","status":"COMPLETED","sponsor":"SIFI SpA","startDate":"2017-10-15","conditions":"Cataract Extraction, Cataract","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"NETILDEX™ ophthalmic gel","genericName":"NETILDEX™ ophthalmic gel","companyName":"SIFI SpA","companyId":"sifi-spa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NETILDEX is a combination ophthalmic gel containing netilmicin (an aminoglycoside antibiotic) and dexamethasone (a corticosteroid) that reduces bacterial infection and inflammation in the eye. Used for Bacterial ocular infections with associated inflammation, Post-operative ocular inflammation and infection prophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}