{"id":"naphazoline-hydrocloride-pheniramine-maleate-panthenol","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dry mouth"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1653","moleculeType":"Small molecule","molecularWeight":"356.42"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Naphazoline hydrochloride works by stimulating the alpha-adrenergic receptors in the nasal mucosa, leading to vasoconstriction and reduction of nasal congestion. Pheniramine maleate, on the other hand, blocks the action of histamine at the H1 receptor, which is responsible for the symptoms of allergic rhinitis. Panthenol helps to soothe and moisturize the nasal mucosa, providing additional relief from nasal congestion and discomfort.","oneSentence":"Naphazoline hydrochloride is a sympathomimetic agent that acts as an alpha-adrenergic agonist, while pheniramine maleate is an antihistamine that exerts its effects by competitively inhibiting the action of histamine at the H1 receptor. Panthenol, a form of vitamin B5, has moisturizing and soothing properties.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:34.524Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Redness and congestion of the eyes due to allergic rhinitis or other conditions"}]},"trialDetails":[{"nctId":"NCT01533220","phase":"PHASE3","title":"Efficacy of Nasal Naphazoline Hydrocloride + Pheniramine Maleate + Panthenol Compared With Naphazoline Hydrocloride in the Symptomatic Control of Nasal Congestion and Nasopharyngeal","status":"COMPLETED","sponsor":"EMS","startDate":"2013-01-01","conditions":"Flu, Cold, Allergic Disorder of Respiratory System","enrollment":132}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Naphazoline hydrocloride + Pheniramine Maleate + Panthenol","genericName":"Naphazoline hydrocloride + Pheniramine Maleate + Panthenol","companyName":"EMS","companyId":"ems","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Naphazoline hydrochloride is a sympathomimetic agent that acts as an alpha-adrenergic agonist, while pheniramine maleate is an antihistamine that exerts its effects by competitively inhibiting the action of histamine at the H1 receptor. Panthenol, a form of vitamin B5, has moisturizing and soothing properties. Used for Redness and congestion of the eyes due to allergic rhinitis or other conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}