{"id":"nebivolol-valsartan-combination","safety":{"commonSideEffects":[{"rate":"null","effect":"Dizziness"},{"rate":"null","effect":"Headache"},{"rate":"null","effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL434394","moleculeType":"Small molecule","molecularWeight":"405.44"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Nebivolol is a beta-blocker that inhibits the effects of epinephrine, leading to vasodilation and decreased cardiac output. Valsartan is an angiotensin II receptor antagonist that blocks the action of angiotensin II, a potent vasoconstrictor, to lower blood pressure. This combination of mechanisms allows for a synergistic effect in lowering blood pressure.","oneSentence":"Nebivolol/valsartan combination works by blocking the effects of the hormone epinephrine and relaxing blood vessels, while valsartan blocks the action of angiotensin II, a potent vasoconstrictor, to lower blood pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:42.565Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT05170061","phase":"PHASE3","title":"24 Hour Ambulatory Cardiac Oxygen Consumption","status":"COMPLETED","sponsor":"State University of New York at Buffalo","startDate":"2013-02","conditions":"Hypertension","enrollment":26},{"nctId":"NCT06035978","phase":"PHASE4","title":"Determination of Drug Levels for Pharmacotherapy of Heart Failure","status":"NOT_YET_RECRUITING","sponsor":"University Hospital Ostrava","startDate":"2024-03","conditions":"Cardiovascular Diseases, Heart Failure With Reduced Ejection Fraction","enrollment":100},{"nctId":"NCT04575675","phase":"PHASE4","title":"Dapagliflozin on Hypotensive Heart Failure Patients After Sacubitril/Valsartan Therapy","status":"COMPLETED","sponsor":"Cheng-Hsin General Hospital","startDate":"2020-05-29","conditions":"Hypotension, Heart Failure","enrollment":78},{"nctId":"NCT02200822","phase":"PHASE4","title":"Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients","status":"COMPLETED","sponsor":"Hasselt University","startDate":"2014-07","conditions":"Heart Failure (HF)","enrollment":80},{"nctId":"NCT01508026","phase":"PHASE3","title":"Study of the Efficacy and Safety of the Combination of Two FDA Approved Oral Medications, Nebivolol and Valsartan for Treatment of Stage 1 or 2 Hypertension","status":"COMPLETED","sponsor":"Forest Laboratories","startDate":"2012-01","conditions":"Stage 1 Hypertension, Stage 2 Hypertension","enrollment":4161},{"nctId":"NCT01415505","phase":"PHASE3","title":"Combination of Nebivolol and Valsartan Given as Free Tablets for Stage 1 or Stage 2 Hypertension","status":"COMPLETED","sponsor":"Forest Laboratories","startDate":"2011-08","conditions":"Hypertension","enrollment":812},{"nctId":"NCT00295542","phase":"PHASE4","title":"Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy","status":"COMPLETED","sponsor":"University of Vigo","startDate":"2000-03","conditions":"Hypertension","enrollment":3344}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Diovan/Bystolic"],"phase":"phase_3","status":"active","brandName":"Nebivolol/valsartan combination","genericName":"Nebivolol/valsartan combination","companyName":"State University of New York at Buffalo","companyId":"state-university-of-new-york-at-buffalo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nebivolol/valsartan combination works by blocking the effects of the hormone epinephrine and relaxing blood vessels, while valsartan blocks the action of angiotensin II, a potent vasoconstrictor, to lower blood pressure. Used for Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}