{"id":"natesto-testosterone-nasal-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation or discomfort"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Rhinitis"},{"rate":null,"effect":"Epistaxis"},{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Polycythemia"}]},"_chembl":{"chemblId":"CHEMBL1200335","moleculeType":"Small molecule","molecularWeight":"400.60"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Testosterone is a naturally occurring androgen hormone that binds to androgen receptors throughout the body to promote male sexual characteristics, muscle development, bone density, and overall metabolic function. NATESTO is a nasal gel formulation that allows testosterone to be absorbed through the nasal mucosa, providing systemic hormone replacement therapy. This route of administration offers an alternative to intramuscular injections and transdermal patches for testosterone replacement in hypogonadal men.","oneSentence":"NATESTO delivers testosterone through nasal absorption to replace deficient testosterone in hypogonadal men.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:56:42.439Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Testosterone replacement therapy in adult males with hypogonadism"}]},"trialDetails":[{"nctId":"NCT06130449","phase":"EARLY_PHASE1","title":"Testosterone and Neural Function","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2024-04-01","conditions":"Spinal Cord Injury","enrollment":15},{"nctId":"NCT05381831","phase":"PHASE4","title":"Natesto Spermatogenesis Reboot","status":"COMPLETED","sponsor":"University of Florida","startDate":"2022-06-01","conditions":"Hypogonadism, Male","enrollment":13},{"nctId":"NCT04717362","phase":"EARLY_PHASE1","title":"The Effects of Natesto For Treatment Of Hypogonadism","status":"WITHDRAWN","sponsor":"Baylor College of Medicine","startDate":"2024-03-01","conditions":"Hypogonadism, Male, Infertility, Male, Testosterone Deficiency","enrollment":""},{"nctId":"NCT03345797","phase":"PHASE1","title":"Evaluation of Testosterone Nasal Gel in Hypogonadal Boys","status":"TERMINATED","sponsor":"Acerus Biopharma Inc.","startDate":"2018-03-01","conditions":"Hypogonadism","enrollment":8},{"nctId":"NCT05484167","phase":"PHASE4","title":"Natesto Testosterone Nasal Gel for Hypogonadal Men","status":"WITHDRAWN","sponsor":"University of Utah","startDate":"2023-01-01","conditions":"Erectile Dysfunction, Sexual Dysfunction","enrollment":""},{"nctId":"NCT04976595","phase":"PHASE4","title":"A Study to Monitor Ambulatory Blood Pressure Monitoring in Hypogonadal Men Treated With Nasal Testosterone Gel","status":"UNKNOWN","sponsor":"Acerus Pharmaceuticals Corporation","startDate":"2021-07-01","conditions":"Hypogonadism","enrollment":218},{"nctId":"NCT02937740","phase":"PHASE4","title":"Open-Label Study, Evaluating Patient Satisfaction and Symptom Improvement When Treating Male Hypogonadism With Natesto™","status":"COMPLETED","sponsor":"Acerus Pharmaceuticals Corporation","startDate":"2016-10","conditions":"Hypogonadism","enrollment":117},{"nctId":"NCT03281187","phase":"PHASE3","title":"Efficacy and Safety of Testosterone Nasal Gel for Treating Hypogonadism in Men.","status":"UNKNOWN","sponsor":"FBM Industria Brasileira Ltda","startDate":"2018-07-16","conditions":"Hypogonadism","enrollment":228}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NATESTO"],"phase":"marketed","status":"active","brandName":"NATESTO Testosterone Nasal Gel","genericName":"NATESTO Testosterone Nasal Gel","companyName":"Acerus Pharmaceuticals Corporation","companyId":"acerus-pharmaceuticals-corporation","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NATESTO delivers testosterone through nasal absorption to replace deficient testosterone in hypogonadal men. Used for Testosterone replacement therapy in adult males with hypogonadism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}