{"id":"nepinalone","rwe":[{"pmid":"22711801","year":"2012","title":"Identifying mechanism-of-action targets for drugs and probes.","finding":"","journal":"Proceedings of the National Academy of Sciences of the United States of America","studyType":"Clinical Study"}],"tags":[{"label":"nepinalone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sigma non-opioid intracellular receptor 1","category":"target"},{"label":"SIGMAR1","category":"gene"},{"label":"R05DB26","category":"atc"},{"label":"Active","category":"status"},{"label":"Non-productive cough","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["nepinalone hydrochloride","nepinalone HCl","nepinalone"],"offLabel":[],"synonyms":["nepinalone hydrochloride","nepinalone HCl","nepinalone"],"timeline":[],"approvals":[],"ecosystem":[{"indication":"Non-productive cough","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Sigma non-opioid intracellular receptor 1","targets":[{"gene":"SIGMAR1","source":"DrugCentral","target":"Sigma non-opioid intracellular receptor 1","protein":"Sigma non-opioid intracellular receptor 1"}],"modality":"Small Molecule","drugClass":"nepinalone","explanation":"Imagine your body has a special switch that controls coughing. When this switch gets stuck, it can cause persistent coughing. Nepinalone is like a key that fits into this switch, helping to turn it off and stop the coughing.","oneSentence":"Nepinalone works by binding to the Sigma non-opioid intracellular receptor 1, which helps to reduce coughing.","technicalDetail":"Nepinalone exerts its effects by selectively binding to the sigma-1 receptor, a subtype of the sigma receptor family, which is involved in various physiological processes including cough modulation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1900","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NEPINALONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:55:58.335244","biosimilars":[],"competitors":[{"drugName":"benzonatate","drugSlug":"benzonatate","fdaApproval":"1958-02-10","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pentoxyverine","drugSlug":"pentoxyverine","fdaApproval":"","relationship":"same-class"},{"drugName":"clofedanol","drugSlug":"clofedanol","fdaApproval":"","relationship":"same-class"}],"genericName":"nepinalone","indications":{"approved":[{"name":"Non-productive cough","source":"DrugCentral","snomedId":409596002,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"benzonatate","brandName":"benzonatate","genericName":"benzonatate","approvalYear":"1958","relationship":"same-class"},{"drugId":"pentoxyverine","brandName":"pentoxyverine","genericName":"pentoxyverine","approvalYear":"","relationship":"same-class"},{"drugId":"clofedanol","brandName":"clofedanol","genericName":"clofedanol","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"L9806LPR7G","CHEBI":"CHEBI:135121","INN_ID":"6490","UMLSCUI":"C2698448","ChEMBL_ID":"CHEMBL2105148","KEGG_DRUG":"D07396","DRUGBANK_ID":"DB13445","PUBCHEM_CID":"3047788","SECONDARY_CAS_RN":"22443-55-6"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"R05DB26","allCodes":["R05DB26"]},"biosimilarFilings":[],"recentPublications":[{"date":"2012 Jul 10","pmid":"22711801","title":"Identifying mechanism-of-action targets for drugs and probes.","journal":"Proceedings of the National Academy of Sciences of the United States of America"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"NEPINALONE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nepinalone is a small molecule. It has multiple synonyms, including Nepinalona and Nepinalone.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}