{"id":"nandrolone-phenpropionate","rwe":[{"pmid":"18821287","year":"2008","title":"Anabolic-androgenic steroid effects on early morbid symptoms after open prostatectomy: a pilot study.","finding":"","journal":"The aging male : the official journal of the International Society for the Study of the Aging Male","studyType":"Clinical Study"},{"pmid":"8474243","year":"1993","title":"Anabolic steroid abuse and tooth size-arch dimensions in the rat.","finding":"","journal":"The Journal of the Tennessee Dental Association","studyType":"Clinical Study"},{"pmid":"8297054","year":"1993","title":"Anabolic steroids and craniofacial growth in the rat.","finding":"","journal":"The Angle orthodontist","studyType":"Clinical Study"},{"pmid":"20736","year":"1977","title":"Evidence of decarboxylation of lysine by mammalian ornithine decarboxylase.","finding":"","journal":"Acta physiologica Scandinavica","studyType":"Clinical Study"},{"pmid":"868816","year":"1977","title":"Androgens, estrogens, and the ultimate height in XO gonadal dysgenesis.","finding":"","journal":"American journal of diseases of children (1960)","studyType":"Clinical Study"}],"tags":[{"label":"Androgen","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Androgen receptor","category":"target"},{"label":"AR","category":"gene"},{"label":"ESR1","category":"gene"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Mature","category":"status"},{"label":"Organon Usa Inc","category":"company"},{"label":"Approved 1950s","category":"decade"},{"label":"Anabolic Agents","category":"pharmacology"},{"label":"Androgens","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"Merck & Co.","patents":[],"pricing":[],"allNames":"nandrolon phenylpropionate","offLabel":[],"synonyms":["nandrolone phenpropionate","nandrolon phenylpropionate","nandrolone phenylpropionate","norandrolone phenylpropionate","norandrostenolone phenylpropionate","nortestosterone phenylpropionate"],"timeline":[{"date":"1959-10-30","type":"positive","source":"DrugCentral","milestone":"FDA approval (Organon Usa Inc)"},{"date":"1983-06-17","type":"neutral","source":"FDA Orange Book","milestone":"Generic entry — 1 manufacturer approved"}],"aiSummary":"Nandrolone Phenylpropionate (NANDROLONE PHENPROPIONATE) is a small molecule androgen developed by ORGANON USA INC in 1959. It targets the androgen receptor and is used to treat various conditions. As an off-patent medication, it is available as a generic product. The commercial status of Nandrolone Phenylpropionate is off-patent, with one generic manufacturer. Key safety considerations include its potential for androgenic side effects.","approvals":[{"date":"1959-10-30","orphan":false,"company":"ORGANON USA INC","regulator":"FDA"}],"brandName":"Nandrolon Phenylpropionate","ecosystem":[],"mechanism":{"target":"Androgen receptor, Estrogen receptor","novelty":"Follow-on","targets":[{"gene":"AR","source":"DrugCentral","target":"Androgen receptor","protein":"Androgen receptor"},{"gene":"ESR1","source":"DrugCentral","target":"Estrogen receptor","protein":"Estrogen receptor"}],"modality":"Small Molecule","drugClass":"Androgen","explanation":"Imagine your body has locks on the cells that control muscle growth and bone density. Nandrolone Phenylpropionate has a key that fits into these locks, allowing it to turn on the signals that promote muscle growth and bone density. This helps to treat conditions where these signals are low.","oneSentence":"Nandrolone Phenylpropionate works by binding to androgen receptors in the body, mimicking the effects of male hormones.","technicalDetail":"Nandrolone Phenylpropionate is a non-aromatizable anabolic steroid that exerts its effects by binding to the androgen receptor (AR), a nuclear receptor that regulates gene expression in response to androgens."},"commercial":{"launchDate":"1959","_launchSource":"DrugCentral (FDA 1959-10-30, ORGANON USA INC)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1882","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=NANDROLONE%20PHENPROPIONATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=NANDROLONE 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