{"id":"natto-extract-nattokinase","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding or increased bleeding risk"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nattokinase, derived from fermented soybeans (natto), is a fibrinolytic enzyme that breaks down fibrin, the primary structural component of blood clots. It works through direct fibrinolysis and may also enhance the body's endogenous fibrinolytic system by increasing plasmin activity. This mechanism is proposed to improve blood flow and reduce thrombotic risk.","oneSentence":"Nattokinase is a serine protease enzyme that directly degrades fibrin clots and enhances fibrinolysis to promote thrombus dissolution.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:47.769Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thrombotic disorders and cardiovascular disease prevention"},{"name":"Blood clot dissolution and fibrinolysis support"}]},"trialDetails":[{"nctId":"NCT00447434","phase":"PHASE4","title":"Efficacy and Safety of Natto Extract","status":"COMPLETED","sponsor":"Changhua Christian Hospital","startDate":"2005-06","conditions":"Thrombosis, Cardiovascular Diseases","enrollment":45}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":22,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Natto extract (Nattokinase)","genericName":"Natto extract (Nattokinase)","companyName":"Changhua Christian Hospital","companyId":"changhua-christian-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nattokinase is a serine protease enzyme that directly degrades fibrin clots and enhances fibrinolysis to improve blood flow. Used for Thrombosis prevention and management, Cardiovascular health and blood flow improvement, Post-thrombotic syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}