{"id":"neostigmine-atropin-biotika","safety":{"commonSideEffects":[{"rate":null,"effect":"Muscle fasciculations"},{"rate":null,"effect":"Increased salivation"},{"rate":null,"effect":"Bronchospasm"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea and vomiting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Neostigmine is a reversible cholinesterase inhibitor that prevents the breakdown of acetylcholine by blocking the enzyme acetylcholinesterase. This leads to increased acetylcholine concentration at the neuromuscular junction, enhancing parasympathomimetic effects and improving muscle strength in conditions characterized by neuromuscular dysfunction. Atropine is often co-administered to counteract the muscarinic side effects of neostigmine.","oneSentence":"Neostigmine inhibits acetylcholinesterase, allowing acetylcholine to accumulate at neuromuscular junctions and enhance muscle contraction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:56:55.764Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Myasthenia gravis"},{"name":"Postoperative ileus and urinary retention"},{"name":"Reversal of neuromuscular blockade"}]},"trialDetails":[{"nctId":"NCT03420937","phase":"PHASE4","title":"Deep Neuromuscular Block During General Anaesthesia in Robotic Surgery","status":"COMPLETED","sponsor":"University Hospital Olomouc","startDate":"2016-06","conditions":"Observation of Neuromuscular Block, Complication of Ventilation Therapy, Postoperative Recovery","enrollment":138}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["syntostigmine, atropine"],"phase":"marketed","status":"active","brandName":"Neostigmine, Atropin Biotika","genericName":"Neostigmine, Atropin Biotika","companyName":"University Hospital Olomouc","companyId":"university-hospital-olomouc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Neostigmine inhibits acetylcholinesterase, allowing acetylcholine to accumulate at the neuromuscular junction and enhance muscle contraction. Used for Myasthenia gravis, Reversal of neuromuscular blockade, Postoperative urinary retention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}