{"id":"naphazoline-hydrocloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or stinging"},{"rate":null,"effect":"Rebound congestion (with prolonged nasal use)"},{"rate":null,"effect":"Mydriasis (pupil dilation)"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1706","moleculeType":"Small molecule","molecularWeight":"246.74"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"By stimulating alpha-1 adrenergic receptors on vascular smooth muscle, naphazoline induces rapid constriction of small blood vessels. This reduces blood flow to the affected tissue, decreasing congestion, redness, and swelling. The drug is commonly used as a topical decongestant in ophthalmic and nasal formulations.","oneSentence":"Naphazoline hydrochloride is an alpha-1 adrenergic agonist that causes vasoconstriction of blood vessels in the eye or nasal passages.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:22:35.196Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ocular redness and congestion associated with minor eye irritation"},{"name":"Nasal congestion due to allergies or colds"}]},"trialDetails":[{"nctId":"NCT01533220","phase":"PHASE3","title":"Efficacy of Nasal Naphazoline Hydrocloride + Pheniramine Maleate + Panthenol Compared With Naphazoline Hydrocloride in the Symptomatic Control of Nasal Congestion and Nasopharyngeal","status":"COMPLETED","sponsor":"EMS","startDate":"2013-01-01","conditions":"Flu, Cold, Allergic Disorder of Respiratory System","enrollment":132}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"naphazoline hydrocloride","genericName":"naphazoline hydrocloride","companyName":"EMS","companyId":"ems","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Naphazoline hydrochloride is an alpha-1 adrenergic agonist that causes vasoconstriction of blood vessels in the eye or nasal passages. Used for Ocular redness and congestion associated with minor eye irritation, Nasal congestion due to allergies or colds.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}