{"id":"nefiracetam","rwe":[],"tags":[{"label":"nefiracetam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Neuroprotective Agents","category":"pharmacology"},{"label":"Nootropic Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"translon","offLabel":[],"synonyms":["DM-9384","DM 9384","nefiracetam","translon"],"timeline":[],"approvals":[],"brandName":"Translon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"nefiracetam","explanation":"Imagine your brain is a busy city with many different streets and intersections. Nefiracetam helps to improve communication between the different areas of the city by making the streets (neurotransmitters) work more efficiently. This can help to improve memory, learning, and other cognitive functions.","oneSentence":"Nefiracetam is a nootropic agent that works by enhancing the activity of neurotransmitters in the brain.","technicalDetail":"Nefiracetam is a pyrrolidone derivative that acts as a positive allosteric modulator of AMPA receptors, increasing the release of glutamate and other neurotransmitters, and enhancing synaptic plasticity."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3376","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=NEFIRACETAM","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NEFIRACETAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:08:52.212605","biosimilars":[],"competitors":[],"genericName":"nefiracetam","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00001933","phase":"PHASE2","title":"Nefiracetam in the Treatment of Alzheimer's Disease","status":"COMPLETED","sponsor":"National Institute of Neurological Disorders and Stroke (NINDS)","startDate":"1999-07","conditions":["Alzheimer's Disease"],"enrollment":50,"completionDate":"2002-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"1JK12GX30N","CHEBI":"CHEBI:135004","INN_ID":"6710","UMLSCUI":"C0165264","ChEMBL_ID":"CHEMBL260829","DRUGBANK_ID":"DB13082","PUBCHEM_CID":"71157","MESH_SUPPLEMENTAL_RECORD_UI":"C058876"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":133,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nefiracetam is a small molecule. It is also known by the synonyms NEFIRACETAM, NEFIRACETAM, NEFIRACETAM, NEFIRACETAM, and NSC-759830.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}