{"id":"nebulized-epinephrine-and-nebulized-albuterol","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Nervousness or anxiety"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Epinephrine is a non-selective adrenergic agonist that stimulates alpha and beta receptors, causing vasoconstriction and bronchodilation to reduce airway edema and mucus production. Albuterol is a selective beta-2 adrenergic agonist that directly relaxes bronchial smooth muscle. Together, this combination provides rapid relief of airway obstruction through complementary mechanisms of action.","oneSentence":"Nebulized epinephrine and albuterol work synergistically as bronchodilators and decongestants to rapidly open airways and reduce airway inflammation and edema.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:56:51.777Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Croup (laryngotracheobronchitis)"},{"name":"Acute airway obstruction"},{"name":"Bronchospasm"}]},"trialDetails":[{"nctId":"NCT01229384","phase":"NA","title":"Randomized Controlled Trial Comparing Standard Versus Positive Pressure Nebulization in Infants With Bronchiolitis to Reduce Hospital Admissions","status":"WITHDRAWN","sponsor":"Phoenix Children's Hospital","startDate":"2011-10","conditions":"Bronchiolitis","enrollment":""},{"nctId":"NCT05667727","phase":"PHASE4","title":"The Effect of Nebulized Epinephrine in Asthma Exacerbation in Pediatric Age Group With the Standard Treatment Compared to Standard Treatment Using Improvement PRAM Score as a Primary Outcome","status":"COMPLETED","sponsor":"Oman Medical Speciality Board","startDate":"2023-10-15","conditions":"Shortness of Breath, Asthma in Children, Epinephrine Causing Adverse Effects in Therapeutic Use","enrollment":30},{"nctId":"NCT03219736","phase":"NA","title":"NiPPV in the Treatment of Acute Asthma Exacerbations","status":"WITHDRAWN","sponsor":"Arkansas Children's Hospital Research Institute","startDate":"2017-06-01","conditions":"Bronchial Asthma, Status Asthmaticus","enrollment":""},{"nctId":"NCT00361452","phase":"PHASE4","title":"Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study","status":"TERMINATED","sponsor":"Rambam Health Care Campus","startDate":"2000-12","conditions":"Rsv Bronchiolitis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":17,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"nebulized epinephrine and nebulized albuterol","genericName":"nebulized epinephrine and nebulized albuterol","companyName":"Rambam Health Care Campus","companyId":"rambam-health-care-campus","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nebulized epinephrine and albuterol work synergistically as bronchodilators and decongestants to rapidly open airways and reduce airway inflammation and edema. Used for Croup (laryngotracheobronchitis), Acute airway obstruction, Bronchospasm.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}