{"id":"ner1006-day-before-only-dosing","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"NER1006 works as an osmotic laxative containing PEG 3350 and electrolytes that create an osmotic gradient in the bowel, pulling water into the intestinal lumen and promoting rapid evacuation of fecal material. The 'Day Before-Only' formulation is designed to be administered as a single-day regimen (typically the day before colonoscopy) rather than split-dose protocols, improving patient compliance and tolerability while maintaining efficacy for bowel preparation.","oneSentence":"NER1006 is a polyethylene glycol (PEG)-based bowel cleansing agent that osmotically draws fluid into the colon to evacuate intestinal contents.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:23:01.146Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel cleansing prior to colonoscopy"}]},"trialDetails":[{"nctId":"NCT02273141","phase":"PHASE3","title":"Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus a Sodium Picosulfate and Magnesium Salt Solution Using Day Before-Only Dosing Regimen in Adults.","status":"COMPLETED","sponsor":"Norgine","startDate":"2014-11","conditions":"Colorectal Cancer, Colorectal Carcinoma, Colon Cleansing","enrollment":515}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"NER1006, Day Before-Only Dosing","genericName":"NER1006, Day Before-Only Dosing","companyName":"Norgine","companyId":"norgine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NER1006 is a small molecule used in a study to compare its bowel cleansing efficacy, safety, and tolerability against a sodium picosulfate and magnesium salt solution in adults with conditions such as colorectal cancer, colorectal carcinoma, and colon cleansing. The study, NER1006-03/2014 (DAYB), used a day before-only dosing regimen.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}