{"id":"neomycin","rwe":[],"_fda":{"id":"3aea3e3c-519b-7eb7-e063-6394a90a0c71","set_id":"0070ea5f-434d-53a7-e063-6294a90abf18","openfda":{"unii":["89Y4M234ES","057Y626693","19371312D4"],"route":["TOPICAL"],"rxcui":["204602"],"spl_id":["3aea3e3c-519b-7eb7-e063-6394a90a0c71"],"brand_name":["health and .beyond Triple Antibiotic"],"spl_set_id":["0070ea5f-434d-53a7-e063-6294a90abf18"],"package_ndc":["43473-050-01"],"product_ndc":["43473-050"],"generic_name":["BACITRACIN ZINC, NEOMYCIN SULFATE, POLYMYXIN B SULFATE"],"product_type":["HUMAN OTC DRUG"],"substance_name":["BACITRACIN ZINC","NEOMYCIN SULFATE","POLYMYXIN B SULFATE"],"manufacturer_name":["Nantong Health & Beyond Hygienic Products Inc."],"application_number":["M004"],"is_original_packager":[true]},"purpose":["Purpose first aid antibiotic"],"version":"3","stop_use":["Stop use and ask a doctor if if the condition persists or gets worse a rash or other allergic reaction develops."],"warnings":["Warnings For external use only."],"ask_doctor":["Ask a doctor before use if you have deep or puncture wounds animal bites serious burns"],"do_not_use":["Do not use in eyes over large areas of the body if you are allergic to any of the ingredients longer than 1 week unless directed by a doctor"],"effective_time":"20250727","active_ingredient":["Active Ingredients (in each gram) Bacitracin zinc (bacitracin 400 units) Neomycin sulfate（neomycin 3.5 mg） Polymyxin B sulfate (polymyxin B 5,000 units)"],"inactive_ingredient":["Inactive Ingredients White petrolatum"],"storage_and_handling":["Other Information Store at room temperature"],"indications_and_usage":["Uses First aid to help prevent infection in minor cuts, scrapes and burns"],"dosage_and_administration":["Directions Clean the affected area Apply a small amount of this product (an amount equal to the surface area of the tip of a finger) on the area 1 to 3 times daily May be covered with a sterile bandage."],"spl_product_data_elements":["health and .beyond Triple Antibiotic Bacitracin zinc, Neomycin sulfate, Polymyxin B sulfate PETROLATUM BACITRACIN ZINC BACITRACIN NEOMYCIN SULFATE NEOMYCIN POLYMYXIN B SULFATE POLYMYXIN B"],"keep_out_of_reach_of_children":["Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away."],"package_label_principal_display_panel":["image description"]},"tags":[{"label":"Aminoglycoside Antibacterial","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Transient receptor potential cation channel subfamily V member 1","category":"target"},{"label":"TRPV1","category":"gene"},{"label":"LRAT","category":"gene"},{"label":"MEN1","category":"gene"},{"label":"A01AB08","category":"atc"},{"label":"Topical","category":"route"},{"label":"Cream","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Established","category":"status"},{"label":"Bacterial keratitis","category":"indication"},{"label":"Blepharoconjunctivitis","category":"indication"},{"label":"Corneal abrasion","category":"indication"},{"label":"Hepatic coma","category":"indication"},{"label":"Hepatic encephalopathy","category":"indication"},{"label":"Infective blepharitis","category":"indication"},{"label":"Monarch Pharms","category":"company"},{"label":"Approved 1950s","category":"decade"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Protein Synthesis Inhibitors","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"887 reports"},{"date":"","signal":"DRUG HYPERSENSITIVITY","source":"FDA FAERS","actionTaken":"849 reports"},{"date":"","signal":"PAIN","source":"FDA FAERS","actionTaken":"787 reports"},{"date":"","signal":"OFF LABEL USE","source":"FDA FAERS","actionTaken":"751 reports"},{"date":"","signal":"MALAISE","source":"FDA FAERS","actionTaken":"745 reports"},{"date":"","signal":"RASH","source":"FDA FAERS","actionTaken":"736 reports"},{"date":"","signal":"VOMITING","source":"FDA FAERS","actionTaken":"708 reports"},{"date":"","signal":"INFUSION RELATED REACTION","source":"FDA FAERS","actionTaken":"703 reports"},{"date":"","signal":"PYREXIA","source":"FDA FAERS","actionTaken":"691 reports"},{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"686 reports"}],"drugInteractions":[{"url":"/drug/pancuronium","drug":"pancuronium","action":"Monitor closely","effect":"May interact with Pancuronium","source":"DrugCentral","drugSlug":"pancuronium"},{"url":"/drug/pipecuronium","drug":"pipecuronium","action":"Monitor closely","effect":"May interact with Pipecuronium","source":"DrugCentral","drugSlug":"pipecuronium"},{"url":"/drug/rocuronium","drug":"rocuronium","action":"Monitor closely","effect":"May interact with Rocuronium Bromide","source":"DrugCentral","drugSlug":"rocuronium"},{"url":"/drug/suxamethonium","drug":"suxamethonium","action":"Monitor closely","effect":"May interact with Succinylcholine","source":"DrugCentral","drugSlug":"suxamethonium"},{"url":"/drug/tubocurarine","drug":"tubocurarine","action":"Monitor closely","effect":"May interact with Tubocurarine","source":"DrugCentral","drugSlug":"tubocurarine"},{"url":"/drug/vecuronium","drug":"vecuronium","action":"Monitor closely","effect":"May interact with Vecuronium","source":"DrugCentral","drugSlug":"vecuronium"}],"commonSideEffects":[{"effect":"Allergic contact dermatitis","drugRate":"1%","severity":"common","organSystem":""},{"effect":"Allergic skin reactions","drugRate":"0.09%","severity":"common","organSystem":""},{"effect":"Skin sensitization","drugRate":"","severity":"common","organSystem":""},{"effect":"Itching","drugRate":"","severity":"common","organSystem":""},{"effect":"Burning","drugRate":"","severity":"common","organSystem":""},{"effect":"Irritation","drugRate":"","severity":"common","organSystem":""},{"effect":"Dryness","drugRate":"","severity":"common","organSystem":""},{"effect":"Folliculitis","drugRate":"","severity":"common","organSystem":""},{"effect":"Hypertrichosis","drugRate":"","severity":"common","organSystem":""},{"effect":"Acneiform eruptions","drugRate":"","severity":"common","organSystem":""},{"effect":"Hypopigmentation","drugRate":"","severity":"common","organSystem":""},{"effect":"Perioral dermatitis","drugRate":"","severity":"common","organSystem":""},{"effect":"Maceration of the skin","drugRate":"","severity":"common","organSystem":""},{"effect":"Secondary infection","drugRate":"","severity":"common","organSystem":""},{"effect":"Skin atrophy","drugRate":"","severity":"common","organSystem":""},{"effect":"Striae","drugRate":"","severity":"common","organSystem":""},{"effect":"Miliaria","drugRate":"","severity":"common","organSystem":""}],"contraindications":["Adrenal cortical hypofunction","Atrophoderma","Auditory Neurotoxicity","Bacterial infection of eye","Bullous myringitis","Dehydration","Diabetes mellitus","Disorder of the 8th Cranial Nerve","Eye infection","Fungal ear infection","Fungal infection of eye","Gastrointestinal obstruction","Hearing disorder","Herpes simplex","Herpes simplex dendritic keratitis","Herpes simplex keratitis","Herpes zoster auricularis","Hypocalcemia","Hypovolemia","Infant Botulism","Injury of eye region","Kidney disease","Krukenberg spindle","Myasthenia gravis","Neuromuscular block, function"],"specialPopulations":{"Pregnancy":"See WARNINGS section.","Paediatric use":"The safety and efficacy of oral neomycin sulfate in patients less than 18 years of age have not been established. If treatment of patient less than 18 years of age is necessary, neomycin should be used with caution and the period of treatment should not exceed two weeks because of absorption from the gastrointestinal tract."},"seriousAdverseEvents":[{"effect":"Ototoxicity","drugRate":"","severity":"serious"},{"effect":"Nephrotoxicity","drugRate":"","severity":"serious"}]},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[{"market":"United States","source":"CMS National Average Drug Acquisition Cost (NADAC)","asOfDate":"2024-01-03","unitCost":"$0.9221/EA","priceType":"NADAC","sourceUrl":"https://data.medicaid.gov/dataset/4j6z-xnwq","annualCost":"$337","description":"NEOMYCIN 500 MG TABLET","retrievedDate":"2026-04-07"}],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=NEOMYCIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:39:39.769964+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Neomycin","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T01:39:46.672351+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:39:45.256597+00:00"},"regulatory.us":{"url":"","method":"api_direct","source":"FDA Drugs@FDA","rawText":"","confidence":1,"sourceType":"fda_drugsfda","retrievedAt":"2026-04-20T01:39:38.881823+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NEOMYCIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:39:45.500912+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:39:29.072858+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:39:29.072887+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T01:39:47.314667+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL3754093/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:39:46.300838+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"M004","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:39:29.072890+00:00"}},"allNames":"cortisporin","offLabel":[],"synonyms":["neomycin sulfate","neomycin","bykomycin","endomixin","fradiomycin sulfate","mycerin sulfate","neomycin sulphate","neomycin palmitate"],"timeline":[{"date":"1957-03-26","type":"positive","source":"DrugCentral","milestone":"FDA approval (Monarch Pharms)"}],"aiSummary":"Cortisporin (NEOMYCIN) is a small molecule aminoglycoside antibacterial developed by Monarch Pharms, targeting the transient receptor potential cation channel subfamily V member 1. It was FDA-approved in 1957 for various bacterial infections, including keratitis, blepharoconjunctivitis, and hepatic encephalopathy. As an off-patent medication, Cortisporin is available from multiple generic manufacturers. Key safety considerations include its low bioavailability of 3% and potential ototoxicity. Cortisporin is used to treat a range of bacterial infections.","approvals":[{"date":"1957-03-26","orphan":false,"company":"MONARCH PHARMS","regulator":"FDA"}],"brandName":"Cortisporin","ecosystem":[{"indication":"Bacterial keratitis","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"bacitracin","slug":"bacitracin","company":"Pharmacia And Upjohn"},{"name":"cortisone acetate","slug":"cortisone-acetate","company":""},{"name":"dexamethasone","slug":"dexamethasone","company":""}],"globalPrevalence":6000000},{"indication":"Blepharoconjunctivitis","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"bacitracin","slug":"bacitracin","company":"Pharmacia And Upjohn"},{"name":"cortisone acetate","slug":"cortisone-acetate","company":""},{"name":"dexamethasone","slug":"dexamethasone","company":""}],"globalPrevalence":null},{"indication":"Corneal abrasion","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"bacitracin","slug":"bacitracin","company":"Pharmacia And Upjohn"},{"name":"cortisone acetate","slug":"cortisone-acetate","company":""},{"name":"dexamethasone","slug":"dexamethasone","company":""}],"globalPrevalence":null},{"indication":"Hepatic coma","otherDrugs":[{"name":"erythromycin ethyl succinate","slug":"erythromycin-ethyl-succinate","company":"Arbor Pharms Llc"},{"name":"paromomycin","slug":"paromomycin","company":""}],"globalPrevalence":null},{"indication":"Hepatic encephalopathy","otherDrugs":[{"name":"lactulose","slug":"lactulose","company":""},{"name":"rifaximin","slug":"rifaximin","company":"Salix Pharms"}],"globalPrevalence":null},{"indication":"Infective blepharitis","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"bacitracin","slug":"bacitracin","company":"Pharmacia And Upjohn"},{"name":"cortisone acetate","slug":"cortisone-acetate","company":""},{"name":"dexamethasone","slug":"dexamethasone","company":""}],"globalPrevalence":null},{"indication":"Keratitis","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"bacitracin","slug":"bacitracin","company":"Pharmacia And Upjohn"},{"name":"cortisone acetate","slug":"cortisone-acetate","company":""},{"name":"dexamethasone","slug":"dexamethasone","company":""}],"globalPrevalence":6000000},{"indication":"Mastoidectomy Cavity Infections","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"colistin","slug":"colistin","company":"Par Sterile Products"},{"name":"cortisone acetate","slug":"cortisone-acetate","company":""},{"name":"hydrocortisone","slug":"hydrocortisone","company":"Merck"}],"globalPrevalence":null}],"mechanism":{"target":"Transient receptor potential cation channel subfamily V member 1","novelty":"Follow-on","targets":[{"gene":"TRPV1","source":"DrugCentral","target":"Transient receptor potential cation channel subfamily V member 1","protein":"Transient receptor potential cation channel subfamily V member 1"},{"gene":"LRAT","source":"DrugCentral","target":"Lecithin retinol acyltransferase","protein":"Lecithin retinol acyltransferase"},{"gene":"MEN1","source":"DrugCentral","target":"Menin","protein":"Menin"}],"modality":"Small Molecule","drugClass":"Aminoglycoside Antibacterial","explanation":"","oneSentence":"","technicalDetail":"Cortisporin exerts its antibacterial effects by binding to the bacterial cell membrane, specifically targeting the transient receptor potential cation channel subfamily V member 1 (TRPV1), which is essential for bacterial cell membrane function and integrity."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Neomycin%2Fpolymyxin_B%2Fhydrocortisone","title":"Neomycin/polymyxin B/hydrocortisone","extract":"Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa and certain eye disorders. It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone. It is used as an ear drop or eye drop.","wiki_history":"==History==\nCortisporin was developed by Glaxo Wellcome and was approved by the US Food and Drug Administration in 1975.  In 1997, the rights were sold to Monarch Pharmaceuticals, a division of King Pharmaceuticals.  In 2007, King sold it to JHP Pharmaceuticals.  Par Pharmaceutical acquired JHP in 2014. In 2015, Endo International purchased Par.","wiki_society_and_culture":"== Society and culture ==\n=== Economics ===\nIn 2015, the price was $100, and in 2016, it reportedly was selling for $195. A generic version is priced at $144. The drug is owned by Dublin, Ireland-based Endo International.."},"commercial":{"launchDate":"1957","_launchSource":"DrugCentral (FDA 1957-03-26, MONARCH PHARMS)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4247","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=NEOMYCIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NEOMYCIN","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Neomycin%2Fpolymyxin_B%2Fhydrocortisone","fields":["history","overview"],"source":"Wikipedia"},{"id":5,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T15:05:26.873273","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:39:48.911599+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"hydrogen peroxide","drugSlug":"hydrogen-peroxide","fdaApproval":"","patentExpiry":"Jul 4, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlorhexidine","drugSlug":"chlorhexidine","fdaApproval":"1976-09-17","patentExpiry":"Oct 2, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"amphotericin B","drugSlug":"amphotericin-b","fdaApproval":"1964-11-12","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxyquinoline","drugSlug":"oxyquinoline","fdaApproval":"","relationship":"same-class"},{"drugName":"miconazole","drugSlug":"miconazole","fdaApproval":"1974-01-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"natamycin","drugSlug":"natamycin","fdaApproval":"1978-10-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"tetracycline","drugSlug":"tetracycline","fdaApproval":"1953-11-19","genericCount":34,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"metronidazole","drugSlug":"metronidazole","fdaApproval":"1963-07-18","patentExpiry":"Oct 4, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlortetracycline","drugSlug":"chlortetracycline","fdaApproval":"1950-01-23","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"doxycycline","drugSlug":"doxycycline","fdaApproval":"1967-12-05","patentExpiry":"Dec 19, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"minocycline","drugSlug":"minocycline","fdaApproval":"1971-06-30","patentExpiry":"Sep 8, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"oxytetracycline","drugSlug":"oxytetracycline","fdaApproval":"1964-09-08","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://data.medicaid.gov/dataset/4j6z-xnwq","name":"CMS National Average Drug Acquisition Cost (NADAC)","fields":["pricing"],"retrievedDate":"2026-04-07"}],"genericName":"neomycin","indications":{"approved":[{"name":"Bacterial keratitis","source":"DrugCentral","snomedId":314557000,"regulator":"FDA","eligibility":null,"usPrevalence":null,"globalPrevalence":6000000,"prevalenceMethod":"curated","prevalenceSource":"Cochrane Database Syst Rev, 2025 (PMID:40728038)"},{"name":"Blepharoconjunctivitis","source":"DrugCentral","snomedId":68659002,"regulator":"FDA","eligibility":null},{"name":"Corneal abrasion","source":"DrugCentral","snomedId":85848002,"regulator":"FDA","eligibility":null},{"name":"Hepatic coma","source":"DrugCentral","snomedId":72836002,"regulator":"FDA","eligibility":null},{"name":"Hepatic encephalopathy","source":"DrugCentral","snomedId":13920009,"regulator":"FDA","eligibility":null},{"name":"Infective blepharitis","source":"DrugCentral","snomedId":312219000,"regulator":"FDA","eligibility":null},{"name":"Keratitis","source":"DrugCentral","snomedId":5888003,"regulator":"FDA","eligibility":null,"usPrevalence":null,"globalPrevalence":6000000,"prevalenceMethod":"curated","prevalenceSource":"Cochrane Database Syst Rev, 2025 (PMID:40728038)"},{"name":"Mastoidectomy Cavity Infections","source":"DrugCentral","snomedId":"","regulator":"FDA","eligibility":null},{"name":"Minor Bacterial Skin Infections","source":"DrugCentral","snomedId":"","regulator":"FDA","eligibility":null},{"name":"Minor Skin Wound Pain","source":"DrugCentral","snomedId":"","regulator":"FDA","eligibility":"Patients with minor cuts, scrapes, burns."},{"name":"Otitis externa","source":"DrugCentral","snomedId":3135009,"regulator":"FDA"},{"name":"Preoperative Bowel Preparation","source":"DrugCentral","snomedId":"","regulator":"FDA"},{"name":"Superficial Ocular Infection","source":"DrugCentral","snomedId":"","regulator":"FDA","usPrevalence":null,"globalPrevalence":6000000,"prevalenceMethod":"curated","prevalenceSource":"Cochrane Database Syst Rev, 2025 (PMID:40728038)"},{"name":"Urinary tract infectious disease","source":"DrugCentral","snomedId":68566005,"regulator":"FDA"},{"name":"Uveitis","source":"DrugCentral","snomedId":128473001,"regulator":"FDA"}],"offLabel":[{"name":"Bacterial conjunctivitis","source":"DrugCentral","drugName":"NEOMYCIN","evidenceCount":56,"evidenceLevel":"strong"},{"name":"Chronic purulent otitis media","source":"DrugCentral","drugName":"NEOMYCIN","evidenceCount":34,"evidenceLevel":"moderate"}],"pipeline":[]},"drugCategory":"established","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"hydrogen-peroxide","brandName":"hydrogen peroxide","genericName":"hydrogen peroxide","approvalYear":"","relationship":"same-class"},{"drugId":"chlorhexidine","brandName":"chlorhexidine","genericName":"chlorhexidine","approvalYear":"1976","relationship":"same-class"},{"drugId":"amphotericin-b","brandName":"amphotericin B","genericName":"amphotericin B","approvalYear":"1964","relationship":"same-class"},{"drugId":"oxyquinoline","brandName":"oxyquinoline","genericName":"oxyquinoline","approvalYear":"","relationship":"same-class"},{"drugId":"miconazole","brandName":"miconazole","genericName":"miconazole","approvalYear":"1974","relationship":"same-class"},{"drugId":"natamycin","brandName":"natamycin","genericName":"natamycin","approvalYear":"1978","relationship":"same-class"},{"drugId":"tetracycline","brandName":"tetracycline","genericName":"tetracycline","approvalYear":"1953","relationship":"same-class"},{"drugId":"metronidazole","brandName":"metronidazole","genericName":"metronidazole","approvalYear":"1963","relationship":"same-class"},{"drugId":"clotrimazole","brandName":"clotrimazole","genericName":"clotrimazole","approvalYear":"1975","relationship":"same-class"},{"drugId":"chlortetracycline","brandName":"chlortetracycline","genericName":"chlortetracycline","approvalYear":"1950","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07490054","phase":"PHASE1","title":"Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure","status":"RECRUITING","sponsor":"Melana Yuzefpolskaya, MD","startDate":"2025-09-01","conditions":["Chronic Heart Failure"],"enrollment":40,"completionDate":"2026-11"},{"nctId":"NCT01731236","phase":"EARLY_PHASE1","title":"CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2011-02-11","conditions":["Dietary Modification"],"enrollment":100,"completionDate":"2029-12"},{"nctId":"NCT03663504","phase":"PHASE4","title":"Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ottawa Hospital Research Institute","startDate":"2018-10-23","conditions":["Elective Colon Surgery"],"enrollment":630,"completionDate":"2026-07"},{"nctId":"NCT07017946","phase":"PHASE1,PHASE2","title":"Intestinal Microbiome Transplant in ALS","status":"RECRUITING","sponsor":"Duke University","startDate":"2026-01-27","conditions":["Amyotrophic Lateral Sclerosis ALS"],"enrollment":20,"completionDate":"2026-11-01"},{"nctId":"NCT04729322","phase":"PHASE2","title":"Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2021-02-22","conditions":["Metastatic Colorectal Adenocarcinoma","Metastatic Small Intestinal Adenocarcinoma","Stage IV Colorectal Cancer AJCC v8","Stage IV Small Intestinal Adenocarcinoma AJCC v8","Stage IVA Colorectal Cancer AJCC v8","Stage IVB Colorectal Cancer AJCC v8","Stage IVC Colorectal Cancer AJCC 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