{"id":"nelfinavir-nfv","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Diarrhea"},{"rate":"5-10","effect":"Nausea"},{"rate":"1-3","effect":"Rash"},{"rate":"null","effect":"Hyperglycemia"},{"rate":"null","effect":"Lipid abnormalities"}]},"_chembl":{"chemblId":"CHEMBL584","moleculeType":"Small molecule","molecularWeight":"567.80"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nelfinavir binds to the active site of HIV protease, a viral enzyme essential for processing precursor proteins into functional structural and enzymatic proteins. By inhibiting this protease, the drug prevents the formation of mature, infectious viral particles, thereby reducing viral replication and slowing disease progression. It is typically used as part of combination antiretroviral therapy (cART) in HIV-infected patients.","oneSentence":"Nelfinavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:50:20.155Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV-1 infection (in combination antiretroviral therapy)"},{"name":"Pediatric HIV-1 infection"}]},"trialDetails":[{"nctId":"NCT02016924","phase":"PHASE2, PHASE3","title":"Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV","status":"ACTIVE_NOT_RECRUITING","sponsor":"Gilead Sciences","startDate":"2014-01-16","conditions":"Acquired Immune Deficiency Syndrome (AIDS), HIV Infections","enrollment":133},{"nctId":"NCT03256916","phase":"PHASE3","title":"Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix","status":"COMPLETED","sponsor":"Tata Memorial Hospital","startDate":"2018-01-16","conditions":"Carcinoma Cervix,Stage III","enrollment":348},{"nctId":"NCT07281781","phase":"PHASE1, PHASE2","title":"Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow","status":"RECRUITING","sponsor":"University of California, Irvine","startDate":"2025-09-16","conditions":"Myelofibrosis, Myelofibrosis; Anemia","enrollment":10},{"nctId":"NCT06971744","phase":"PHASE2","title":"Autophagy Maintenance (AUTOMAIN)","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2025-12-18","conditions":"Ovarian Cancer","enrollment":38},{"nctId":"NCT03077451","phase":"PHASE2","title":"Nelfinavir Mesylate in Treating Patients With Kaposi Sarcoma","status":"COMPLETED","sponsor":"AIDS Malignancy Consortium","startDate":"2017-03-13","conditions":"Recurrent Kaposi Sarcoma, Skin Kaposi Sarcoma","enrollment":36},{"nctId":"NCT00042289","phase":"","title":"Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2003-06-09","conditions":"HIV Infections","enrollment":1578},{"nctId":"NCT04169763","phase":"PHASE1","title":"Nelfinavir, Cisplatin, and External Beam Radiation Therapy for the Treatment of Locally Advanced Vulvar Cancer That Cannot Be Removed by Surgery","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2020-08-07","conditions":"Stage II Vulvar Cancer AJCC v8, Stage III Vulvar Cancer AJCC v8, Stage IIIA Vulvar Cancer AJCC v8","enrollment":25},{"nctId":"NCT05502341","phase":"PHASE2, PHASE3","title":"Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen","status":"ACTIVE_NOT_RECRUITING","sponsor":"Gilead Sciences","startDate":"2022-08-16","conditions":"HIV-1-infection","enrollment":689},{"nctId":"NCT05036226","phase":"PHASE1, PHASE2","title":"COAST Therapy in Advanced Solid Tumors and Prostate Cancer","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2022-03-03","conditions":"Prostate Cancer Recurrent, Solid Tumor, Adult","enrollment":76},{"nctId":"NCT00146380","phase":"PHASE2","title":"A Study of Zidovudine/Lamivudine and Either Nevirapine or Nelfinavir for Reduction of Mother-to-child HIV Transmission During Breastfeeding","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2003-07","conditions":"HIV Infections","enrollment":520},{"nctId":"NCT00476606","phase":"","title":"A Prospective Cohort of Children With HIV Infection","status":"COMPLETED","sponsor":"The HIV Netherlands Australia Thailand Research Collaboration","startDate":"2003-03","conditions":"HIV Infections","enrollment":500},{"nctId":"NCT03829020","phase":"PHASE1","title":"Metformin, Nelfinavir, and Bortezomib in Treating Patients With Relapsed and/or Refractory Multiple Myeloma","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2019-04-17","conditions":"Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma","enrollment":9},{"nctId":"NCT02024009","phase":"PHASE1, PHASE2","title":"Systemic Therapy and Chemoradiation in Advanced Localised Pancreatic Cancer - 2","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2016-03","conditions":"Pancreatic Neoplasms (Locally Advanced Non-metastatic)","enrollment":159},{"nctId":"NCT01959672","phase":"PHASE2","title":"Chemotherapy, Stereotactic Body Radiation Therapy & Nelfinavir Mesylate in Locally Advanced Pancreatic Cancer","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2013-09-06","conditions":"Pancreatic Adenocarcinoma, Resectable Pancreatic Carcinoma, Stage I Pancreatic Cancer","enrollment":11},{"nctId":"NCT01068327","phase":"PHASE1","title":"Stereotactic Radiation, Nelfinavir Mesylate & Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2007-11-05","conditions":"Adenocarcinoma of the Pancreas, Stage III Pancreatic Cancer","enrollment":46},{"nctId":"NCT02207439","phase":"PHASE2","title":"Phase II Trial of Nelfinavir With Concurrent Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck","status":"COMPLETED","sponsor":"Abramson Cancer Center at Penn Medicine","startDate":"2014-07","conditions":"Head and Neck Squamous Cell Carcinoma","enrollment":18},{"nctId":"NCT00003008","phase":"PHASE2","title":"Paclitaxel in Treating Patients With AIDS-Related Kaposi's Sarcoma","status":"COMPLETED","sponsor":"Eastern Cooperative Oncology Group","startDate":"1997-12-15","conditions":"Sarcoma","enrollment":33},{"nctId":"NCT01555281","phase":"PHASE1, PHASE2","title":"Nelfinavir and Lenalidomide/Dexamethasone in Progressive Multiple Myeloma","status":"TERMINATED","sponsor":"Swiss Cancer Institute","startDate":"2012-02-23","conditions":"Multiple Myeloma","enrollment":33},{"nctId":"NCT03050060","phase":"PHASE2","title":"Image Guided Hypofractionated Radiation Therapy, Nelfinavir Mesylate, Pembrolizumab, Nivolumab and Atezolizumab in Treating Patients With Advanced Melanoma, Lung, or Kidney Cancer","status":"TERMINATED","sponsor":"University of Washington","startDate":"2017-06-09","conditions":"Metastatic Kidney Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage IV Cutaneous Melanoma AJCC v6 and v7","enrollment":21},{"nctId":"NCT00039741","phase":"PHASE2, PHASE3","title":"Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2002-08","conditions":"HIV Infections","enrollment":266},{"nctId":"NCT00000872","phase":"PHASE2","title":"Treatment With Combinations of Several Antiviral Drugs in Infants and Young Children With HIV Infection","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":55},{"nctId":"NCT00000892","phase":"NA","title":"A Study of Several Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Used Indinavir","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":300},{"nctId":"NCT00001091","phase":"PHASE1","title":"Safety and Effectiveness of Four Anti-HIV Drug Combinations in HIV-Infected Children and Teens","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":200},{"nctId":"NCT00017719","phase":"PHASE3","title":"Combination Treatment With and Without Protease Inhibitors for Women Who Begin Therapy for HIV Infection During Pregnancy","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2002-05","conditions":"HIV Infections, Pregnancy","enrollment":440},{"nctId":"NCT00001108","phase":"PHASE1","title":"A Study of the Safety and Effectiveness of Treating Advanced AIDS Patients Between Ages 4 and 22 With 7 Drugs, Some at Higher Than Usual Doses","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":6},{"nctId":"NCT00001087","phase":"PHASE2","title":"The Effectiveness of Nelfinavir and Efavirenz, Used Alone or Together, Combined With Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":300},{"nctId":"NCT00005762","phase":"NA","title":"Drug Interactions of Amprenavir and Efavirenz, in Combination With a Second Protease Inhibitor, in HIV-Negative Volunteers","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2001-03","conditions":"HIV Infections","enrollment":90},{"nctId":"NCT00001133","phase":"PHASE1","title":"Safety and Tolerance of Indinavir Plus Ritonavir in HIV-Positive Patients Failing Therapy With Amprenavir, Nelfinavir, or Saquinavir","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":50},{"nctId":"NCT00000859","phase":"NA","title":"A Randomized Trial of the Efficacy and Safety of a Strategy of Starting With Nelfinavir Versus Ritonavir Added to Background Antiretroviral (AR) Nucleoside Therapy in HIV-Infected Individuals With CD4+ Cell Counts Less Than or Equal to 200/mm3","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":1300},{"nctId":"NCT00000898","phase":"NA","title":"The Effects of Staggered Dosing on Interactions Between Paired Combinations of Nelfinavir, Ritonavir, and Saquinavir","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":18},{"nctId":"NCT00000914","phase":"NA","title":"A Study of the Effectiveness of Different Anti-HIV Treatments in HIV-Positive Individuals Who Have Been on a Protease Inhibitor-Containing Drug Regimen for at Least 16 Weeks","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":800},{"nctId":"NCT00000913","phase":"PHASE2","title":"A Study to Compare Two Anti-HIV Combination Therapies Each Containing Saquinavir in HIV-Positive Children","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":50},{"nctId":"NCT00000924","phase":"PHASE2","title":"A Study to Compare Two Different Anti-HIV Drug Regimens","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":120},{"nctId":"NCT00000941","phase":"PHASE1","title":"A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":56},{"nctId":"NCT00000902","phase":"PHASE1","title":"A Study on the Management of Combination Anti-HIV Drug Therapy in HIV-Positive Children With Prior Treatment","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":217},{"nctId":"NCT00000912","phase":"PHASE2","title":"A Study on Amprenavir in Combination With Other Anti-HIV Drugs in HIV-Positive Patients","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":475},{"nctId":"NCT00000887","phase":"PHASE1","title":"A Study to Evaluate the Safety and Tolerance of Nelfinavir (NFV) Given With Zidovudine (ZDV) and Lamivudine (3TC) in HIV-Positive Pregnant Women and Their Infants","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections, Pregnancy","enrollment":24},{"nctId":"NCT00000899","phase":"PHASE1","title":"A Study on the Effect of Chemotherapy Combined With Anti-HIV Drugs in HIV-Positive Patients","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":10},{"nctId":"NCT00000893","phase":"PHASE1","title":"Safety, Tolerability, and Anti-HIV Activity of DMP 266 (Efavirenz) in Combination With Nelfinavir in HIV-Positive Children","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"1997-10","conditions":"HIV Infections","enrollment":103},{"nctId":"NCT00000895","phase":"NA","title":"A Study to Learn More About MAC Disease and the Use of Anti-HIV Drugs in Patients With Advanced HIV Infection","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"Mycobacterium Avium-intracellulare Infection, HIV Infections","enrollment":85},{"nctId":"NCT00000885","phase":"PHASE2","title":"Treatment Success and Failure in HIV-Infected Subjects Receiving Indinavir in Combination With Nucleoside Analogs: A Rollover Study for ACTG 320","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":440},{"nctId":"NCT03631732","phase":"PHASE3","title":"Study to Evaluate Switching From a Regimen of Two Nucleos(t)Ide Reverse Transcriptase Inhibitors (NRTI) Plus a Third Agent to a Fixed Dose Combination (FDC) of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF), in Virologically-Suppressed, HIV-1 Infected African American Participants","status":"COMPLETED","sponsor":"Gilead Sciences","startDate":"2018-08-28","conditions":"HIV-1 Infection","enrollment":496},{"nctId":"NCT01728779","phase":"PHASE2","title":"Stereotactic Body Radiation With Nelfinavir for Oligometastases","status":"COMPLETED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins","startDate":"2014-01-08","conditions":"Oligometastases","enrollment":38},{"nctId":"NCT01108666","phase":"PHASE2","title":"Proton Beam Radiation With Concurrent Chemotherapy and Nelfinavir for Inoperable Stage III Non Small Cell Lung Cancer (NSCLC)","status":"TERMINATED","sponsor":"Abramson Cancer Center at Penn Medicine","startDate":"2010-03","conditions":"Non Small Cell Lung Cancer","enrollment":7},{"nctId":"NCT01925378","phase":"PHASE2","title":"A Phase II Single-arm Intervention Trial of Nelfinavir in Patients With Grade 2/3 or 3 Cervical Intraepithelial Neoplasia","status":"WITHDRAWN","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2018-11-07","conditions":"Cervical Dysplasia","enrollment":""},{"nctId":"NCT00589056","phase":"PHASE1, PHASE2","title":"Nelfinavir, Radiation Therapy, Cisplatin, and Etoposide in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery","status":"COMPLETED","sponsor":"Abramson Cancer Center at Penn Medicine","startDate":"2007-06","conditions":"Lung Cancer","enrollment":55},{"nctId":"NCT02363829","phase":"PHASE1","title":"A Study of Nelfinavir Added to Cisplatin Chemotherapy Concurrent With Pelvic Radiation for Locally Advanced Cervical Cancer (II-IVA)","status":"COMPLETED","sponsor":"Abramson Cancer Center at Penn Medicine","startDate":"2015-02","conditions":"Uterine Cervix Cancer","enrollment":6},{"nctId":"NCT02066311","phase":"PHASE2","title":"Nelfinavir in Systemic Lupus Erythematosus","status":"TERMINATED","sponsor":"Northwell Health","startDate":"2014-09","conditions":"Systemic Lupus Erythematosus","enrollment":15},{"nctId":"NCT01445106","phase":"PHASE1","title":"A Phase I Trial of Nelfinavir (Viracept ) in Adults With Solid Tumors","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2006-12-11","conditions":"Solid Tumors","enrollment":28},{"nctId":"NCT00307502","phase":"PHASE1","title":"Study to Determine the Pharmacokinetic Behavior of Antiretroviral Drugs in Patients Infected by HIV","status":"COMPLETED","sponsor":"Germans Trias i Pujol Hospital","startDate":"2005-01","conditions":"HIV Infections","enrollment":675},{"nctId":"NCT01065844","phase":"PHASE2","title":"Nelfinavir in Recurrent Adenoid Cystic Cancer of the Head and Neck","status":"COMPLETED","sponsor":"University of Iowa","startDate":"2009-10","conditions":"Carcinoma, Adenoid Cystic, Head and Neck Neoplasms","enrollment":15},{"nctId":"NCT00457665","phase":"PHASE4","title":"Mechanisms of Lipodystrophy in HIV-Infected Pateints","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2002-02","conditions":"HIV Infections","enrollment":56},{"nctId":"NCT02188537","phase":"PHASE2","title":"Nelfinavir as Bortezomib-sensitizing Drug in Patients With Proteasome Inhibitor-nonresponsive Myeloma","status":"COMPLETED","sponsor":"Swiss Cancer Institute","startDate":"2014-12-02","conditions":"Myeloma","enrollment":34},{"nctId":"NCT01164709","phase":"PHASE1","title":"Nelfinavir Mesylate and Bortezomib in Treating Patients With Relapsed or Progressive Advanced Hematologic Cancer","status":"COMPLETED","sponsor":"Swiss Cancer Institute","startDate":"2010-07","conditions":"Leukemia, Lymphoma, Mature T-cell and Nk-cell Neoplasms","enrollment":18},{"nctId":"NCT00915694","phase":"PHASE1","title":"Nelfinavir Mesylate, Radiation Therapy, and Temozolomide in Treating Patients With Glioblastoma Multiforme","status":"TERMINATED","sponsor":"Abramson Cancer Center at Penn Medicine","startDate":"2009-04","conditions":"Brain and Central Nervous System Tumors","enrollment":15},{"nctId":"NCT01020292","phase":"PHASE1","title":"A Trial of the Protease Inhibitor Nelfinavir and Concurrent Radiation and Temozolomide in Patients With WHO Grade IV Glioma","status":"COMPLETED","sponsor":"Abramson Cancer Center at Penn Medicine","startDate":"2009-04","conditions":"Glioma","enrollment":31},{"nctId":"NCT00205283","phase":"NA","title":"Nelfinavir and M8 Drug-level Monitoring in HIV-1 Infection","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2003-08","conditions":"HIV Infections","enrollment":20},{"nctId":"NCT01086332","phase":"PHASE1","title":"Evaluation of Nelfinavir and Chemoradiation for Pancreatic Cancer","status":"TERMINATED","sponsor":"University of Iowa","startDate":"2009-05","conditions":"Pancreatic Neoplasms","enrollment":7},{"nctId":"NCT03422874","phase":"PHASE1","title":"Dose Escalation Study of Nelfinavir Plus MLN9708 in Patients With Advanced Solid Tumors or Lymphoma","status":"WITHDRAWN","sponsor":"Dartmouth-Hitchcock Medical Center","startDate":"2016-08","conditions":"Neoplasms, Lymphoma","enrollment":""},{"nctId":"NCT00791336","phase":"PHASE2","title":"Study to Evaluate Using Nelfinavir With Chemoradiation for Non-small Cell Lung Cancer","status":"TERMINATED","sponsor":"University of Iowa","startDate":"2008-08","conditions":"Carcinoma, Non-Small-Cell Lung","enrollment":1},{"nctId":"NCT01814722","phase":"","title":"Quality of Life of HIV-infected Participants Switched to Raltegravir Versus Other Antiretroviral Regimens (MK-0518-266)","status":"TERMINATED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2012-11-09","conditions":"Human Immunodeficiency Virus","enrollment":63},{"nctId":"NCT00541463","phase":"PHASE2","title":"A Study of Indinavir Plus Ritonavir Plus Two NRTIs vs. Nelfinavir Plus Two NRTIs in HIV Positive Patients (0639-112)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2001-01","conditions":"HIV Infections","enrollment":330},{"nctId":"NCT01447589","phase":"PHASE1, PHASE2","title":"Radical Lung Radiotherapy Plus Nelfinavir","status":"WITHDRAWN","sponsor":"Oxford University Hospitals NHS Trust","startDate":"2012-02","conditions":"Lung Cancer","enrollment":""},{"nctId":"NCT02080416","phase":"EARLY_PHASE1","title":"Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors","status":"TERMINATED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins","startDate":"2014-07","conditions":"Non-Hodgkin Lymphoma, Hodgkin Lymphoma, Kaposi Sarcoma","enrollment":1},{"nctId":"NCT00445146","phase":"PHASE2","title":"Safety of EVG+RTV Administered With Other Antiretroviral Agents for the Treatment of HIV-1 Infection","status":"COMPLETED","sponsor":"Gilead Sciences","startDate":"2007-02","conditions":"HIV Infections","enrollment":192},{"nctId":"NCT00044837","phase":"PHASE1","title":"Hormone Replacement Therapy and Anti-HIV Drugs in HIV-Infected, Postmenopausal Women","status":"TERMINATED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":120},{"nctId":"NCT01485731","phase":"PHASE1","title":"Safety Study of Nelfinavir + Cisplatin + Pelvic Radiation Therapy to Treat Cervical Cancer","status":"COMPLETED","sponsor":"University of Miami","startDate":"2012-01","conditions":"Cervical Cancer","enrollment":8},{"nctId":"NCT00385450","phase":"PHASE1","title":"Cardiopulmonary Bypass-Induced Lymphocytopenia and the Potential Effects of Protease Inhibitor","status":"TERMINATED","sponsor":"Mayo Clinic","startDate":"2006-10","conditions":"Cardiopulmonary Bypass","enrollment":41},{"nctId":"NCT00694837","phase":"PHASE1","title":"Study With Nelfinavir and Combined Radiochemotherapy for Glioblastoma","status":"COMPLETED","sponsor":"Maastricht Radiation Oncology","startDate":"2009-03","conditions":"Glioblastoma","enrollment":6},{"nctId":"NCT00233948","phase":"PHASE1, PHASE2","title":"Nelfinavir Mesylate in Treating Patients With Recurrent, Metastatic, or Unresectable Liposarcoma","status":"TERMINATED","sponsor":"City of Hope Medical Center","startDate":"2006-03","conditions":"Adult Liposarcoma, Recurrent Adult Soft Tissue Sarcoma, Stage III Adult Soft Tissue Sarcoma","enrollment":29},{"nctId":"NCT00006441","phase":"NA","title":"Effectiveness of Adding Interleukin-2 to Anti-HIV Drugs in Patients Recently Infected With HIV","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2003-02","conditions":"HIV Infections","enrollment":398},{"nctId":"NCT00001094","phase":"PHASE2","title":"A Comparison of Nelfinavir Plus Saquinavir Plus Delavirdine or 3TC/ZDV Versus Nelfinavir Plus 3TC/ZDV in HIV-Infected Patients","status":"WITHDRAWN","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":""},{"nctId":"NCT00704600","phase":"PHASE1, PHASE2","title":"Nelfinavir, a Phase I/Phase II Rectal Cancer Study","status":"COMPLETED","sponsor":"Maastricht Radiation Oncology","startDate":"2008-09","conditions":"Colorectal Cancer, Colorectal Carcinoma, Colorectal Tumors","enrollment":15},{"nctId":"NCT02257008","phase":"PHASE1","title":"Effect of Different Boosting Agents on Pharmacokinetics of BILR 355 BS Dissolved in Polyethylene Glycol 400 (PEG 400) in Healthy Male Volunteers","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2003-03","conditions":"Healthy","enrollment":44},{"nctId":"NCT00624195","phase":"PHASE2, PHASE3","title":"Clinical Trial of CNS-targeted HAART (CIT2)","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2007-03","conditions":"HIV Infections","enrollment":59},{"nctId":"NCT00000922","phase":"NA","title":"A Study to Evaluate the Long-Term Effectiveness of Three Anti-HIV Drug Regimens in HIV Infected Patients Who Have Never Been Exposed to Highly Active Antiretroviral Therapy (HAART)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":1710},{"nctId":"NCT00234091","phase":"PHASE3","title":"When to Start Anti-HIV Drugs in Children Infected With HIV (The PREDICT Study)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2006-04","conditions":"HIV Infections","enrollment":300},{"nctId":"NCT01079286","phase":"PHASE1","title":"Study of Nelfinavir and Temsirolimus in Patients With Advanced Cancers","status":"COMPLETED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2009-06","conditions":"Renal Cell Cancer, Cancer","enrollment":18},{"nctId":"NCT00099359","phase":"PHASE3","title":"Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission","status":"COMPLETED","sponsor":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","startDate":"2004-02","conditions":"Disease Transmission, Vertical, Vertical Human Immunodeficiency Virus Transmission, HIV Infections","enrollment":1735},{"nctId":"NCT00016601","phase":"NA","title":"Depo-Medroxyprogesterone Acetate (DMPA, Depo-Provera) Use With Certain Anti-HIV Drugs in HIV-Infected Women","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2001-06","conditions":"HIV Infections","enrollment":76},{"nctId":"NCT00041964","phase":"","title":"A Study of HIV Levels During Pregnancy and After Childbirth","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections, Pregnancy","enrollment":129},{"nctId":"NCT00000919","phase":"NA","title":"A Study to Evaluate Various Combinations of Anti-HIV Medications to Treat Early HIV Infection","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":900},{"nctId":"NCT00000903","phase":"PHASE3","title":"Addition of Efavirenz or Nelfinavir to a Lamivudine/Zidovudine/Indinavir HIV Treatment Regimen","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":444},{"nctId":"NCT00000918","phase":"PHASE2","title":"A Study to Compare The Ability of Different Anti-HIV Drugs to Decrease Viral Load After Nelfinavir (an Anti-HIV Drug)Treatment Failure","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":300},{"nctId":"NCT00192660","phase":"PHASE4","title":"HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001)","status":"COMPLETED","sponsor":"Kirby Institute","startDate":"2003-02","conditions":"HIV-Associated Lipodystrophy Syndrome, Cardiovascular Disease","enrollment":80},{"nctId":"NCT00650637","phase":"PHASE3","title":"A Study to Determine Effective Prophylaxis and Treatment of Nelfinavir-Associated Diarrhea","status":"TERMINATED","sponsor":"Pfizer","startDate":"2003-01","conditions":"Diarrhea","enrollment":17},{"nctId":"NCT00141284","phase":"PHASE4","title":"An Open Label Study To Evaluate The Safety and Kinetics of Nelfinavir in Subjects With HIV and Hepatitis C","status":"COMPLETED","sponsor":"Pfizer","startDate":"2005-10","conditions":"HIV Infection, Hepatitis C","enrollment":12},{"nctId":"NCT00051844","phase":"PHASE2","title":"Capravirine (AG1549) in Combination With Viracept and Two NRTIs in HIV Infected Patients Who Failed an Initial NNRTI Containing Regimen","status":"COMPLETED","sponsor":"Pfizer","startDate":"2002-08","conditions":"Human Immunodeficiency Virus","enrollment":179},{"nctId":"NCT00002240","phase":"PHASE2","title":"Study of a New Protease Inhibitor, BMS-232632, in Combination With Other Anti-HIV Drugs","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"1999-03","conditions":"HIV Infections","enrollment":""},{"nctId":"NCT00028067","phase":"PHASE3","title":"A Comparison of Atazanavir and Nelfinavir, Each in Combination With 2 NRTIs, in Patients Who Have Failed Treatments Without a Protease Inhibitor","status":"TERMINATED","sponsor":"Bristol-Myers Squibb","startDate":"2001-08","conditions":"HIV Infections","enrollment":500},{"nctId":"NCT00002429","phase":"PHASE3","title":"Evaluation of an Anti-HIV Drug Combination That Includes a Coated Form of Didanosine (ddI EC) Compared to a Typical Anti-HIV Drug Regimen","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"1999-07","conditions":"HIV Infections","enrollment":500},{"nctId":"NCT00246610","phase":"PHASE4","title":"Safety Of VIRACEPT® 625mg Administered To HIV-Infected Women During Pregnancy","status":"COMPLETED","sponsor":"Pfizer","startDate":"2006-03","conditions":"HIV Infection","enrollment":16},{"nctId":"NCT00002224","phase":"PHASE3","title":"Comparison of Two Anti-HIV Regimens That Include One of Two Forms of Didanosine (ddI)","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"1999-03","conditions":"HIV Infections","enrollment":120},{"nctId":"NCT00002411","phase":"NA","title":"A Comparison of Two Triple-Drug Combinations in Patients Who Have Never Been Treated With Anti-HIV Drugs","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"1998-03","conditions":"HIV Infections","enrollment":""},{"nctId":"NCT00002177","phase":"NA","title":"A Pilot Open Label Trial of HIV Therapy With d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects With Recent HIV Infection","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"1997-05","conditions":"HIV Infections","enrollment":""},{"nctId":"NCT00002176","phase":"NA","title":"A Pilot Open Label Trial of HIV Therapy With d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects With Early Asymptomatic HIV Infection","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"1997-05","conditions":"HIV Infections","enrollment":""},{"nctId":"NCT00346580","phase":"PHASE1","title":"The Effects of HIV Protease Inhibitors in Severe Sepsis","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2003-06","conditions":"Sepsis","enrollment":60},{"nctId":"NCT00006443","phase":"NA","title":"Effectiveness of Anti-HIV Drugs in Patients Who Have Not Received Previous Anti-HIV Drugs During Different Stages of HIV Infection","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":24},{"nctId":"NCT00028327","phase":"PHASE3","title":"Potent Antiviral Therapy for Critically Ill HIV Infected Patients Admitted to Intensive Care","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":250},{"nctId":"NCT00001122","phase":"PHASE2","title":"A Study of an Adherence Plan to Help HIV-Positive Patients Take Their First Anti-HIV Medications Correctly","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"HIV Infections","enrollment":74}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"FOETAL EXPOSURE DURING PREGNANCY"},{"count":2,"reaction":"HIV INFECTION"},{"count":2,"reaction":"HUMAN IMMUNODEFICIENCY VIRUS TRANSMISSION"},{"count":1,"reaction":"CAESAREAN SECTION"},{"count":1,"reaction":"DRUG RESISTANCE"}],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Viracept"],"phase":"phase_3","status":"active","brandName":"Nelfinavir (NFV)","genericName":"Nelfinavir (NFV)","companyName":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","companyId":"eunice-kennedy-shriver-national-institute-of-child-health-and-human-development","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nelfinavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles. Used for HIV-1 infection (in combination antiretroviral therapy), Pediatric HIV-1 infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}