{"id":"nb","safety":{"commonSideEffects":[{"rate":"30–40","effect":"Nausea"},{"rate":"20–25","effect":"Constipation"},{"rate":"15–20","effect":"Headache"},{"rate":"10–15","effect":"Dizziness"},{"rate":"10–15","effect":"Vomiting"},{"rate":"10–12","effect":"Insomnia"},{"rate":"8–10","effect":"Dry mouth"}]},"_chembl":null,"_dailymed":{"setId":"d5ceabf2-43a0-4746-9371-d98a39cf6cfc","title":"LOARGYS (PEGZILARGINASE-NBLN) INJECTION [IMMEDICA PHARMA US INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Naltrexone blocks opioid receptors in the hypothalamus, removing tonic inhibition of pro-opiomelanocortin (POMC) neurons that regulate appetite. Bupropion, an atypical antidepressant, inhibits reuptake of norepinephrine and dopamine, further enhancing satiety signaling and metabolic rate. 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