{"id":"naproxen-sodium-codeine-phosphate","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Nausea"},{"rate":"5-15","effect":"Dizziness"},{"rate":"10-25","effect":"Constipation"},{"rate":"5-15","effect":"Dyspepsia"},{"rate":"5-10","effect":"Drowsiness"},{"rate":"1-3","effect":"Gastrointestinal bleeding"},{"rate":"1-5","effect":"Respiratory depression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, reducing prostaglandin synthesis and thereby decreasing inflammation, pain, and fever. Codeine phosphate is an opioid analgesic that binds to mu-opioid receptors in the central nervous system to modulate pain perception. The combination provides synergistic pain relief for moderate to moderately severe pain conditions.","oneSentence":"Naproxen sodium inhibits cyclooxygenase enzymes to reduce inflammation and pain, while codeine phosphate acts as an opioid agonist to enhance analgesia through central nervous system depression.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:38.456Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to moderately severe pain"},{"name":"Acute pain conditions requiring combined NSAID and opioid analgesia"}]},"trialDetails":[{"nctId":"NCT06916234","phase":"PHASE4","title":"Evaluation of the Analgesic Efficacy of the Combination of Dexketoprofen + Paracetamol and the Combination of Naproxen Sodium + Codeine in Patients With Acute Dental Pain","status":"COMPLETED","sponsor":"ibrahim doğru","startDate":"2023-01-10","conditions":"Acute Dental Pain","enrollment":100},{"nctId":"NCT04066426","phase":"PHASE4","title":"Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2018-03-01","conditions":"Temporomandibular Disorder","enrollment":200},{"nctId":"NCT02501564","phase":"PHASE4","title":"Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis","status":"COMPLETED","sponsor":"Istanbul Medeniyet University","startDate":"2013-05","conditions":"Osteoarthritis","enrollment":135},{"nctId":"NCT01952652","phase":"PHASE4","title":"Naproxen Codeine in Arthroscopic Surgery","status":"COMPLETED","sponsor":"Baskent University","startDate":"2013-01","conditions":"Arthroscopic Meniscus Surgery","enrollment":61}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Naproxen Sodium + Codeine Phosphate","genericName":"Naproxen Sodium + Codeine Phosphate","companyName":"ibrahim doğru","companyId":"ibrahim-do-ru","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Naproxen sodium inhibits cyclooxygenase enzymes to reduce inflammation and pain, while codeine phosphate acts as an opioid agonist to enhance analgesia through central nervous system effects. Used for Moderate pain relief, Pain associated with inflammation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}