{"id":"nature-s-tears","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild ocular irritation"},{"rate":null,"effect":"Temporary blurred vision"},{"rate":null,"effect":"Eye discomfort"}]},"_chembl":{"chemblId":"CHEMBL1790520","moleculeType":"Protein","molecularWeight":"1422.72"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This product is a topical ophthalmic lubricant formulated to mimic natural tear composition and provide sustained moisture to the cornea and conjunctiva. It reduces friction between the eyelid and eye surface, alleviating discomfort associated with dry eye disease. The solution helps restore the tear film and protect the ocular surface from further irritation.","oneSentence":"Nature's Tears is an artificial tear solution that lubricates and moisturizes the ocular surface to relieve dry eye symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:42.753Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease / Keratoconjunctivitis sicca"}]},"trialDetails":[{"nctId":"NCT06933381","phase":"NA","title":"Vapocoolant Spray to Reduce Pain With Nexplanon Insertion","status":"RECRUITING","sponsor":"Queen's Medical Center","startDate":"2025-06-16","conditions":"Reducing Pain With Nexplanon Implant Insertion","enrollment":70},{"nctId":"NCT01670487","phase":"NA","title":"Vapocoolant (Pain Ease Medium Stream) for Intravenous Lines in Emergency Department Patients","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2012-10","conditions":"Pain","enrollment":300},{"nctId":"NCT01712776","phase":"NA","title":"Vapocoolant (Pain Ease) Use for Venipuncture","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2011-04","conditions":"Pain","enrollment":100},{"nctId":"NCT04635696","phase":"PHASE4","title":"Ethyl Chloride for NPWT","status":"COMPLETED","sponsor":"ProMedica Health System","startDate":"2019-01-07","conditions":"Pain, Acute","enrollment":100},{"nctId":"NCT03054740","phase":"PHASE4","title":"Vapocoolant Spray Used Prior to Intravenous (IV) Insertions","status":"COMPLETED","sponsor":"Aultman Health Foundation","startDate":"2017-02-27","conditions":"Pain","enrollment":30},{"nctId":"NCT02499965","phase":"NA","title":"Skin Refrigerant to Reduce the Pain Associated With IV Insertion","status":"COMPLETED","sponsor":"Brooke Army Medical Center","startDate":"2015-04","conditions":"Pain","enrollment":38},{"nctId":"NCT01091714","phase":"PHASE4","title":"Is Omega-3 Fatty Acid Red Blood Cell (RBC) Saturation Product Dependent?","status":"COMPLETED","sponsor":"Bucci Laser Vision Institute","startDate":"2010-10","conditions":"Cardioprotective Levels","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1585,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sterile Water"],"phase":"marketed","status":"active","brandName":"Nature's Tears","genericName":"Nature's Tears","companyName":"Aultman Health Foundation","companyId":"aultman-health-foundation","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nature's Tears is an over-the-counter artificial tear solution that lubricates and moisturizes the ocular surface to relieve dry eye symptoms. Used for Dry eye syndrome / Keratoconjunctivitis sicca, Ocular irritation and discomfort.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}