{"id":"natural-aloe-vera","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or contact dermatitis"},{"rate":null,"effect":"Gastrointestinal cramping (oral use)"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":{"chemblId":"CHEMBL2108221","moleculeType":"Unknown"},"_dailymed":{"setId":"a2dc3cf4-23d2-4cb7-8fdc-615420db5710","title":"THAYERS SINCE 1847 NATURAL REMEDIES BLEMISH CLEARING WITCH HAZEL ALOE VERA FORMULA TONER (SALICYLIC ACID) LIQUID [L'OREAL USA PRODUCTS INC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aloe vera's gel contains acemannan and other polysaccharides that stimulate fibroblast activity and collagen synthesis, accelerating tissue repair. Its anthraquinones and phenolic compounds exhibit anti-inflammatory and antimicrobial properties. When used topically, it hydrates and soothes damaged skin; when ingested, it may have laxative and digestive benefits, though systemic mechanisms are less well-characterized.","oneSentence":"Aloe vera contains polysaccharides and bioactive compounds that promote wound healing, reduce inflammation, and provide antimicrobial effects when applied topically or ingested.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T05:17:22.166Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical wound healing and minor burns"},{"name":"Skin irritation and inflammation"},{"name":"Constipation (oral formulation)"}]},"trialDetails":[{"nctId":"NCT06984848","phase":"NA","title":"Effect of Enzymatic-Containing Mouth Spray (Oral7®) on Xerostomia Symptoms, Salivary Flow Rate, and Oral Health-Related Quality of Life in Older Patients","status":"NOT_YET_RECRUITING","sponsor":"ZAINAB MAT YUDIN","startDate":"2025-08-01","conditions":"Xerostomia, Geriatric","enrollment":100},{"nctId":"NCT04964167","phase":"PHASE4","title":"Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis","status":"COMPLETED","sponsor":"Riyadh Elm University","startDate":"2021-09-07","conditions":"Periodontitis, Periodontal Inflammation","enrollment":150},{"nctId":"NCT04252209","phase":"PHASE3","title":"the Effect of Mixture of Natural Products As Salivary Substitutes in Treatment Of Xerostomia","status":"COMPLETED","sponsor":"Cairo University","startDate":"2021-03-22","conditions":"Sjogren's Syndrome, Xerostomia","enrollment":24},{"nctId":"NCT05738733","phase":"NA","title":"A Clinical Efficacy Study of MsChief Personal Lubricant in Healthy Female Subjects","status":"COMPLETED","sponsor":"NovoBliss Research Pvt Ltd","startDate":"2023-03-02","conditions":"Healthy Females","enrollment":138},{"nctId":"NCT05862519","phase":"NA","title":"A Clinical Study to Evaluate the Efficacy of Four Supplements on Improving Readiness for Intimacy","status":"UNKNOWN","sponsor":"906 CMVI Holdings","startDate":"2023-03-14","conditions":"Libido, Intimacy, Gastrointestinal Issues","enrollment":36},{"nctId":"NCT03401749","phase":"PHASE4","title":"Preadmission Skin Wipe Use for Surgical Site Infection Prophylaxis in Adult Orthopaedic Surgery Patients","status":"TERMINATED","sponsor":"University of Alabama at Birmingham","startDate":"2018-11-01","conditions":"Surgical Site Infection","enrollment":203},{"nctId":"NCT03934762","phase":"NA","title":"Aloe Vera Ointment Application and Skeletal Muscle Recovery","status":"COMPLETED","sponsor":"University of Thessaly","startDate":"2019-04-25","conditions":"Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation, Performance","enrollment":10},{"nctId":"NCT03301844","phase":"NA","title":"To Compare Blephapad Combo vs Standard Treatment for Eyelid Cleansing in Bilateral Posterior Blepharitis","status":"COMPLETED","sponsor":"NTC srl","startDate":"2017-05-15","conditions":"Bilateral Blepharitis (Disorder)","enrollment":19},{"nctId":"NCT02837107","phase":"NA","title":"Study of Supplement's Antioxidant Properties That Contains Natural Extracts","status":"UNKNOWN","sponsor":"Harokopio University","startDate":"2013-09","conditions":"Healthy","enrollment":62}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Natural Aloe Vera","genericName":"Natural Aloe Vera","companyName":"University of Thessaly","companyId":"university-of-thessaly","modality":"Biologic","firstApprovalDate":"","aiSummary":"Aloe vera contains polysaccharides and compounds that promote wound healing, reduce inflammation, and provide antimicrobial effects when applied topically or ingested. Used for Topical wound healing and minor burns, Oral use for gastrointestinal health and constipation relief, Skin irritation and inflammatory skin conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}