{"id":"nano-hydroxyapatite-varnish","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth staining or discoloration"},{"rate":null,"effect":"Temporary sensitivity"},{"rate":null,"effect":"Mild gingival irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nano-hydroxyapatite is a nanocrystalline form of the primary mineral component of tooth enamel. When applied as a varnish, it penetrates micro-defects and lesions in enamel, filling gaps and promoting remineralization. This process restores enamel integrity, reduces sensitivity, and increases resistance to acid erosion and caries.","oneSentence":"Nano-hydroxyapatite varnish remineralizes and strengthens tooth enamel by depositing biocompatible calcium phosphate crystals on the tooth surface.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:56:42.817Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dental caries prevention"},{"name":"Enamel remineralization"},{"name":"Dentin hypersensitivity"},{"name":"Enamel erosion"}]},"trialDetails":[{"nctId":"NCT07229105","phase":"NA","title":"Comparative Effectiveness of Remineralization Agents on Attachment-Associated Demineralization in Clear Aligner Patients","status":"COMPLETED","sponsor":"Bezmialem Vakif University","startDate":"2024-08-12","conditions":"White Spot Lesions, Demineralization, Dental Caries","enrollment":40},{"nctId":"NCT06837779","phase":"NA","title":"Exposed Hypersensitive Dentin Treated With Fluoride Iontophoresis With Remineralizing Agents","status":"ENROLLING_BY_INVITATION","sponsor":"Al-Azhar University","startDate":"2024-07-01","conditions":"Dentin Hypersensitivity","enrollment":20},{"nctId":"NCT04887389","phase":"PHASE4","title":"Cariostatic and Remineralizing Effects of Three Different Dental Varnishes","status":"COMPLETED","sponsor":"Nisreen Ibrahim khan","startDate":"2021-08-01","conditions":"Dental Caries in Children, Cariostatic Agent, Resistance, Dental Caries","enrollment":115}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["(n-HAP)"],"phase":"marketed","status":"active","brandName":"nano-hydroxyapatite varnish","genericName":"nano-hydroxyapatite varnish","companyName":"Nisreen Ibrahim khan","companyId":"nisreen-ibrahim-khan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nano-hydroxyapatite varnish is a small molecule intervention used in dental treatments, specifically studied for its cariostatic and remineralizing effects. It has been investigated as a potential treatment for dental caries, white spot lesions, and resistance in children, among other conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}