{"id":"neomycin-oral-product","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal cramping"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Neomycin works by irreversibly binding to the bacterial 30S ribosomal subunit, disrupting the translation of mRNA into proteins and ultimately causing bacterial cell death. As an oral formulation, it is poorly absorbed from the gastrointestinal tract and acts locally within the gut, making it useful for reducing intestinal bacterial flora. This mechanism makes it effective for pre-operative bowel sterilization and treatment of certain gastrointestinal infections.","oneSentence":"Neomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:56:57.246Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pre-operative bowel sterilization"},{"name":"Hepatic encephalopathy (adjunctive therapy)"},{"name":"Bacterial gastroenteritis"}]},"trialDetails":[{"nctId":"NCT01731236","phase":"EARLY_PHASE1","title":"CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2011-02-11","conditions":"Dietary Modification","enrollment":100},{"nctId":"NCT06148025","phase":"PHASE4","title":"Antibiotics and Vaccine Immune Responses Study","status":"RECRUITING","sponsor":"South Australian Health and Medical Research Institute","startDate":"2023-11-23","conditions":"Vaccine Response Impaired","enrollment":348},{"nctId":"NCT07180615","phase":"PHASE4","title":"Gut Decolonisation With Neomycin/Metronidazole or Rifaximin Before Colon Surgery","status":"NOT_YET_RECRUITING","sponsor":"Universität Luzern","startDate":"2026-06-01","conditions":"Surgical Site Infection, Colon Surgery, Surgical Site Infections","enrollment":458},{"nctId":"NCT05354102","phase":"PHASE1","title":"A First-in-human (FIH) Combination Treatment Study With a Single Dose Level of BMC128","status":"ACTIVE_NOT_RECRUITING","sponsor":"Biomica Ltd.","startDate":"2022-05-01","conditions":"Non-small Cell Lung Cancer, Melanoma, Renal Cell Carcinoma","enrollment":11},{"nctId":"NCT02099240","phase":"EARLY_PHASE1","title":"Patients Response to Early Switch To Oral:Osteomyelitis Study","status":"TERMINATED","sponsor":"Julio Ramirez","startDate":"2014-03-06","conditions":"Osteomyelitis","enrollment":11},{"nctId":"NCT01524744","phase":"PHASE2","title":"A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus","status":"UNKNOWN","sponsor":"Mashhad University of Medical Sciences","startDate":"2009-03","conditions":"Oral Lichen Planus","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Neo-Fradin"],"phase":"marketed","status":"active","brandName":"Neomycin Oral Product","genericName":"Neomycin Oral Product","companyName":"South Australian Health and Medical Research Institute","companyId":"south-australian-health-and-medical-research-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Neomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Used for Suppression of intestinal bacterial flora, Hepatic encephalopathy, Traveler's diarrhea prophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}