{"id":"nefopam-administration-and-prelevment","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Sweating"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL465026","moleculeType":"Small molecule","molecularWeight":"253.35"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nefopam works by blocking the reuptake of catecholamines and serotonin at nerve terminals, increasing their synaptic concentration and enhancing pain modulation pathways. Unlike opioids, it does not bind to opioid receptors and has a different mechanism of action, making it useful as an alternative or adjunctive analgesic. It is commonly used perioperatively and for moderate pain management.","oneSentence":"Nefopam is a non-opioid analgesic that inhibits the reuptake of monoamines (norepinephrine, dopamine, and serotonin) in the central nervous system to produce analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:57.558Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate acute pain (perioperative and postoperative pain management)"},{"name":"Moderate chronic pain"}]},"trialDetails":[{"nctId":"NCT07491393","phase":"PHASE4","title":"Pharmacokinetic Study of the Use of Nefopam 30 mg Tablets in Patients Suffering From Acute Pain in Rheumatology","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Rouen","startDate":"2026-04-01","conditions":"Acute Rheumatic Pain","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Nefopam administration and prelevment","genericName":"Nefopam administration and prelevment","companyName":"University Hospital, Rouen","companyId":"university-hospital-rouen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nefopam is a non-opioid analgesic that inhibits the reuptake of monoamines (norepinephrine, dopamine, and serotonin) in the central nervous system to produce analgesia. Used for Postoperative pain, Acute pain management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}