{"id":"nebulised-bupivacaine-intraperitoneally","safety":{"commonSideEffects":[{"rate":null,"effect":"Local tissue irritation"},{"rate":null,"effect":"Systemic bupivacaine toxicity (if absorbed)"},{"rate":null,"effect":"Peritoneal inflammation"}]},"_chembl":{"chemblId":"CHEMBL1098","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a long-acting local anesthetic that blocks sodium channels in nerve fibers, inhibiting pain signal transmission. When nebulised and delivered intraperitoneally during or after abdominal surgery, it achieves high local concentrations at visceral and parietal peritoneal surfaces, reducing acute postoperative pain without systemic absorption. This approach aims to minimize opioid requirements and improve recovery outcomes.","oneSentence":"Nebulised bupivacaine delivered intraperitoneally provides local anesthetic effect to reduce postoperative pain and inflammation within the peritoneal cavity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:50:19.996Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain reduction following abdominal surgery"}]},"trialDetails":[{"nctId":"NCT00180687","phase":"PHASE3","title":"Clinical Trial of the Use of Intraperitoneal Local Anaesthetic","status":"COMPLETED","sponsor":"Imperial College London","startDate":"2004-10","conditions":"Pain, Postoperative","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Marcaine"],"phase":"phase_3","status":"active","brandName":"Nebulised Bupivacaine intraperitoneally","genericName":"Nebulised Bupivacaine intraperitoneally","companyName":"Imperial College London","companyId":"imperial-college-london","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nebulised bupivacaine delivered intraperitoneally provides local anesthetic effect to reduce postoperative pain and inflammation within the peritoneal cavity. Used for Postoperative pain reduction following abdominal surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}