{"id":"nelarabine-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Neurotoxicity (peripheral neuropathy, seizures)"},{"rate":null,"effect":"Myelosuppression (anemia, thrombocytopenia, neutropenia)"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Infection"}]},"_chembl":{"chemblId":"CHEMBL1201112","moleculeType":"Small molecule","molecularWeight":"297.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nelarabine is a purine analog prodrug that is metabolized to arabinosyl guanine (ara-G), which accumulates in T-lymphoid cells and inhibits ribonucleotide reductase, disrupting deoxyribonucleotide synthesis. This leads to depletion of deoxyadenosine triphosphate pools and triggers apoptosis in T-cell leukemias and lymphomas. The drug is particularly effective in T-cell malignancies due to high levels of deoxycytidine kinase in these cells.","oneSentence":"Nelarabine is a prodrug that is converted to arabinosyl guanine, which inhibits ribonucleotide reductase and DNA synthesis, leading to apoptosis in T-cell malignancies.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:45.535Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"T-cell acute lymphoblastic leukemia (T-ALL)"},{"name":"T-cell lymphoblastic lymphoma (T-LBL)"}]},"trialDetails":[{"nctId":"NCT03117751","phase":"PHASE2, PHASE3","title":"Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Jude Children's Research Hospital","startDate":"2017-03-29","conditions":"Acute Lymphoblastic Leukemia, Acute Lymphoblastic Lymphoma","enrollment":790},{"nctId":"NCT06434467","phase":"PHASE3","title":"The Efficacy and Safety of Nelarabine Injection in Patients With T-lymphoblastic Leukemia and T-lymphoblastic Lymphoma","status":"NOT_YET_RECRUITING","sponsor":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","startDate":"2024-05","conditions":"T-lymphoblastic Leukemia, T-lymphoblastic Lymphoma","enrollment":83},{"nctId":"NCT02518750","phase":"PHASE2","title":"Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma","status":"TERMINATED","sponsor":"St. Jude Children's Research Hospital","startDate":"2016-11-23","conditions":"Acute Lymphoblastic Leukemia, Lymphoma, Non-Hodgkin's, Leukemia, T-Cell","enrollment":3},{"nctId":"NCT00406757","phase":"PHASE1","title":"Clinical Evaluation of Nelarabine (506U78)in Japanese Patients With Leukemia or Lymphoma","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-08-30","conditions":"Leukaemia, Lymphoblastic, Acute and Lymphoma, Lymphoblastic","enrollment":13},{"nctId":"NCT01376115","phase":"","title":"Drug Use Investigation for ARRANON G (Nelarabine) Injection 250mg","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2008-01-18","conditions":"Cancer","enrollment":343}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Nelarabine injection","genericName":"Nelarabine injection","companyName":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","companyId":"chia-tai-tianqing-pharmaceutical-group-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nelarabine injection is a small molecule DNA inhibitor used to treat various types of cancer, including T-lymphoblastic leukemia and lymphoma, as well as non-Hodgkin's lymphoma. It is administered as a 250mg injection, often in combination with dexamethasone.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}