{"id":"nebulized-lidocaine-and-dexmedetomidine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Local airway irritation"}]},"_chembl":{"chemblId":"CHEMBL2106195","moleculeType":"Small molecule","molecularWeight":"236.75"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine blocks sodium channels in nerve fibers, numbing the respiratory tract to reduce cough and airway discomfort. Dexmedetomidine binds to alpha-2 adrenergic receptors in the central nervous system, producing sedation, analgesia, and anxiolysis while maintaining airway reflexes. The combination is used to facilitate airway procedures and reduce patient discomfort during intubation or bronchoscopy.","oneSentence":"Nebulized lidocaine provides local anesthesia of the airway while dexmedetomidine acts as a selective alpha-2 adrenergic agonist to produce sedation and analgesia.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:56:51.490Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Airway anesthesia and sedation for intubation procedures"},{"name":"Sedation and analgesia during bronchoscopy and airway instrumentation"}]},"trialDetails":[{"nctId":"NCT06607861","phase":"EARLY_PHASE1","title":"Nebulized Dexmedetomidine or Lidocaine for Treatment of Post Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia","status":"NOT_YET_RECRUITING","sponsor":"Minia University","startDate":"2024-10-01","conditions":"Pain Score (VAS)","enrollment":114},{"nctId":"NCT06470854","phase":"NA","title":"Effect of Nebulized Dexmedetomidine on Post-dural Puncture Headache","status":"COMPLETED","sponsor":"Tanta University","startDate":"2023-11-01","conditions":"Post-Dural Puncture Headache","enrollment":50},{"nctId":"NCT05941767","phase":"NA","title":"Dexmedetomidine or Lidocaine for Lessening the Hemodynamic Responses to Laryngoscopy and Intubation","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2023-07-12","conditions":"Anesthesia Intubation Complication","enrollment":100},{"nctId":"NCT06088875","phase":"NA","title":"Nebulization Versus Spray-as-You-Go Airway Topical Anesthesia Using Dexmedetomidine and Lidocaine Mixture During Awake Flexible Fiberoptic Intubation in Temporomandibular Ankylosis","status":"UNKNOWN","sponsor":"Tanta University","startDate":"2023-10-18","conditions":"Nebulization, Spray-as-You-Go, Dexmedetomidine","enrollment":50},{"nctId":"NCT05158348","phase":"PHASE3","title":"A Comparative Study to Measure the Effect of Nebulized Dexmedetomidine","status":"UNKNOWN","sponsor":"Kasr El Aini Hospital","startDate":"2021-11-05","conditions":"Dexmedetomidine, Lidocaine, Tonsillectomy","enrollment":60},{"nctId":"NCT04659057","phase":"PHASE4","title":"Nebulized Lidocaine, Dexmedetomedine and Their Combination in Direct Laryngoscopy Surgery","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2020-12-12","conditions":"Hemodynamic Instability","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Combined lidocaine and dexmedetomidine group"],"phase":"marketed","status":"active","brandName":"Nebulized lidocaine and dexmedetomidine","genericName":"Nebulized lidocaine and dexmedetomidine","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nebulized lidocaine provides local anesthesia of the airway while dexmedetomidine acts as a selective alpha-2 adrenergic agonist to produce sedation and analgesia. Used for Airway anesthesia and sedation for intubation procedures, Sedation and analgesia during bronchoscopy and airway manipulation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}