{"id":"neonatal-morphine-solution","safety":{"commonSideEffects":[{"rate":"null","effect":"Respiratory depression"},{"rate":"null","effect":"Nausea and vomiting"},{"rate":"null","effect":"Constipation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Morphine works by activating mu-opioid receptors, which are responsible for pain perception and modulation. This activation leads to a decrease in the transmission of pain signals to the brain, resulting in analgesia. Additionally, morphine can cause sedation and respiratory depression due to its effects on other opioid receptors.","oneSentence":"Morphine is a potent opioid agonist that binds to opioid receptors in the brain and spinal cord, producing analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:50:25.031Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neonatal abstinence syndrome"}]},"trialDetails":[{"nctId":"NCT06341049","phase":"NA","title":"Effect of Three Different Postcesarean Analgesic Techniques on QbsQor-10 Score","status":"COMPLETED","sponsor":"Ataturk University","startDate":"2024-03-12","conditions":"Postoperative Recovery","enrollment":120},{"nctId":"NCT03677830","phase":"PHASE4","title":"Postoperative Pain Control & Relief in Neonates","status":"TERMINATED","sponsor":"St. Louis University","startDate":"2019-04-19","conditions":"Pain, Postoperative, Premature Infant, Opioid Use","enrollment":11},{"nctId":"NCT03762317","phase":"PHASE4","title":"Clonidine as Adjunct to Morphine for Neonatal Abstinence Syndrome","status":"TERMINATED","sponsor":"Hennepin County Medical Center, Minneapolis","startDate":"2018-04-30","conditions":"Neonatal Abstinence Syndrome","enrollment":10},{"nctId":"NCT00715988","phase":"PHASE1","title":"Methadone Pharmacokinetics and Cardiac Effects in Newborns","status":"COMPLETED","sponsor":"University of Utah","startDate":"2007-10","conditions":"Pain","enrollment":7},{"nctId":"NCT01452789","phase":"PHASE3","title":"Blinded Trial of Buprenorphine or Morphine in the Treatment of the Neonatal Abstinence Syndrome","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2011-11","conditions":"Neonatal Abstinence Syndrome","enrollment":63},{"nctId":"NCT01958476","phase":"PHASE3","title":"Improving Outcomes in Neonatal Abstinence Syndrome","status":"COMPLETED","sponsor":"Tufts Medical Center","startDate":"2013-09","conditions":"Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal","enrollment":117},{"nctId":"NCT01708707","phase":"PHASE2","title":"Comparison of Buprenorphine to Morphine in Treatment of Neonatal Abstinence Syndrome (NAS)","status":"COMPLETED","sponsor":"Pediatrix","startDate":"2012-12","conditions":"Neonatal Abstinence Syndrome, Neonatal Withdrawal Syndrome","enrollment":29},{"nctId":"NCT01327079","phase":"PHASE1, PHASE2","title":"The Use of Methadone in Newborn Infants","status":"COMPLETED","sponsor":"John van den Anker","startDate":"2010-12","conditions":"Premature Birth of Newborn, Critically Ill","enrollment":60},{"nctId":"NCT00521248","phase":"PHASE1","title":"Buprenorphine for the Treatment of Neonatal Abstinence Syndrome","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2004-04","conditions":"Neonatal Abstinence Syndrome","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Morphine sulfate"],"phase":"phase_3","status":"active","brandName":"Neonatal Morphine Solution","genericName":"Neonatal Morphine Solution","companyName":"Tufts Medical Center","companyId":"tufts-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine is a potent opioid agonist that binds to opioid receptors in the brain and spinal cord, producing analgesia and sedation. Used for Neonatal abstinence syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}