{"id":"nebulized-epinephrine","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Nervousness or anxiety"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Rebound airway obstruction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Epinephrine acts on alpha-1 adrenergic receptors in the airway mucosa to cause vasoconstriction, reducing submucosal edema and airway obstruction. Simultaneously, it stimulates beta-2 adrenergic receptors on bronchial smooth muscle to promote bronchodilation. The nebulized delivery targets the upper and lower airways directly, providing rapid symptomatic relief in acute airway obstruction.","oneSentence":"Nebulized epinephrine is an inhaled alpha and beta-adrenergic agonist that rapidly constricts airway blood vessels and relaxes bronchial smooth muscle to reduce airway edema and improve airflow.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:34:59.988Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Croup (laryngotracheobronchitis) in children"},{"name":"Acute upper airway obstruction"},{"name":"Laryngeal edema"}]},"trialDetails":[{"nctId":"NCT05440851","phase":"NA","title":"Platform of Randomized Adaptive Clinical Trials in Critical Illness","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2023-04-30","conditions":"Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High","enrollment":6250},{"nctId":"NCT01229384","phase":"NA","title":"Randomized Controlled Trial Comparing Standard Versus Positive Pressure Nebulization in Infants With Bronchiolitis to Reduce Hospital Admissions","status":"WITHDRAWN","sponsor":"Phoenix Children's Hospital","startDate":"2011-10","conditions":"Bronchiolitis","enrollment":""},{"nctId":"NCT03567473","phase":"PHASE3","title":"Bronchiolitis in Infants Placebo Versus Epinephrine and Dexamethasone Study","status":"COMPLETED","sponsor":"Children's Hospital of Eastern Ontario","startDate":"2018-12-13","conditions":"Bronchiolitis","enrollment":864},{"nctId":"NCT05667727","phase":"PHASE4","title":"The Effect of Nebulized Epinephrine in Asthma Exacerbation in Pediatric Age Group With the Standard Treatment Compared to Standard Treatment Using Improvement PRAM Score as a Primary Outcome","status":"COMPLETED","sponsor":"Oman Medical Speciality Board","startDate":"2023-10-15","conditions":"Shortness of Breath, Asthma in Children, Epinephrine Causing Adverse Effects in Therapeutic Use","enrollment":30},{"nctId":"NCT06267118","phase":"PHASE3","title":"Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis","status":"RECRUITING","sponsor":"Combined Military Hospital, Pakistan","startDate":"2023-11-01","conditions":"Acute Bronchiolitis Due to Respiratory Syncytial Virus","enrollment":60},{"nctId":"NCT03219736","phase":"NA","title":"NiPPV in the Treatment of Acute Asthma Exacerbations","status":"WITHDRAWN","sponsor":"Arkansas Children's Hospital Research Institute","startDate":"2017-06-01","conditions":"Bronchial Asthma, Status Asthmaticus","enrollment":""},{"nctId":"NCT05738564","phase":"PHASE3","title":"Epinephrine Nebulization Prior to Nasotracheal Intubation","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-09-01","conditions":"Nasal Bleeding","enrollment":126},{"nctId":"NCT05639127","phase":"EARLY_PHASE1","title":"The Treatment of Adrenal Crisis With Inhaled Prednisolone","status":"UNKNOWN","sponsor":"University Medical Center Groningen","startDate":"2022-11-03","conditions":"Adrenal Insufficiency","enrollment":12},{"nctId":"NCT03814954","phase":"NA","title":"Nebulized Epinephrine vs. Salbutamol in Bronchiolitis Among Children","status":"COMPLETED","sponsor":"Makassed General Hospital","startDate":"2019-01-01","conditions":"Respiratory Distress Score","enrollment":90},{"nctId":"NCT05006235","phase":"PHASE1","title":"Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn (TTN)","status":"COMPLETED","sponsor":"Ahmed Noaman","startDate":"2014-02-01","conditions":"Transient Tachypnea of the Newborn","enrollment":135},{"nctId":"NCT03614273","phase":"NA","title":"Nebulized Hypertonic Saline (3%) Versus Nebulized Adrenaline for Treatment of Bronchiolitis","status":"COMPLETED","sponsor":"Maulana Azad Medical College","startDate":"2015-03-01","conditions":"Bronchiolitis","enrollment":60},{"nctId":"NCT01664507","phase":"PHASE4","title":"The Effect and Safety of Low Dose Nebulized Epinephrine in Croup","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2016-01","conditions":"Croup, Epinephrine, Administration, Inhalation","enrollment":84},{"nctId":"NCT01660867","phase":"PHASE4","title":"Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department","status":"WITHDRAWN","sponsor":"Seoul National University Hospital","startDate":"2012-08","conditions":"Acute Bronchiolitis","enrollment":""},{"nctId":"NCT02586961","phase":"PHASE2, PHASE3","title":"Nebulized Adrenalin and Oral Betamethasone in Children With Bronchiolitis Attending Pediatric Emergencies.","status":"TERMINATED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2015-10","conditions":"Children, Bronchiolitis","enrollment":195},{"nctId":"NCT02724761","phase":"NA","title":"Prophylactic Racemic Epinephrine in Anterior Cervical Discectomy and Fusion","status":"UNKNOWN","sponsor":"Andrew Chung","startDate":"2016-09","conditions":"Dysphagia, Dysphonia, Postoperative Pain","enrollment":90},{"nctId":"NCT02585531","phase":"PHASE2","title":"Epinephrine, Dexamethasone and Hypertonic Saline in Bronchiolitis","status":"UNKNOWN","sponsor":"Hospital General Naval de Alta Especialidad - Escuela Medico Naval","startDate":"2015-11","conditions":"Bronchiolitis","enrollment":100},{"nctId":"NCT01834820","phase":"PHASE4","title":"Epinephrine, Dexamethasone, and Hypertonic Saline in Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety","status":"COMPLETED","sponsor":"Hospital General Naval de Alta Especialidad - Escuela Medico Naval","startDate":"2013-01","conditions":"Bronchiolitis","enrollment":120},{"nctId":"NCT02056379","phase":"NA","title":"Comparison Between Budesonide and Dexamethasone Treatments for Respiratory Discomfort After Extubation on Children","status":"UNKNOWN","sponsor":"Hospital Israelita Albert Einstein","startDate":"2014-03","conditions":"Stridor","enrollment":70},{"nctId":"NCT01873144","phase":"PHASE3","title":"High Flow Therapy vs Hypertonic Saline in Bronchiolitis","status":"COMPLETED","sponsor":"Ministry of Health, Spain","startDate":"2010-10","conditions":"Acute Viral Bronchiolitis","enrollment":75},{"nctId":"NCT00961233","phase":"NA","title":"Topical Budesonide Treatment for Eosinophilic Esophagitis (EoE)","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2009-10","conditions":"Eosinophilic Esophagitis","enrollment":25},{"nctId":"NCT01216553","phase":"PHASE4","title":"Home Oxygen Therapy in Bronchiolitis","status":"UNKNOWN","sponsor":"Meir Medical Center","startDate":"2011-10","conditions":"Bronchiolitis","enrollment":135},{"nctId":"NCT01300325","phase":"PHASE4","title":"Effectiveness of Nebulized Hypertonic Saline and Epinephrine in Hospitalized Infants With Bronchiolitis","status":"COMPLETED","sponsor":"Federico II University","startDate":"2008-11","conditions":"Bronchiolitis","enrollment":136},{"nctId":"NCT01016249","phase":"PHASE4","title":"Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis","status":"COMPLETED","sponsor":"Hamad Medical Corporation","startDate":"2007-04","conditions":"Bronchiolitis","enrollment":187},{"nctId":"NCT00361452","phase":"PHASE4","title":"Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study","status":"TERMINATED","sponsor":"Rambam Health Care Campus","startDate":"2000-12","conditions":"Rsv Bronchiolitis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":102,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Nebulized Adrenaline"],"phase":"marketed","status":"active","brandName":"nebulized epinephrine","genericName":"nebulized epinephrine","companyName":"Oman Medical Speciality Board","companyId":"oman-medical-speciality-board","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nebulized epinephrine is a small molecule adrenergic receptor agonist used to treat conditions such as RSV bronchiolitis, bronchiolitis, and acute bronchiolitis. It is administered via nebulization, a method of delivering medication directly to the lungs, and is often compared to nebulized albuterol in clinical trials.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}