{"id":"naproxen-sodium-aleve","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Gastrointestinal upset (dyspepsia, nausea)"},{"rate":"5-15","effect":"Abdominal pain"},{"rate":"5-10","effect":"Headache"},{"rate":"3-9","effect":"Dizziness"},{"rate":null,"effect":"Increased cardiovascular risk (with chronic use)"},{"rate":null,"effect":"Renal impairment (with chronic use)"}]},"_chembl":{"chemblId":"CHEMBL1200806","moleculeType":"Small molecule","molecularWeight":"252.25"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that non-selectively blocks COX-1 and COX-2 enzymes. By inhibiting these enzymes, it reduces the synthesis of prostaglandins, which are key mediators of inflammation, pain signaling, and fever. The sodium salt formulation allows for faster absorption and more rapid onset of action compared to standard naproxen.","oneSentence":"Naproxen sodium inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin production, thereby decreasing inflammation, pain, and fever.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:37.469Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever"},{"name":"Inflammation associated with arthritis and musculoskeletal conditions"}]},"trialDetails":[{"nctId":"NCT07493226","phase":"NA","title":"Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis","status":"RECRUITING","sponsor":"Konya Beyhekim Training and Research Hospital","startDate":"2026-04-01","conditions":"Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain","enrollment":120},{"nctId":"NCT05430230","phase":"PHASE4","title":"Study of Nonsteroidal 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