{"id":"naropeine","rwe":[],"tags":[],"safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[],"contraindications":["Acute exacerbation of asthma","Alcoholism","Benign intracranial hypertension","Benign prostatic hyperplasia","Bradycardia","Chronic disease of respiratory system","Chronic obstructive lung disease","Cor pulmonale","Decreased cardiac function","Decreased respiratory function","Deficiency of cholinesterase","Disease of liver","Disorder of biliary tract","Disorder of cardiovascular system","Drug AND/OR toxin-induced diarrhea","Inflammatory bowel disease","Injury of head","Kidney disease","Lesion of brain","Myasthenia gravis","Paralytic ileus","Procedure on urinary system","Substance abuse","Urethral stricture"],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"trials":[],"_chembl":null,"aliases":[],"patents":[],"pricing":[],"offLabel":[],"timeline":[],"_dailymed":null,"ecosystem":[],"mechanism":{"target":"Potassium channel subfamily K member 3, Sodium channel protein type 1 subunit alpha, Sodium channel protein type 10 subunit alpha"},"_scrapedAt":"2026-03-28T01:22:41.170Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"references":[],"biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"indications":{"approved":[{"name":"Anesthesia for cesarean section","diseaseId":"anesthesia-for-cesarean-section","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Local anesthesia","diseaseId":"local-anesthesia","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Major Nerve Block for Surgery","diseaseId":"major-nerve-block-for-surgery","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Regional Anesthesia for Labor Pain","diseaseId":"regional-anesthesia-for-labor-pain","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Regional Anesthesia for Postoperative Pain","diseaseId":"regional-anesthesia-for-postoperative-pain","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Regional Anesthesia for Surgery","diseaseId":"regional-anesthesia-for-surgery","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"}],"offLabel":[],"pipeline":[]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06807164","phase":"PHASE2","title":"Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome","status":"RECRUITING","sponsor":"Centre Oscar Lambret","startDate":"2026-03-31","conditions":"Post-Mastectomy Neuropathic Pain Syndrome","enrollment":123},{"nctId":"NCT01999153","phase":"PHASE3","title":"Evaluation of the Analgesic Effect of Ropivacaine in Topical Use at the Thin Skin Graft Donor Site","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2013-12-09","conditions":"Graft Pain","enrollment":58},{"nctId":"NCT02821169","phase":"PHASE3","title":"Infiltration in the Region of the Palatine Ganglion Spheno by Ropivacaine on Postoperative Pain","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2015-04","conditions":"Pain","enrollment":184},{"nctId":"NCT00372268","phase":"NA","title":"Effects of Insufflated Gas on Core Temperature and Post-operative Pain During Laparoscopic Surgery","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2006-01","conditions":"Laparoscopy, Pain, Postoperative, Hypothermia","enrollment":248},{"nctId":"NCT04327063","phase":"PHASE3","title":"MIRs 04 : Interpectoral Nerve Block With Ropivacaine Versus Placebo Before Breast Cancer Surgery","status":"COMPLETED","sponsor":"Institut Curie","startDate":"2020-08-04","conditions":"Malignant Neoplasm of Breast","enrollment":182},{"nctId":"NCT07110857","phase":"NA","title":"Evaluation of the Superficial Cervical Plexus Block in Oncological Throat and Neck Surgery","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-09","conditions":"ENT Cancers","enrollment":346},{"nctId":"NCT06896591","phase":"NA","title":"Deep Posterior Post Gluteal Compartment Block in Total Hip Arthroplasty: Feasability and Safety","status":"NOT_YET_RECRUITING","sponsor":"Quincy Anesthésie","startDate":"2025-06-01","conditions":"Total Hip Arthroplasty","enrollment":35},{"nctId":"NCT05345639","phase":"PHASE3","title":"Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study)","status":"COMPLETED","sponsor":"University Hospital, Angers","startDate":"2022-08-01","conditions":"Pain, Postoperative, Cardiac Surgery","enrollment":254},{"nctId":"NCT05848375","phase":"NA","title":"Rotator Cuff Repair Under Isolated Loco-regional Anesthesia","status":"RECRUITING","sponsor":"Elsan","startDate":"2023-11-13","conditions":"Shoulder Cuff Surgical Repair","enrollment":80},{"nctId":"NCT06200298","phase":"NA","title":"Effectiveness of Erector Spinae Plane Block for Percutaneous Arthrodesis of Spinal Fractures","status":"RECRUITING","sponsor":"University Hospital, Lille","startDate":"2024-04-11","conditions":"SPINAL Fracture, Pain, Postoperative","enrollment":86},{"nctId":"NCT05969457","phase":"PHASE3","title":"Effect of Preventive Analgesia by Injection of a Local Anesthetic Before Vaginal Incision for Hysterectomy by vNOTES Approach","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Rouen","startDate":"2024-05-30","conditions":"Hysterotomy; Affecting Fetus","enrollment":108},{"nctId":"NCT04983836","phase":"NA","title":"Comparison of Analgesic Efficiency Between Serratus Block and Paravertebral Block in Video-assisted Thoracic Surgery. Double-blind Randomized Comparative Non-inferiority Study (BSBP)","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nice","startDate":"2021-12-05","conditions":"Anesthesia","enrollment":150},{"nctId":"NCT04173364","phase":"PHASE3","title":"Interscalene Block and Dysfunction Diaphragmatic","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2019-10-29","conditions":"Diaphragmatic Paralysis","enrollment":60},{"nctId":"NCT02408393","phase":"PHASE3","title":"MIRs03: Paravertebral Block With Ropivacaine Before Breast Cancer Surgery","status":"COMPLETED","sponsor":"Institut Curie","startDate":"2015-03-27","conditions":"Malignant Neoplasm of Breast","enrollment":380},{"nctId":"NCT02857465","phase":"PHASE3","title":"Epidural Dexamethasone for Labor Analgesia: the Effects on Ropivacaine Consumption and Labour Outcome","status":"WITHDRAWN","sponsor":"Centre Hospitalier Universitaire de la Réunion","startDate":"2017-01","conditions":"Obstetric Pain, Other Complications of Obstetric Anesthesia - Delivered","enrollment":""},{"nctId":"NCT02080728","phase":"PHASE4","title":"Transversus Abdominis Plane Block During Kidney Transplant Surgery","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2013-07-23","conditions":"Kidney Transplant","enrollment":50},{"nctId":"NCT01388946","phase":"NA","title":"Analgesia in Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"University of Athens","startDate":"2010-05","conditions":"Pain, Postoperative, Chronic Postoperative Pain","enrollment":110},{"nctId":"NCT02185924","phase":"PHASE2, PHASE3","title":"Combination of Continuous Femoral Block and Intravenous Parecoxib For Postoperative Analgesia After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Asklepieion Voulas General Hospital","startDate":"2009-01","conditions":"POSTOPERATIVE ANALGESIA FOR TKA PARECOXIB/CFB","enrollment":90},{"nctId":"NCT01307215","phase":"NA","title":"TAP Block: Does Volume Make a Difference?","status":"COMPLETED","sponsor":"McMaster University","startDate":"2011-04","conditions":"Post-operative Pain","enrollment":31},{"nctId":"NCT00724685","phase":"PHASE4","title":"Interest of Continuous Ropivacaine Administration Through an Elastomeric Pump (Pain Buster) for the Surgery of Latissimus Dorsi and Serratus Micro Anastomotic Flaps","status":"TERMINATED","sponsor":"Nantes University Hospital","startDate":"2008-01","conditions":"Post Operative Analgesia","enrollment":34},{"nctId":"NCT01558713","phase":"PHASE2, PHASE3","title":"Epidural Volume Extension and Intrathecal Use of Local Anesthetics in Cesarean Sections","status":"UNKNOWN","sponsor":"University of Patras","startDate":"2010-01","conditions":"Stillborn Caesarean Section","enrollment":120},{"nctId":"NCT01582607","phase":"PHASE2, PHASE3","title":"Subarachnoid Administration of Levobupivacaine for Cesarean Section","status":"UNKNOWN","sponsor":"University of Patras","startDate":"2010-01","conditions":"Stillborn Caesarean Section","enrollment":130},{"nctId":"NCT01404377","phase":"PHASE4","title":"Wound Infiltration and Breast Cancer Surgery","status":"COMPLETED","sponsor":"Tenon Hospital, Paris","startDate":"2006-01","conditions":"Breast Cancer","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"formularyStatus":[],"_approvalHistory":[],"developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"companionDiagnostics":[],"genericManufacturerList":[],"phase":"phase_3","status":"active","brandName":"Naropeine","genericName":"Naropeine","companyName":"University Hospital, Rouen","companyId":"university-hospital-rouen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Naropeine is being studied in clinical trials for various conditions, including post-mastectomy neuropathic pain syndrome, diaphragmatic paralysis, breast cancer, hysterotomy, and ENT cancers. The interventions being tested include a capsaicin 8% patch, serratus plane block, and botulinum toxin A.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}