{"id":"natural-saline-inhalation","safety":{"commonSideEffects":[{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Bronchospasm (rare, in sensitive patients)"}]},"_chembl":{"chemblId":"CHEMBL2108783","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Inhaled saline acts as a mucolytic and hydrating agent that increases airway surface liquid, reduces mucus viscosity, and promotes clearance of secretions through coughing and mucociliary transport. This mechanical action helps relieve airway obstruction and improve ventilation without pharmacological receptor targeting.","oneSentence":"Natural saline inhalation delivers isotonic sodium chloride solution via aerosol to hydrate and clear respiratory secretions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:44.432Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Airway secretion clearance and hydration in respiratory conditions"},{"name":"Symptomatic relief of cough and airway congestion"}]},"trialDetails":[{"nctId":"NCT07489950","phase":"NA","title":"Non-apnea Saline-contrast EIT for Lung Perfusion Imaging in Spontaneously Breathing Patients: A Prospective Cross-over Study","status":"COMPLETED","sponsor":"Ruijin Hospital","startDate":"2026-01-10","conditions":"Pulmonary Perfusion, Ventilation-Perfusion Ratio, Respiratory Insufficiency","enrollment":24},{"nctId":"NCT06514040","phase":"NA","title":"Nebulized Dexmedetomidine Versus Oral Sumatriptan in Treatment of Post Dural Puncture Headache in Cesarean Section","status":"COMPLETED","sponsor":"Fayoum University Hospital","startDate":"2023-11-27","conditions":"Post-Dural Puncture Headache","enrollment":48},{"nctId":"NCT06093191","phase":"PHASE4","title":"Tobramycin Inhalation Solution for Pseudomonas Aeruginosa Eradication in Bronchiectasis","status":"RECRUITING","sponsor":"Shanghai Pulmonary Hospital, Shanghai, China","startDate":"2023-09-25","conditions":"Bronchiectasis Adult, Pseudomonas Aeruginosa Infection","enrollment":364},{"nctId":"NCT05478902","phase":"NA","title":"Effectiveness of Non-surgical Management in Rotator Cuff Calcific Tendinopathy (THE EFFECT TRIAL)","status":"UNKNOWN","sponsor":"University of Valencia","startDate":"2023-05-01","conditions":"Rotator Cuff Tendinosis, Rotator Cuff Injuries, Shoulder Tendinitis","enrollment":116},{"nctId":"NCT06133868","phase":"NA","title":"The Efficacy of Lavender and Chamomile Essential Oils Inhalation in Management of Dental Anxiety and Pain in Children Undergoing Local Anesthesia Administration and Primary Tooth Extraction","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-12-01","conditions":"Anxiety, Dental","enrollment":60},{"nctId":"NCT03757572","phase":"NA","title":"Alginate Dressings Versus Gauge Dressings After Pilonidal Cyst Resection: Examination of the Quality of Life","status":"TERMINATED","sponsor":"Larissa University Hospital","startDate":"2018-12-25","conditions":"Pilonidal Cyst/Fistula","enrollment":65},{"nctId":"NCT04747574","phase":"PHASE1","title":"Evaluation of the Safety of CD24-Exosomes in Patients With COVID-19 Infection","status":"UNKNOWN","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2020-09-25","conditions":"SARS-CoV-2","enrollment":35},{"nctId":"NCT03715322","phase":"PHASE3","title":"Tobramycin in Bronchiectasis Colonized With Pseudmonas Aeruginosa","status":"UNKNOWN","sponsor":"Guangzhou Institute of Respiratory Disease","startDate":"2018-10-26","conditions":"Bronchiectasis Adult, Pseudomonas Infections","enrollment":350},{"nctId":"NCT01574885","phase":"PHASE2","title":"Efficacy of Aerosal® in the Treatment of Sub-Obstructive Adenotonsillar Hypertrophy and Related Diseases","status":"TERMINATED","sponsor":"Tecno Sun SRL","startDate":"2012-02","conditions":"Sleep Apnea, Obstructive","enrollment":45}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Inhaled saline"],"phase":"marketed","status":"active","brandName":"Natural saline inhalation","genericName":"Natural saline inhalation","companyName":"Shanghai Pulmonary Hospital, Shanghai, China","companyId":"shanghai-pulmonary-hospital-shanghai-china","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Natural saline inhalation delivers isotonic sodium chloride solution via aerosol to hydrate and clear respiratory secretions. Used for Airway secretion clearance and mucus mobilization in respiratory conditions, Supportive care for patients with excessive or thick airway secretions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}